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| Product Name
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ADH1C, Recombinant Protein
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| Also Known As
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ADH1C, 1-375aa, Human, His tag, E Coli
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| Product Synonym Names
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alcohol dehydrogenase 1C; ADH3
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Sequence
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MGSSHHHHHH SSGLVPRGSH MGSHMSTAGK VIKCKAAVLW ELKKPFSIEE VEVAPPKAHE VRIKMVAAGI CRSDEHVVSG NLVTPLPVIL GHEAAGIVES VGEGVTTVKP GDKVIPLFTP QCGKCRICKN PESNYCLKND LGNPRGTLQD GTRRFTCSGK PIHHFVGVST FSQYTVVDEN AVAKIDAASP LEKVCLIGCG FSTGYGSAVK VAKVTPGSTC AVFGLGGVGL SVVMGCKAAG AARIIAVDIN KDKFAKAKEL GATECINPQD YKKPIQEVLK EMTDGGVDFS FEVIGRLDTM MASLLCCHEA CGTSVIVGVP PDSQNLSINP MLLLTGRTWK GAIFGGFKSK ESVPKLVADF MAKKFSLDAL ITNILPFEKI NEGFDLLRSG KSIRTVLTF
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| OMIM
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X04299 mRNA
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| 3D Structure
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ModBase 3D Structure for P00326
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| Host
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E Coli
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| Purity/Purification
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> 90% by SDS-PAGE
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| Form/Format
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Liquid. In 20 mM Tris-HCl Buffer, pH8.0, 10% glycerol, 2mM DTT, 200mM NaCl
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| Concentration
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0.5 mg/ml (determined by Bradford assay) (lot specific)
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| Antigen Species
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Human
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| Tag Information
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His-tag
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| Preparation and Storage
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Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
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| Other Notes
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Small volumes of ADH1C recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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Alcohol dehydrogenase 1C, also known as ADH1C, belongs to the zinc-containing alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. ADH1 is a monomorphic and predominant in fetal and infant livers, becoming less active in gestation and only weakly active during adulthood. Recombinant human ADH1C protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
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| Product Categories/Family for ADH1C recombinant protein
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Redox Proteins
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| Applications Tested/Suitable for ADH1C recombinant protein
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SDS-PAGE
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| SDS-Page of ADH1C recombinant protein
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TOP
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| NCBI/Uniprot data below describe general gene information for ADH1C. It may not necessarily be applicable to this product. |
| NCBI GI #
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4501933
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| NCBI GeneID
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126
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| NCBI Accession #
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NP_000660
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_000669.4
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[Other Products]
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| UniProt Primary Accession #
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P00326
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[Other Products]
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| UniProt Secondary Accession #
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Q4PJ18; Q5WRV0; Q6LBW4; Q6NWV0; Q6NZA7
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[Other Products]
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| UniProt Related Accession #
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P00326
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[Other Products]
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| Molecular Weight
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42.4kDa (399aa) confirmed by MALDI-TOF
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TOP
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| NCBI Official Full Name
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alcohol dehydrogenase 1C
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| NCBI Official Synonym Full Names
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alcohol dehydrogenase 1C (class I), gamma polypeptide
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| NCBI Official Symbol
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ADH1C
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[Similar Products]
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| NCBI Official Synonym Symbols
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ADH3
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[Similar Products]
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| NCBI Protein Information
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alcohol dehydrogenase 1C
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| UniProt Protein Name
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Alcohol dehydrogenase 1C
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| UniProt Synonym Protein Names
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Alcohol dehydrogenase subunit gamma
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| Protein Family
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Alcohol dehydrogenase
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| UniProt Gene Name
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ADH1C
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[Similar Products]
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| UniProt Synonym Gene Names
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ADH3
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[Similar Products]
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| NCBI Summary for ADH1C
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This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]
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| UniProt Comments for ADH1C
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MiscellaneousThere are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.
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TOP
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Jelski W., et al. (2007) Dig Dis Sci. 52:1513-1516.; Smith M., et al. (1973) Ann Hum Genet. 36:401-414.
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| Research Articles on ADH1C
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1. In analysis using the ADH1B and ADH1C genotypes as instrumental variables for alcohol consumption, the hazards ratio for atrial fibrillation per genetic drink per day was 0.79 (0.44-1.41) among men and 0.64 (0.12-3.42) among women
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Pathways associated with ADH1C recombinant protein | Diseases associated with ADH1C recombinant protein |
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| Organs/Tissues associated with ADH1C recombinant protein |
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TOP
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Recombinant Protein 
