NP_001123476
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31.4kDa (274aa) confirmed by MALDI-TOF
NCBI Official Full Name
alpha-actinin-1 isoform a
NCBI Official Synonym Full Names
actinin alpha 1
NCBI Official Synonym Symbols
NCBI Protein Information
alpha-actinin-1
UniProt Protein Name
Alpha-actinin-1
UniProt Synonym Protein Names
Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1
NCBI Summary for ACTN1
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACTN1
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Product References and Citations for ACTN1 recombinant protein
Hamill KJ., et al. (2014) Journal of Invest Dermatology. 135 (4):1043-52; Kunishima S., et al. (2013) Am J Hum Genet. 92 (3):431-8
Research Articles on ACTN1
Precautions
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Products associated with ACTN1 recombinant protein
Pathways associated with ACTN1 recombinant protein
Diseases associated with ACTN1 recombinant protein
Organs/Tissues associated with ACTN1 recombinant protein
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