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AIFM1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS205698
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AIFM1, Recombinant Protein

★Popular Item★
 Also Known As   

AIFM1, 98-609aa, Human, His tag, E Coli

 Product Synonym Names    Apoptosis-inducing factor 1 mitochondrial isoform 2 precursor; Apoptosis-inducing factor 1; mitochondrial isoform 2 precursor; AIF; CMTX4; COWCK; COXPD6; PDCD8
 Product Gene Name   

AIFM1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSEFLGLTP EQKQKKAALS ASEGEEVPQD KAPSHVPFLL IGGGTAAFAA ARSIRARDPG ARVLIVSEDP ELPYMRPPLS KELWFSDDPN VTKTLRFKQW NGKERSIYFQ PPSFYVSAQD LPHIENGGVA VLTGKKVVQL DVRDNMVKLN DGSQITYEKC LIATGGTPRS LSAIDRAGAE VKSRTTLFRK IGDFRSLEKI SREVKSITII GGGFLGSELA CALGRKARAL GTEVIQLFPE KGNMGKILPE YLSNWTMEKV RREGVKVMPN AIVQSVGVSS GKLLIKLKDG RKVETDHIVA AVGLEPNVEL AKTGGLEIDS DFGGFRVNAE LQARSNIWVA GDAACFYDIK LGRRRVEHHD HAVVSGRLAG ENMTGAAKPY WHQSMFWSDL GPDVGYEAIG LVDSSLPTVG VFAKATAQDN PKSATEQSGT GIRSESETES EASEITIPPS TPAVPQAPVQ GEDYGKGVIF YLRDKVVVGI VLWNIFNRMP IARKIIKDGE QHEDLNEVAK LFNIHED
 OMIM    AF100928 mRNA
 3D Structure    ModBase 3D Structure for O95831
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of AIFM1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AIFM1 recombinant protein

   Apoptosis-inducing factor 1, mitochondrial isoform 2 precursor, also known as AIFM1, is a mitochondrial protein that translocates to the nucleus upon induction of apoptosis. AIFM1 has been shown to cause DNA fragmentation and chromatin condensation and to induce the release of cytochrome c and caspase-9 from mitochondria. Bcl-2 overexpression has been shown to prevent the release of AIFM1 from mitochondria, but not to block its apoptogenic activity. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Recombinant human AIFM1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for AIFM1 recombinant protein    Metabolism
 Applications Tested/Suitable for AIFM1 recombinant protein   

SDS-PAGE

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 SDS-Page of AIFM1 recombinant protein    AIFM1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for AIFM1. It may not necessarily be applicable to this product.
 NCBI GI #    22202629
 NCBI GeneID    9131
 NCBI Accession #    NP_665811 [Other Products]
 NCBI GenBank Nucleotide #    NM_145812.2 [Other Products]
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 UniProt Primary Accession #    O95831 [Other Products]
 UniProt Secondary Accession #    Q1L6K4; Q1L6K6; Q2QKE4; Q5JUZ7; Q6I9X6; Q9Y3I3; Q9Y3I4; A4QPB4; B1ALN1; B2RB08; D3DTE9 [Other Products]
 UniProt Related Accession #    O95831 [Other Products]
 Molecular Weight    58.5 kDa (537aa)
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 NCBI Official Full Name    apoptosis-inducing factor 1, mitochondrial isoform AIF-exB
 NCBI Official Synonym Full Names    apoptosis inducing factor mitochondria associated 1
 NCBI Official Symbol    AIFM1 [Similar Products]
 NCBI Official Synonym Symbols   
AIF; CMT2D; CMTX4; COWCK; DFNX5; NADMR; NAMSD; PDCD8; COXPD6
[Similar Products]
 NCBI Protein Information    apoptosis-inducing factor 1, mitochondrial
 UniProt Protein Name    Apoptosis-inducing factor 1, mitochondrial
 UniProt Synonym Protein Names   
Programmed cell death protein 8
 UniProt Gene Name    AIFM1 [Similar Products]
 UniProt Synonym Gene Names    AIF; PDCD8 [Similar Products]
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 NCBI Summary for AIFM1    This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015]
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 UniProt Comments for AIFM1    Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
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Product References and Citations for AIFM1 recombinant protein

   Zamzami N., et al. (1996) J Exp Med. 183: 1533-1544.; Susin S A., et al. (1996) J Exp Med. 184: 1331-1341.;
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 Research Articles on AIFM1    1. Data revealed that under a nutrient deficient condition, CD317 functions as an anti-apoptotic factor through AIF-mediated caspase and autophagy-independent manner.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AIFM1 recombinant proteinPathways associated with AIFM1 recombinant protein
 Reference Product  PubMed Publications
 BAX recombinant protein  >82 publications with AIFM1 and BAX
 PARP1 recombinant protein  >19 publications with AIFM1 and PARP1
 BCL2L1 recombinant protein  >16 publications with AIFM1 and BCL2L1
 BCL2 recombinant protein  >14 publications with AIFM1 and BCL2
 BAD recombinant protein  >8 publications with AIFM1 and BAD
 ENDOG recombinant protein  >7 publications with AIFM1 and ENDOG
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 Nanomaterial Induced Apoptosis Pathway antibodies  Nanomaterial Induced Apoptosis Pathway Diagram
Diseases associated with AIFM1 recombinant proteinOrgans/Tissues associated with AIFM1 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >50 publications with AIFM1 and Nervous System Diseases
 Necrosis Antibodies  >43 publications with AIFM1 and Necrosis
 Brain Diseases Antibodies  >41 publications with AIFM1 and Brain Diseases
 Breast Neoplasms Antibodies  >21 publications with AIFM1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >16 publications with AIFM1 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >12 publications with AIFM1 and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >5 publications with AIFM1 and Heart Diseases
 Neoplasms, Experimental Antibodies  >5 publications with AIFM1 and Neoplasms, Experimental
 Inflammation Antibodies  >4 publications with AIFM1 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >4 publications with AIFM1 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >48 publications with AIFM1 and Brain
 Blood Antibodies  >39 publications with AIFM1 and Blood
 Lung Antibodies  >23 publications with AIFM1 and Lung
 Muscle Antibodies  >19 publications with AIFM1 and Muscle
 Liver Antibodies  >18 publications with AIFM1 and Liver
 Skin Antibodies  >11 publications with AIFM1 and Skin
 Heart Antibodies  >10 publications with AIFM1 and Heart
 Vascular Antibodies  >10 publications with AIFM1 and Vascular
 Kidney Antibodies  >9 publications with AIFM1 and Kidney
 Prostate Antibodies  >8 publications with AIFM1 and Prostate
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