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ADH1C recombinant protein

Scan QR to view Datasheet Catalog #    MBS204332
SDS-PAGE
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADH1C, Recombinant Protein

 Also Known As   

ADH1C, 1-375aa, Human, His tag, E Coli

 Product Synonym Names    alcohol dehydrogenase 1C; ADH3
 Product Gene Name   

ADH1C recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSHMSTAGK VIKCKAAVLW ELKKPFSIEE VEVAPPKAHE VRIKMVAAGI CRSDEHVVSG NLVTPLPVIL GHEAAGIVES VGEGVTTVKP GDKVIPLFTP QCGKCRICKN PESNYCLKND LGNPRGTLQD GTRRFTCSGK PIHHFVGVST FSQYTVVDEN AVAKIDAASP LEKVCLIGCG FSTGYGSAVK VAKVTPGSTC AVFGLGGVGL SVVMGCKAAG AARIIAVDIN KDKFAKAKEL GATECINPQD YKKPIQEVLK EMTDGGVDFS FEVIGRLDTM MASLLCCHEA CGTSVIVGVP PDSQNLSINP MLLLTGRTWK GAIFGGFKSK ESVPKLVADF MAKKFSLDAL ITNILPFEKI NEGFDLLRSG KSIRTVLTF
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl buffer, pH8.0, 10% glycerol, 2mM DTT, 200mM NaCl
 Concentration    0.5mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of ADH1C recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ADH1C recombinant protein

   Alcohol dehydrogenase 1C, also known as ADH1C, belongs to the zinc-containing alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. ADH1 is a monomorphic and predominant in fetal and infant livers, becoming less active in gestation and only weakly active during adulthood. Recombinant human ADH1C protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for ADH1C recombinant protein    Redox Proteins
 Applications Tested/Suitable for ADH1C recombinant protein   

SDS-PAGE

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 SDS-PAGE of ADH1C recombinant protein    ADH1C recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for ADH1C. It may not necessarily be applicable to this product.
 NCBI GI #    4501933
 NCBI GeneID    126
 NCBI Accession #    NP_000660 [Other Products]
 NCBI GenBank Nucleotide #    NM_000669.4 [Other Products]
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 UniProt Secondary Accession #    Q4PJ18; Q5WRV0; Q6LBW4; Q6NWV0; Q6NZA7 [Other Products]
 UniProt Related Accession #    P00326 [Other Products]
 Molecular Weight    42.4kDa (399aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    alcohol dehydrogenase 1C
 NCBI Official Synonym Full Names    alcohol dehydrogenase 1C (class I), gamma polypeptide
 NCBI Official Symbol    ADH1C [Similar Products]
 NCBI Official Synonym Symbols   
ADH3
[Similar Products]
 NCBI Protein Information    alcohol dehydrogenase 1C; ADH, gamma subunit; alcohol dehydrogenase 3 (class I), gamma polypeptide; aldehyde reductase
 UniProt Protein Name    Alcohol dehydrogenase 1C
 UniProt Synonym Protein Names   
Alcohol dehydrogenase subunit gamma
 Protein Family    Alcohol dehydrogenase
 UniProt Gene Name    ADH1C [Similar Products]
 UniProt Synonym Gene Names    ADH3 [Similar Products]
 UniProt Entry Name    ADH1G_HUMAN
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 NCBI Summary for ADH1C    This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADH1C    ADH1C: class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]

Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lipid Metabolism - fatty acid; Cofactor and Vitamin Metabolism - retinol; Amino Acid Metabolism - tyrosine; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.1.1.1; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 4q23

Cellular Component: cytosol

Molecular Function: zinc ion binding; alcohol dehydrogenase activity

Biological Process: xenobiotic metabolic process; ethanol oxidation

Disease: Alcohol Dependence; Parkinson Disease, Late-onset
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Product References and Citations for ADH1C recombinant protein

   Jelski W., et al. (2007) Dig Dis Sci. 52:1513-1516.
Smith M., et al. (1973) Ann Hum Genet. 36:401-414.
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 Research Articles on ADH1C    1. ADH1B-ADH1C-ADH7 cluster SNPs confer susceptibility to esophageal squamous cell carcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ADH1C recombinant proteinPathways associated with ADH1C recombinant protein
 Reference Product  PubMed Publications
 ALDH2 recombinant protein  >69 publications with ADH1C and ALDH2
 CYP2E1 recombinant protein  >23 publications with ADH1C and CYP2E1
 ALDH1A1 recombinant protein  >11 publications with ADH1C and ALDH1A1
 GSTM1 recombinant protein  >6 publications with ADH1C and GSTM1
 GSTP1 recombinant protein  >5 publications with ADH1C and GSTP1
 ALDH3A1 recombinant protein  >5 publications with ADH1C and ALDH3A1
 COMT recombinant protein  >4 publications with ADH1C and COMT
 GSTA2 recombinant protein  >1 publications with ADH1C and GSTA2
 CYP26A1 recombinant protein  >1 publications with ADH1C and CYP26A1
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway antibodies  Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway Diagram
 Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway antibodies  Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway Diagram
 Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway antibodies  Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway Diagram
 Defective CYP17A1 Causes Adrenal Hyperplasia 5 (AH5) Pathway antibodies  Defective CYP17A1 Causes Adrenal Hyperplasia 5 (AH5) Pathway Diagram
 Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway antibodies  Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway Diagram
 Defective CYP1B1 Causes Glaucoma Pathway antibodies  Defective CYP1B1 Causes Glaucoma Pathway Diagram
 Defective CYP21A2 Causes Adrenal Hyperplasia 3 (AH3) Pathway antibodies  Defective CYP21A2 Causes Adrenal Hyperplasia 3 (AH3) Pathway Diagram
Diseases associated with ADH1C recombinant proteinOrgans/Tissues associated with ADH1C recombinant protein
 Disease Name  Pubmed Publications
 Alcoholism Antibodies  >74 publications with ADH1C and Alcoholism
 Genetic Predisposition to Disease Antibodies  >51 publications with ADH1C and Genetic Predisposition to Disease
 Liver Diseases Antibodies  >22 publications with ADH1C and Liver Diseases
 Cardiovascular Diseases Antibodies  >18 publications with ADH1C and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >12 publications with ADH1C and Breast Neoplasms
 Nervous System Diseases Antibodies  >8 publications with ADH1C and Nervous System Diseases
 Pancreatitis Antibodies  >8 publications with ADH1C and Pancreatitis
 Mouth Neoplasms Antibodies  >8 publications with ADH1C and Mouth Neoplasms
 Brain Diseases Antibodies  >7 publications with ADH1C and Brain Diseases
 Atherosclerosis Antibodies  >6 publications with ADH1C and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >43 publications with ADH1C and Liver
 Heart Antibodies  >14 publications with ADH1C and Heart
 Stomach Antibodies  >13 publications with ADH1C and Stomach
 Brain Antibodies  >9 publications with ADH1C and Brain
 Lung Antibodies  >8 publications with ADH1C and Lung
 Intestine Antibodies  >6 publications with ADH1C and Intestine
 Pharynx Antibodies  >4 publications with ADH1C and Pharynx
 Bone Antibodies  >1 publications with ADH1C and Bone
 Muscle Antibodies  >1 publications with ADH1C and Muscle
 Bladder Antibodies  >1 publications with ADH1C and Bladder
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