NP_001344.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38.9 kDa
NCBI Official Full Name
aldo-keto reductase family 1 member C1
NCBI Official Synonym Full Names
aldo-keto reductase family 1, member C1
NCBI Official Synonym Symbols
C9; DD1; DDH; DDH1; H-37; HBAB; MBAB; HAKRC; DD1/DD2; 2-ALPHA-HSD; 20-ALPHA-HSD [Similar Products]
NCBI Protein Information
aldo-keto reductase family 1 member C1
UniProt Protein Name
Aldo-keto reductase family 1 member C1
UniProt Synonym Protein Names
20-alpha-hydroxysteroid dehydrogenase (EC:1.1.1.149); 20-alpha-HSD; Chlordecone reductase homolog HAKRC; Dihydrodiol dehydrogenase 1/2; DD1/DD2; High-affinity hepatic bile acid-binding protein; HBAB; Indanol dehydrogenase (EC:1.1.1.112); Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC:1.3.1.20)
UniProt Synonym Gene Names
UniProt Entry Name
AK1C1_HUMAN
NCBI Summary for AKR1C1
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
UniProt Comments for AKR1C1
AKR1C1: Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. Belongs to the aldo/keto reductase family.
Protein type: EC 1.1.1.112; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.1.1.149; EC 1.3.1.20; Oxidoreductase
Chromosomal Location of Human Ortholog: 10p15-p14
Cellular Component: cytosol
Molecular Function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; ketosteroid monooxygenase activity; 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity; carboxylic acid binding; bile acid binding; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; aldo-keto reductase activity; 20-alpha-hydroxysteroid dehydrogenase activity; indanol dehydrogenase activity; aldehyde reductase activity; phenanthrene 9,10-monooxygenase activity
Biological Process: bile acid and bile salt transport; phototransduction, visible light; cholesterol homeostasis; response to organophosphorus; retinal metabolic process; epithelial cell differentiation; bile acid metabolic process; xenobiotic metabolic process; digestion; cholesterol absorption; progesterone metabolic process; retinoid metabolic process; protein homooligomerization
Research Articles on AKR1C1
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Products associated with AKR1C1 active protein
Diseases associated with AKR1C1 active protein
Organs/Tissues associated with AKR1C1 active protein
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