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Alk recombinant protein :: ALK tyrosine kinase receptor (Alk), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS953744 Alk recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,175 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,175 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,405 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,405 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,835 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,835 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,295 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,295 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,330 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $3,620 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALK tyrosine kinase receptor (Alk), partial, Recombinant Protein

 Also Known As   

Recombinant Mouse ALK tyrosine kinase receptor (Alk), partial

 Product Synonym Names    ALK tyrosine kinase receptor; EC=2.7.10.1; Anaplastic lymphoma kinase; CD_antigen=; CD246
 Product Gene Name   

Alk recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    268-640, Fragment at the extracellular domain, include the MAM1 domain, LDL-receptor class A domain and MAM2 domain
 Sequence    LECSFDFPCE LEYSPPLHNH GNQSWSWRHV PSEEASRMNL LDGPEAEHSQ EMPRGSFLLL NTSADSKHTI LSPWMRSSSD HCTLAVSVHR HLQPSGRYVA QLLPHNEAGR EILLVPTPGK HGWTVLQGRV GRPANPFRVA LEYISSGNRS LSAVDFFALK NCSEGTSPGS KMALQSSFTC WNGTVLQLGQ ACDFHQDCAQ GEDEGQLCSK LPAGFYCNFE NGFCGWTQSP LSPHMPRWQV RTLRDAHSQG HQGRALLLST TDILASEGAT VTSATFPAPM KNSPCELRMS WLIRGVLRGN VSLVLVENKT GKEQSRTVWH VATDEGLSLW QHTVLSLLDV TDRFWLQIVT WWGPGSRATV GFDNISISLD CYL
 3D Structure    ModBase 3D Structure for P97793
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Alk recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Alk. It may not necessarily be applicable to this product.
 NCBI GI #    110347475
 NCBI GeneID    11682
 NCBI Accession #    NP_031465.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007439.2 [Other Products]
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 UniProt Primary Accession #    P97793 [Other Products]
 UniProt Secondary Accession #    E9QKV3 [Other Products]
 UniProt Related Accession #    P97793 [Other Products]
 Molecular Weight    174,948 Da
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 NCBI Official Full Name    ALK tyrosine kinase receptor
 NCBI Official Synonym Full Names    anaplastic lymphoma kinase
 NCBI Official Symbol    Alk [Similar Products]
 NCBI Official Synonym Symbols   
Tcrz; CD246
[Similar Products]
 NCBI Protein Information    ALK tyrosine kinase receptor
 UniProt Protein Name    ALK tyrosine kinase receptor
 UniProt Synonym Protein Names   
Anaplastic lymphoma kinase; CD_antigen: CD246
 Protein Family    ALK tyrosine kinase receptor
 UniProt Gene Name    Alk [Similar Products]
 UniProt Entry Name    ALK_MOUSE
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 UniProt Comments for Alk    ALK: a tyrosine kinase of the ALK family. Plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. Translocated and expressed as a fusion protein in anaplastic lymphoma. About one third of large-cell lymphomas are caused by a t(2;5)(p23;q35) translocation that fuses ALK to nucleophosmin (NPM1A). Other cases caused by fusions of ALK to moesin, non-muscle myosin heavy chain 9, clathrin heavy chain and other genes. Several fusions also seen in inflammatory myofibroblastic tumors, and expression has been briefly noted in a range of tumors

Protein type: Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Oncoprotein; Membrane protein, integral; TK group; Alk family

Cellular Component: protein complex; membrane; integral to plasma membrane; axon; plasma membrane; integral to membrane

Molecular Function: transferase activity; protein binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; protein kinase activity

Biological Process: nervous system development; peptidyl-tyrosine phosphorylation; activation of MAPK activity; protein amino acid autophosphorylation; neuron development; signal transduction; phosphorylation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on Alk    1. Reduced ALK1 expression is associated with increased extracellular matrix protein expression, proliferation and migration in fibroblasts.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Alk recombinant proteinPathways associated with Alk recombinant protein
 Reference Product  PubMed Publications
 Eml4 recombinant protein  >445 publications with Alk and Eml4
 Stat3 recombinant protein  >91 publications with Alk and Stat3
 Smad2 recombinant protein  >85 publications with Alk and Smad2
 Ptn recombinant protein  >24 publications with Alk and Ptn
 Jak3 recombinant protein  >15 publications with Alk and Jak3
 Npm1 recombinant protein  >14 publications with Alk and Npm1
 Zc3hc1 recombinant protein  >5 publications with Alk and Zc3hc1
 Cebpb recombinant protein  >3 publications with Alk and Cebpb
 Irs1 recombinant protein  >2 publications with Alk and Irs1
 Products by Pathway  Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
Diseases associated with Alk recombinant proteinOrgans/Tissues associated with Alk recombinant protein
 Disease Name  Pubmed Publications
 Lymphoma, Large-Cell, Anaplastic Antibodies  >1011 publications with Alk and Lymphoma, Large-Cell, Anaplastic
 Lung Diseases Antibodies  >763 publications with Alk and Lung Diseases
 Carcinoma, Non-Small-Cell Lung Antibodies  >498 publications with Alk and Carcinoma, Non-Small-Cell Lung
 Lymphoma, Large B-Cell, Diffuse Antibodies  >335 publications with Alk and Lymphoma, Large B-Cell, Diffuse
 Chromosome Aberrations Antibodies  >297 publications with Alk and Chromosome Aberrations
 Neuroblastoma Antibodies  >163 publications with Alk and Neuroblastoma
 Death Antibodies  >128 publications with Alk and Death
 Neoplasms, Experimental Antibodies  >112 publications with Alk and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >108 publications with Alk and Cell Transformation, Neoplastic
 Inflammation Antibodies  >107 publications with Alk and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >217 publications with Alk and Brain
 Eye Antibodies  >76 publications with Alk and Eye
 Embryonic Tissue Antibodies  >66 publications with Alk and Embryonic Tissue
 Dorsal Root Ganglion Antibodies  >7 publications with Alk and Dorsal Root Ganglion
 Nasopharynx Antibodies  >3 publications with Alk and Nasopharynx
 Pineal Gland Antibodies  >1 publications with Alk and Pineal Gland
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