NP_031423.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,853 Da
NCBI Official Full Name
activin receptor type-2B
NCBI Official Synonym Full Names
activin receptor IIB
NCBI Protein Information
activin receptor type-2B
UniProt Protein Name
Activin receptor type-2B
UniProt Synonym Protein Names
Activin receptor type IIB; ACTR-IIB
UniProt Synonym Gene Names
UniProt Comments for ACVR2B
ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor.
Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type2 subfamily
Chromosomal Location of Human Ortholog: 9|9 F3
Cellular Component: cytoplasm; protein complex; receptor complex
Molecular Function: activin binding; growth factor binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; transforming growth factor beta binding
Biological Process: activation of protein kinase activity; activin receptor signaling pathway; anterior/posterior pattern formation; blood vessel remodeling; BMP signaling pathway; determination of left/right symmetry; embryonic foregut morphogenesis; gastrulation with mouth forming second; heart development; insulin secretion; kidney development; lung development; lymphangiogenesis; mesoderm development; negative regulation of transcription from RNA polymerase II promoter; odontogenesis of dentine-containing teeth; organ growth; palate development; pancreas development; pattern specification process; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; post-embryonic development; regulation of signal transduction; regulation of transcription, DNA-dependent; response to glucose stimulus; signal transduction; skeletal development; skeletal morphogenesis
Research Articles on ACVR2B
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with ACVR2B recombinant protein
Diseases associated with ACVR2B recombinant protein
Organs/Tissues associated with ACVR2B recombinant protein
|