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AATF recombinant protein

Scan QR to view Datasheet Catalog #    MBS717108
SDS-Page
Unit / Price
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AATF, Recombinant Protein

 Also Known As   

Recombinant Human Protein AATF

 Product Synonym Names    Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1
 Product Gene Name   

AATF recombinant protein

[Similar Products]
 Matching Pairs    Antibody: AATF (MBS7041862)
Standard: AATF (MBS717108)
Comments: Standards are recommendations only. Compatibility of the standards in the user developed application needs to be established and confirmed by the researcher.
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    6-294
 Sequence    PLALQLEQLL NPRPSEADPE ADPEEATAAR VIDRFDEGED GEGDFLVVGS IRKLASASLL DTDKRYCGKT TSRKAWNEDH WEQTLPGSSD EEISDEEGSG DEDSEGLGLE EYDEDDLGAA EEQECGDHRE SKKSRSHSAK TPGFSVQSIS DFEKFTKGMD DLGSSEEEED EESGMEEGDD AEDSQGESEE DRAGDRNSED DGVVMTFSSV KVSEEVEKGR AVKNQIALWD QLLEGRIKLQ KALLTTNQLP QPDVF
 OMIM    608463
 3D Structure    ModBase 3D Structure for Q9NY61
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of AATF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for AATF recombinant protein

   May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacent of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dentia), although the molecular basis for this phenomenon has not been described to date.
 Product Categories/Family for AATF recombinant protein    Epigenetics and Nuclear Signaling
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 SDS-Page of AATF recombinant protein    AATF recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for AATF. It may not necessarily be applicable to this product.
 NCBI GI #    7657013
 NCBI GeneID    26574
 NCBI Accession #    NP_036270.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012138.3 [Other Products]
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 UniProt Primary Accession #    Q9NY61 [Other Products]
 UniProt Secondary Accession #    Q9P0A4; Q9UNX5; A6NCJ6; B3KQ26 [Other Products]
 UniProt Related Accession #    Q9NY61 [Other Products]
 Molecular Weight    59.1kD
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 NCBI Official Full Name    protein AATF
 NCBI Official Synonym Full Names    apoptosis antagonizing transcription factor
 NCBI Official Symbol    AATF [Similar Products]
 NCBI Official Synonym Symbols   
DED; BFR2; CHE1; CHE-1
[Similar Products]
 NCBI Protein Information    protein AATF
 UniProt Protein Name    Protein AATF
 UniProt Synonym Protein Names   
Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1
 Protein Family    Protein
 UniProt Gene Name    AATF [Similar Products]
 UniProt Synonym Gene Names    CHE1; DED [Similar Products]
 UniProt Entry Name    AATF_HUMAN
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 NCBI Summary for AATF    The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AATF    AATF: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Belongs to the AATF family.

Protein type: Nucleolus; RNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: centrosome; cytoplasm; focal adhesion; Golgi apparatus; nucleolus; nucleus

Molecular Function: leucine zipper domain binding; protein binding; tau protein binding; transcription factor activity

Biological Process: cell adhesion; embryonic cleavage; negative regulation of amyloid precursor protein biosynthetic process; negative regulation of apoptosis; negative regulation of superoxide release; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of transcription from RNA polymerase II promoter; regulation of mitotic cell cycle; response to DNA damage stimulus; ribosome biogenesis and assembly
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Product References and Citations for AATF recombinant protein

   Identification of novel transcription factor-like gene from human intestinal cells.Lindfors K., Halttunen T., Huotari P., Nupponen N., Vihinen M., Visakorpi T., Maki M., Kainulainen H.Biochem. Biophys. Res. Commun. 276:660-666(2000) Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb.Fanciulli M., Bruno T., Di Padova M., De Angelis R., Iezzi S., Iacobini C., Floridi A., Passananti C.FASEB J. 14:904-912(2000) Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.Nature 440:1045-1049(2006)
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 Research Articles on AATF    1. In the face of high glucose threat, mitochondrial UCP2 gene expression is regulated by miR-2909 and AATF.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with AATF recombinant proteinDiseases associated with AATF recombinant protein
 Products by Pathway  Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 NRAGE Signals Death Through JNK Pathway antibodies  NRAGE Signals Death Through JNK Pathway Diagram
 Regulation Of Retinoblastoma Protein Pathway antibodies  Regulation Of Retinoblastoma Protein Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
 P75 NTR Receptor-mediated Signalling Pathway antibodies  P75 NTR Receptor-mediated Signalling Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >2 publications with AATF and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >2 publications with AATF and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >2 publications with AATF and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with AATF and Cell Transformation, Neoplastic
 Inflammation Antibodies  >2 publications with AATF and Inflammation
 Acute Kidney Injury Antibodies  >1 publications with AATF and Acute Kidney Injury
 Liver Neoplasms Antibodies  >1 publications with AATF and Liver Neoplasms
 Diabetes Mellitus Antibodies  >1 publications with AATF and Diabetes Mellitus
 Liver Diseases Antibodies  >1 publications with AATF and Liver Diseases
 Necrosis Antibodies  >1 publications with AATF and Necrosis
Organs/Tissues associated with AATF recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with AATF and Brain
 Liver Antibodies  >7 publications with AATF and Liver
 Blood Antibodies  >6 publications with AATF and Blood
 Prostate Antibodies  >5 publications with AATF and Prostate
 Heart Antibodies  >4 publications with AATF and Heart
 Muscle Antibodies  >4 publications with AATF and Muscle
 Kidney Antibodies  >4 publications with AATF and Kidney
 Embryonic Tissue Antibodies  >2 publications with AATF and Embryonic Tissue
 Lung Antibodies  >2 publications with AATF and Lung
 Bone Antibodies  >2 publications with AATF and Bone
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