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AIMP1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203997
SDS-Page
Unit / Price
0.01 mg  /  $310 +1 FREE 8GB USB
0.05 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AIMP1, Recombinant Protein

 Also Known As   

AIMP1, 1-336aa, Human, His tag, E Coli

 Product Synonym Names    Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; EMAP2; EMAPII; p43; SCYE1
 Product Gene Name   

AIMP1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MLPAVAVSEP VVLRFMIFCR LLAKMANNDA VLKRLEQKGA EADQIIEYLK QQVSLLKEKA ILQATLREEK KLRVENAKLK KEIEELKQEL IQAEIQNGVK QIPFPSGTPL HANSMVSENV IQSTAVTTVS SGTKEQIKGG TGDEKKAKEK IEKKGEKKEK KQQSIAGSAD SKPIDVSRLD LRIGCIITAR KHPDADSLYV EEVDVGEIAP RTVVSGLVNH VPLEQMQNRM VILLCNLKPA KMRGVLSQAM VMCASSPEKI EILAPPNGSV PGDRITFDAF PGEPDKELNP KKKIWEQIQP DLHTNDECVA TYKGVPFEVK GKGVCRAQTM SNSGIK
 OMIM    U10117 mRNA
 3D Structure    ModBase 3D Structure for Q12904
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 Host    E Coli
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 Purity/Purification    > 85% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 0.2M NaCl, 2mM DTT, 10% glycerol
 Concentration    0.25 mg/ml (determined by BCA assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of AIMP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AIMP1 recombinant protein

   AIMP1, also known as EMPA2 or p43, is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Recombinant human AIMP1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for AIMP1 recombinant protein    Cancer
 Applications Tested/Suitable for AIMP1 recombinant protein   

SDS-PAGE

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 SDS-Page of AIMP1 recombinant protein    AIMP1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for AIMP1. It may not necessarily be applicable to this product.
 NCBI GI #    215490011
 NCBI GeneID    9255
 NCBI Accession #    NP_001135888 [Other Products]
 NCBI GenBank Nucleotide #    NM_001142416.1 [Other Products]
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 UniProt Primary Accession #    Q12904 [Other Products]
 UniProt Secondary Accession #    Q6FG28; Q96CQ9; B3KTR2; B4E1S7 [Other Products]
 UniProt Related Accession #    Q12904 [Other Products]
 Molecular Weight    39.2 kDa (356aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
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 NCBI Official Full Name    aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform b
 NCBI Official Synonym Full Names    aminoacyl tRNA synthetase complex interacting multifunctional protein 1
 NCBI Official Symbol    AIMP1 [Similar Products]
 NCBI Official Synonym Symbols   
p43; HLD3; EMAP2; SCYE1; EMAPII
[Similar Products]
 NCBI Protein Information    aminoacyl tRNA synthase complex-interacting multifunctional protein 1
 UniProt Protein Name    Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
 UniProt Synonym Protein Names   
Multisynthase complex auxiliary component p43
 Protein Family    Aminoacyl tRNA synthase complex-interacting multifunctional protein
 UniProt Gene Name    AIMP1 [Similar Products]
 UniProt Synonym Gene Names    EMAP2; SCYE1; EMAP-2; EMAP-II [Similar Products]
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 NCBI Summary for AIMP1    The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
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 UniProt Comments for AIMP1    Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
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Product References and Citations for AIMP1 recombinant protein

   Zhu X., et al. (2009) Proc Natl Acad Sci u S A. 106 (37):15944-9.; Kim E., et al. (2008) J Immunol. 180 (5):2894-902.;
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 Research Articles on AIMP1    1. This study showed the potential of the anti-AIMP1 antibody as a therapeutic option for AD treatment. Also, the finding of an association of blood AIMP1 levels with the MMSE score.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AIMP1 recombinant proteinPathways associated with AIMP1 recombinant protein
 Reference Product  PubMed Publications
 AIMP2 recombinant protein  >10 publications with AIMP1 and AIMP2
 EPRS recombinant protein  >3 publications with AIMP1 and EPRS
 KARS recombinant protein  >2 publications with AIMP1 and KARS
 LARS recombinant protein  >2 publications with AIMP1 and LARS
 RARS recombinant protein  >2 publications with AIMP1 and RARS
 MARS recombinant protein  >2 publications with AIMP1 and MARS
 DARS recombinant protein  >1 publications with AIMP1 and DARS
 IARS recombinant protein  >1 publications with AIMP1 and IARS
 QARS recombinant protein  >1 publications with AIMP1 and QARS
 Products by Pathway  Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 SeMet Incorporation Into Proteins Pathway antibodies  SeMet Incorporation Into Proteins Pathway Diagram
 Selenoamino Acid Metabolism Pathway antibodies  Selenoamino Acid Metabolism Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram
Diseases associated with AIMP1 recombinant proteinOrgans/Tissues associated with AIMP1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >10 publications with AIMP1 and Inflammation
 Fibrosis Antibodies  >3 publications with AIMP1 and Fibrosis
 Necrosis Antibodies  >3 publications with AIMP1 and Necrosis
 Lung Neoplasms Antibodies  >2 publications with AIMP1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >2 publications with AIMP1 and Breast Neoplasms
 Liver Diseases Antibodies  >2 publications with AIMP1 and Liver Diseases
 Neurobehavioral Manifestations Antibodies  >2 publications with AIMP1 and Neurobehavioral Manifestations
 LEUKODYSTROPHY, HYPOMYELINATING, 3 Antibodies  >2 publications with AIMP1 and LEUKODYSTROPHY, HYPOMYELINATING, 3
 Nervous System Malformations Antibodies  >1 publications with AIMP1 and Nervous System Malformations
 Congenital Abnormalities Antibodies  >1 publications with AIMP1 and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with AIMP1 and Blood
 Lung Antibodies  >6 publications with AIMP1 and Lung
 Bone Antibodies  >5 publications with AIMP1 and Bone
 Brain Antibodies  >5 publications with AIMP1 and Brain
 Stomach Antibodies  >3 publications with AIMP1 and Stomach
 Vascular Antibodies  >3 publications with AIMP1 and Vascular
 Muscle Antibodies  >2 publications with AIMP1 and Muscle
 Liver Antibodies  >2 publications with AIMP1 and Liver
 Intestine Antibodies  >2 publications with AIMP1 and Intestine
 Spleen Antibodies  >2 publications with AIMP1 and Spleen
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