NP_005772.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
119,349 Da
NCBI Official Full Name
activated CDC42 kinase 1 isoform 1
NCBI Official Synonym Full Names
tyrosine kinase non receptor 2
NCBI Protein Information
activated CDC42 kinase 1
UniProt Protein Name
Activated CDC42 kinase 1
UniProt Synonym Protein Names
Tyrosine kinase non-receptor protein 2
UniProt Synonym Gene Names
NCBI Summary for ACK1 / TNK2
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for ACK1 / TNK2
Ack: a tyrosine kinase that binds Cdc42 in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. May be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Amplification in primary tumors correlates with metastatic potential . Two differentially spliced isoforms have been described.
Protein type: Ack family; EC 2.7.10.2; EC 2.7.11.1; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: clathrin-coated vesicle; coated pit; cytoplasm; endosome; extrinsic to internal side of plasma membrane; membrane; nucleus; plasma membrane
Molecular Function: epidermal growth factor receptor binding; GTPase inhibitor activity; identical protein binding; protein binding; protein serine/threonine/tyrosine kinase activity; protein-tyrosine kinase activity; ubiquitin protein ligase binding; WW domain binding
Biological Process: cell differentiation; cell migration; cell surface receptor linked signal transduction; innate immune response; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of cell proliferation; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on ACK1 / TNK2
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Products associated with ACK1 / TNK2 recombinant protein
Pathways associated with ACK1 / TNK2 recombinant protein
Diseases associated with ACK1 / TNK2 recombinant protein
Organs/Tissues associated with ACK1 / TNK2 recombinant protein
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