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AHSP recombinant protein

Scan QR to view Datasheet Catalog #    MBS203370
SDS-Page
Unit / Price
0.1 mg  /  $255 +1 FREE 8GB USB
0.5 mg  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AHSP, Recombinant Protein

 Also Known As   

AHSP, 1-102aa, Human, E Coli

 Product Synonym Names    Alpha-hemoglobin stabilizing protein; ERAF; EDRF; Alpha-hemoglobin stabilizing protein Alpha hemoglobin stabilizing protein; Erythroid associated factor; Erythroid differentiation associated factor; Erythroid differentiation related factor
 Product Gene Name   

AHSP recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN YYRQQVTGEP QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP SS
 OMIM    AF364517 mRNA
 3D Structure    ModBase 3D Structure for Q9NZD4
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Endotoxin Level    < 1.0 EU per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of AHSP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AHSP recombinant protein

   AHSP (Alpha-hemoglobin stabilizing protein), also known as ERAF (Erythroid associated factor), is an erythroid-specific protein that acts as a chaperone to prevent the aggregation of alpha-hemoglobin during normal erythroid cell development. It specifically protects free alpha-hemoglobin from precipitation in live cells and in solution. This protein is downregulated in transmissible spongiform encephalopathies (TSEs). It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. Recombinant AHSP protein was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for AHSP recombinant protein    Heat Shock Proteins
 Applications Tested/Suitable for AHSP recombinant protein   

SDS-PAGE

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 SDS-Page of AHSP recombinant protein    AHSP recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for AHSP. It may not necessarily be applicable to this product.
 NCBI GI #    7706180
 NCBI GeneID    51327
 NCBI Accession #    NP_057717 [Other Products]
 NCBI GenBank Nucleotide #    NM_016633.3 [Other Products]
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 UniProt Primary Accession #    Q9NZD4 [Other Products]
 UniProt Secondary Accession #    Q8TD01 [Other Products]
 UniProt Related Accession #    Q9NZD4 [Other Products]
 Molecular Weight    11.8 kDa (102aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    alpha-hemoglobin-stabilizing protein
 NCBI Official Synonym Full Names    alpha hemoglobin stabilizing protein
 NCBI Official Symbol    AHSP [Similar Products]
 NCBI Official Synonym Symbols   
EDRF; ERAF
[Similar Products]
 NCBI Protein Information    alpha-hemoglobin-stabilizing protein
 UniProt Protein Name    Alpha-hemoglobin-stabilizing protein
 UniProt Synonym Protein Names   
Erythroid differentiation-related factor; Erythroid-associated factor
 Protein Family    Alpha-hemoglobin-stabilizing protein
 UniProt Gene Name    AHSP [Similar Products]
 UniProt Synonym Gene Names    EDRF; ERAF [Similar Products]
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 NCBI Summary for AHSP    This gene encodes a molecular chaperone which binds specifically to free alpha-globin and is involved in hemoglobin assembly. The encoded protein binds to monomeric alpha-globin until it has been transferred to beta-globin to form a heterodimer, which in turn binds to another heterodimer to form the stable tetrameric hemoglobin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
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 UniProt Comments for AHSP    Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.
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Product References and Citations for AHSP recombinant protein

   Dos Santos CO., et al. (2008) J Biol Chem. 283 (40):26956-64. ; Sekijima Y., et al. (2005) Cell. 121 (1):73-85.;
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 Research Articles on AHSP    1. In the presence of free alpha subunits and H2O2, both HbA and HbE showed bCys93 oxidation which increased with higher H2O2 concentrations. In the presence of Alpha-hemoglobin stabilizing protein (AHSP)Cys93 oxidation was substantially reduced in both proteins.in the presence of excess free alpha-subunit and under the same oxidative conditions, these events are substantially increased for HbE compared to HbA
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AHSP recombinant proteinDiseases associated with AHSP recombinant protein
 Reference Product  PubMed Publications
 EPB42 recombinant protein  >1 publications with AHSP and EPB42
 HBA1 recombinant protein  >1 publications with AHSP and HBA1
 HBA2 recombinant protein  >1 publications with AHSP and HBA2
 Disease Name  Pubmed Publications
 Anemia Antibodies  >47 publications with AHSP and Anemia
 Cardiovascular Diseases Antibodies  >8 publications with AHSP and Cardiovascular Diseases
 Vascular Diseases Antibodies  >6 publications with AHSP and Vascular Diseases
 Heart Diseases Antibodies  >4 publications with AHSP and Heart Diseases
 Immune System Diseases Antibodies  >3 publications with AHSP and Immune System Diseases
 Edema Antibodies  >2 publications with AHSP and Edema
 Cognition Disorders Antibodies  >2 publications with AHSP and Cognition Disorders
 Inflammation Antibodies  >2 publications with AHSP and Inflammation
 Hypertension Antibodies  >1 publications with AHSP and Hypertension
 Fetal Death Antibodies  >1 publications with AHSP and Fetal Death
Organs/Tissues associated with AHSP recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >89 publications with AHSP and Blood
 Heart Antibodies  >9 publications with AHSP and Heart
 Bone Marrow Antibodies  >8 publications with AHSP and Bone Marrow
 Liver Antibodies  >4 publications with AHSP and Liver
 Lung Antibodies  >2 publications with AHSP and Lung
 Embryonic Tissue Antibodies  >2 publications with AHSP and Embryonic Tissue
 Spleen Antibodies  >2 publications with AHSP and Spleen
 Skin Antibodies  >1 publications with AHSP and Skin
 Eye Antibodies  >1 publications with AHSP and Eye
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