Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow AHSP  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Sulfatide (SFT) ELISA Kit
 • Gram Negative Endotoxin (E. coli 0:111 B4 J5) Antibody
 • A disintegrin and metalloproteinase with thrombospondin moti... Recombinant Protein
 • Heparin-Platelet Factor 4 Antibodies (HPF4) ELISA Kit
 • High Density Lipoprotein 2 (HDL2) ELISA Kit
 • Dihydrotestosterone, DHT ELISA Kit
 • 1,25-Dihydroxyvitamin D3 (1,25 DHVD3) ELISA Kit
 • translocase of outer mitochondrial membrane 20 homolog Antibody
 • DEFB4A Antibody
 • L-lactate dehydrogenase A chain (PIG19) Recombinant Protein
 • Gliadin Antibody
 • Collagen Type VI, Human (COL6A1) Native Protein
 • Osteopontin (OPN) ELISA Kit
 • PYGL Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

AHSP recombinant protein

Scan QR to view Datasheet Catalog #    MBS203370
SDS-PAGE
Unit / Price
0.1 mg  /  $255 +1 FREE 8GB USB
0.5 mg  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AHSP, Recombinant Protein

 Also Known As   

AHSP, 1-102aa, Human, Recombinant, E Coli

 Product Synonym Names    ERAF; EDRF; Alpha-hemoglobin stabilizing protein Alpha hemoglobin stabilizing protein; Erythroid associated factor; Erythroid differentiation associated factor; Erythroid differentiation related factor
 Product Gene Name   

AHSP recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN YYRQQVTGEP QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP SS
Section Bar
Section Bar
 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
Section Bar
 Antigen Species    Human
 Expression System    E Coli
 Endotoxin    < 1.0 Eu per 1 microgram of protein (determined by LAL method)
Section Bar
 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of AHSP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for AHSP recombinant protein

   AHSP(Alpha-hemoglobin stabilizing protein), also known as ERAF(Erythroid associated factor), is an erythroid-specific protein that acts as a chaperone to prevent the aggregation of alpha-hemoglobin during normal erythroid cell development. It specifically protects free alpha-hemoglobin from precipitation in live cells and in solution. This protein is downregulated in transmissible spongiform encephalopathies (TSEs). It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. Recombinant AHSP protein was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for AHSP recombinant protein    Heat Shock Proteins
 Applications Tested/Suitable for AHSP recombinant protein   

SDS-PAGE

Section Bar
 SDS-PAGE of AHSP recombinant protein    AHSP recombinant protein SDS-PAGE image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for AHSP. It may not necessarily be applicable to this product.
 NCBI GI #    7706180
 NCBI GeneID    51327
 NCBI Accession #    NP_057717 [Other Products]
 NCBI GenBank Nucleotide #    NM_016633.2 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q8TD01 [Other Products]
 UniProt Related Accession #    Q9NZD4 [Other Products]
 Molecular Weight    11.8 kDa (102aa), confirmed by MALDI-TOF.
Table BarTOPTable Bar
 NCBI Official Full Name    alpha-hemoglobin-stabilizing protein
 NCBI Official Synonym Full Names    alpha hemoglobin stabilizing protein
 NCBI Official Symbol    AHSP [Similar Products]
 NCBI Official Synonym Symbols   
EDRF; ERAF
[Similar Products]
 NCBI Protein Information    alpha-hemoglobin-stabilizing protein; alpha hemoglobin stabilising protein; erythroid associated factor; erythroid differentiation associated factor; erythroid differentiation-related factor; erythroid-associated factor
 UniProt Protein Name    Alpha-hemoglobin-stabilizing protein
 UniProt Synonym Protein Names   
Erythroid differentiation-related factor; Erythroid-associated factor
 Protein Family    Alpha-hemoglobin-stabilizing protein
 UniProt Gene Name    AHSP [Similar Products]
 UniProt Synonym Gene Names    EDRF; ERAF [Similar Products]
 UniProt Entry Name    AHSP_HUMAN
Section Bar
 UniProt Comments for AHSP    AHSP: Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. Belongs to the AHSP family.

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: hemoglobin complex

Molecular Function: hemoglobin binding; unfolded protein binding

Biological Process: protein stabilization; protein folding; hemoglobin metabolic process; hemopoiesis
Table BarTOPTable Bar
 

Product References and Citations for AHSP recombinant protein

   Dos Santos CO., et al. (2008) J Biol Chem. 283(40):26956-64.
Sekijima Y., et al. (2005) Cell. 121(1):73-85.
Section Bar
 Research Articles on AHSP    1. The relationship between AHSP gene expression, disease severity, and the beta/alpha globin mRNA ratio was studied among different homozygote beta-thalassemia patients.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with AHSP recombinant proteinDiseases associated with AHSP recombinant protein
 Reference Product  PubMed Publications
 GATA1 recombinant protein  >7 publications with AHSP and GATA1
 NGB recombinant protein  >1 publications with AHSP and NGB
 KLF1 recombinant protein  >1 publications with AHSP and KLF1
 Disease Name  Pubmed Publications
 Anemia Antibodies  >39 publications with AHSP and Anemia
 Anemia, Hemolytic Antibodies  >35 publications with AHSP and Anemia, Hemolytic
 Vascular Diseases Antibodies  >3 publications with AHSP and Vascular Diseases
 Fetal Growth Retardation Antibodies  >1 publications with AHSP and Fetal Growth Retardation
 Inflammation Antibodies  >1 publications with AHSP and Inflammation
 Abnormalities, Multiple Antibodies  >1 publications with AHSP and Abnormalities, Multiple
 Atherosclerosis Antibodies  >1 publications with AHSP and Atherosclerosis
 Hypertension Antibodies  >1 publications with AHSP and Hypertension
 Splenomegaly Antibodies  >1 publications with AHSP and Splenomegaly
 Pneumonia Antibodies  >1 publications with AHSP and Pneumonia
Organs/Tissues associated with AHSP recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >73 publications with AHSP and Blood
 Bone Marrow Antibodies  >7 publications with AHSP and Bone Marrow
 Liver Antibodies  >4 publications with AHSP and Liver
 Heart Antibodies  >2 publications with AHSP and Heart
 Spleen Antibodies  >2 publications with AHSP and Spleen
 Lung Antibodies  >1 publications with AHSP and Lung
 Embryonic Tissue Antibodies  >1 publications with AHSP and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions