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ACBP recombinant protein

Scan QR to view Datasheet Catalog #    MBS203475
SDS-PAGE
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
0.5 mg  /  $640 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACBP, Recombinant Protein

★Popular Item★
 Also Known As   

ACBP, 1-87aa, Human, His tag, E Coli

 Product Synonym Names    ACBD1; CCK-RP; EP; DBI; Acyl-CoA-binding protein; Diazepam Binding Inhibitor Protein
 Product Gene Name   

ACBP recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MSQAEFEKAA EEVRHLKTKP SDEEMLFIYG HYKQATVGDI NTERPGMLDF TGKAKWDAWN ELKGTSKEDA MKAYINKVEE LKKKYGI
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.1M NaCl, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of ACBP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ACBP recombinant protein

   ACBP, also known as ACBD1, is a diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. Expression of ACBP is significantly induced during adipocyte differentiation. ACBP is a target for proliferator-activated receptor (PPAR)gamma, and is directly activated by PPARgamma/RXRalpha and PPARalpha/RXRalpha, but not by PPARdelta/RXRalpha. Recombinant human ACBP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for ACBP recombinant protein    Neuroscience
 Applications Tested/Suitable for ACBP recombinant protein   

SDS-PAGE

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 SDS-PAGE of ACBP recombinant protein    ACBP recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for ACBP. It may not necessarily be applicable to this product.
 NCBI GI #    120433590
 NCBI GeneID    1622
 NCBI Accession #    NP_001073331 [Other Products]
 NCBI GenBank Nucleotide #    NM_001079862.2 [Other Products]
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 UniProt Secondary Accession #    P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8; B8ZWD2; B8ZWD6; B8ZWD7 [Other Products]
 UniProt Related Accession #    P07108 [Other Products]
 Molecular Weight    12.2 kDa (107aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    acyl-CoA-binding protein isoform 3
 NCBI Official Synonym Full Names    diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
 NCBI Official Symbol    DBI [Similar Products]
 NCBI Official Synonym Symbols   
EP; ACBP; ACBD1; CCK-RP
[Similar Products]
 NCBI Protein Information    acyl-CoA-binding protein; GABA receptor modulator; acyl coenzyme A binding protein; acyl-Coenzyme A binding domain containing 1; cholecystokinin-releasing peptide, trypsin-sensitive; diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein); diazepam-binding inhibitor; endozepine
 UniProt Protein Name    Acyl-CoA-binding protein
 UniProt Synonym Protein Names   
Diazepam-binding inhibitor; DBI; Endozepine; EP
 UniProt Gene Name    DBI [Similar Products]
 UniProt Synonym Gene Names    ACBP; DBI; EP [Similar Products]
 UniProt Entry Name    ACBP_HUMAN
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 NCBI Summary for ACBP    This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACBP    DBI: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. Belongs to the ACBP family. 6 isoforms of the human protein are produced by alternative promoter.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 2q12-q21

Cellular Component: Golgi apparatus; mitochondrion; endoplasmic reticulum

Molecular Function: protein dimerization activity; benzodiazepine receptor binding; lipid binding

Biological Process: protein palmitoylation; triacylglycerol metabolic process; learning and/or memory; behavioral fear response; hair follicle development; transport; lateral ventricle development
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Product References and Citations for ACBP recombinant protein

   Folli F., et al. (2010) PLoS One. 5(3):e9923.
Manjithaya R., et al. (2010) J Cell Biol. 188(4):537-46.
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 Research Articles on ACBP    1. results indicate that a dysfunction of the neurosteroid system might be operative in BPD in spite of unchanged DBI plasma levels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACBP recombinant proteinPathways associated with ACBP recombinant protein
 Reference Product  PubMed Publications
 TSPO recombinant protein  >7 publications with ACBP and TSPO
 CCK recombinant protein  >5 publications with ACBP and CCK
 STAR recombinant protein  >2 publications with ACBP and STAR
 PPARG recombinant protein  >2 publications with ACBP and PPARG
 Products by Pathway  Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 SREBP Signalling Pathway antibodies  SREBP Signalling Pathway Diagram
Diseases associated with ACBP recombinant proteinOrgans/Tissues associated with ACBP recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >78 publications with ACBP and Nervous System Diseases
 Disease Models, Animal Antibodies  >30 publications with ACBP and Disease Models, Animal
 Hemorrhage Antibodies  >15 publications with ACBP and Hemorrhage
 Liver Diseases Antibodies  >14 publications with ACBP and Liver Diseases
 Necrosis Antibodies  >8 publications with ACBP and Necrosis
 Neoplasms, Experimental Antibodies  >8 publications with ACBP and Neoplasms, Experimental
 Hepatic Encephalopathy Antibodies  >7 publications with ACBP and Hepatic Encephalopathy
 Edema Antibodies  >7 publications with ACBP and Edema
 Kidney Diseases Antibodies  >7 publications with ACBP and Kidney Diseases
 Carcinoma Antibodies  >7 publications with ACBP and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >205 publications with ACBP and Brain
 Blood Antibodies  >98 publications with ACBP and Blood
 Nerve Antibodies  >35 publications with ACBP and Nerve
 Liver Antibodies  >34 publications with ACBP and Liver
 Vascular Antibodies  >31 publications with ACBP and Vascular
 Adrenal Gland Antibodies  >23 publications with ACBP and Adrenal Gland
 Kidney Antibodies  >19 publications with ACBP and Kidney
 Testis Antibodies  >18 publications with ACBP and Testis
 Heart Antibodies  >15 publications with ACBP and Heart
 Muscle Antibodies  >15 publications with ACBP and Muscle
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