NP_004186.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,110 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 18 isoform 1
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily member 18
NCBI Protein Information
tumor necrosis factor receptor superfamily member 18
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 18
UniProt Synonym Protein Names
Activation-inducible TNFR family receptor; Glucocorticoid-induced TNFR-related protein; CD_antigen: CD357
UniProt Synonym Gene Names
UniProt Entry Name
TNR18_HUMAN
UniProt Comments for AITR
TNFRSF18: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Receptor, cytokine
Chromosomal Location of Human Ortholog: 1p36.3
Cellular Component: integral to plasma membrane; plasma membrane
Biological Process: immune response; induction of apoptosis via death domain receptors; inflammatory response; multicellular organismal development; positive regulation of cell adhesion; positive regulation of leukocyte migration; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of cell proliferation; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway
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Products associated with AITR recombinant protein
Pathways associated with AITR recombinant protein
Diseases associated with AITR recombinant protein
Organs/Tissues associated with AITR recombinant protein
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