NP_666329.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
106,909 Da
NCBI Official Full Name
alanine--tRNA ligase, cytoplasmic
NCBI Official Synonym Full Names
alanyl-tRNA synthetase
NCBI Protein Information
alanine--tRNA ligase, cytoplasmic
UniProt Protein Name
Alanine--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names
Alanyl-tRNA synthetase
UniProt Synonym Gene Names
UniProt Comments for AARS
AARS: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Defects in AARS are the cause of Charcot-Marie-Tooth disease type 2N (CMT2N). It is an axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies(designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. Belongs to the class-II aminoacyl-tRNA synthetase family.
Protein type: EC 6.1.1.7; Ligase; RNA-binding; Translation
Chromosomal Location of Human Ortholog: 8|8 E1
Cellular Component: cytoplasm; cytosol; membrane
Molecular Function: alanine-tRNA ligase activity; amino acid binding; ATP binding; protein binding; tRNA binding
Biological Process: alanyl-tRNA aminoacylation; cerebellar Purkinje cell layer development; hair follicle development; negative regulation of neuron apoptosis; neuromuscular process; neuromuscular process controlling balance; protein folding; response to amino acid stimulus; skin development; tRNA modification; unfolded protein response
Research Articles on AARS
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Pathways associated with AARS recombinant protein
Diseases associated with AARS recombinant protein
Organs/Tissues associated with AARS recombinant protein
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