P07210.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
34.6 kDa
NCBI Official Full Name
Genome polyprotein
UniProt Protein Name
Genome polyprotein
UniProt Synonym Protein Names
P3Protein 3ABP2P1Capsid protein VP0Alternative name(s):VP4-VP2
UniProt Synonym Gene Names
UniProt Entry Name
POLG_HRV8A
UniProt Comments for VP1
Capsid protein VP1: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host cell receptor to provide virion attachment to target host cells. This attachment induces virion internalization. Tyrosine kinases are probably involved in the entry process. After binding to its receptor, the capsid undergoes conformational changes. Capsid protein VP1 N-terminus (that contains an amphipathic alpha-helix) and capsid protein VP4 are externalized. Together, they shape a pore in the host membrane through which viral genome is translocated to host cell cytoplasm. After genome has been released, the channel shrinks ().
Product References and Citations for VP1 recombinant protein
Evolutionary relationships within the human rhinovirus genus comparison of serotypes 89, 2, and 14.Duechler M., Skern T., Sommergruber W., Neubauer C., Gruendler P., Fogy I., Blaas D., Kuechler E.Proc. Natl. Acad. Sci. U.S.A. 84:2605-2609(1987)
Productive entry pathways of human rhinoviruses.Fuchs R., Blaas D.Adv. Virol. 2012:826301-826301(2012)
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