NP_079128.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,211 Da
NCBI Official Full Name
protein argonaute-3 isoform a
NCBI Official Synonym Full Names
argonaute 3, RISC catalytic component
NCBI Official Synonym Symbols
NCBI Protein Information
protein argonaute-3
UniProt Protein Name
Protein argonaute-3
UniProt Synonym Protein Names
Argonaute RISC catalytic component 3; Eukaryotic translation initiation factor 2C 3
UniProt Synonym Gene Names
NCBI Summary for AGO3
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for AGO3
AGO3: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Belongs to the argonaute family. Ago subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 1p34.3
Cellular Component: cytoplasm; cytosol; membrane
Molecular Function: double-stranded RNA binding; miRNA binding; protein binding; single-stranded RNA binding
Biological Process: miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, mRNA cleavage; miRNA-mediated gene silencing, negative regulation of translation; miRNA-mediated gene silencing, production of miRNAs; mRNA catabolic process; phosphoinositide-mediated signaling; pre-microRNA processing; RNA secondary structure unwinding; RNA-mediated posttranscriptional gene silencing; Wnt receptor signaling pathway, calcium modulating pathway
Research Articles on AGO3
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Pathways associated with AGO3 recombinant protein
Diseases associated with AGO3 recombinant protein
Organs/Tissues associated with AGO3 recombinant protein
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