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Alk recombinant protein :: ALK tyrosine kinase receptor (Alk) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS953744 Alk recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $785 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $895 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,025 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,050 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,155 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,205 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,275 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,305 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,360 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,645 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,875 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,930 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,070 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,490 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALK tyrosine kinase receptor (Alk), Recombinant Protein

 Also Known As   

Recombinant Mouse ALK tyrosine kinase receptor (Alk) , partial

 Product Gene Name   

Alk recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    268-640, Fragment at the extracellular domain, include the MAM1 domain, LDL-receptor class A domain and MAM2 domain
 Sequence    LECSFDFPCE LEYSPPLHNH GNQSWSWRHV PSEEASRMNL LDGPEAEHSQ EMPRGSFLLL NTSADSKHTI LSPWMRSSSD HCTLAVSVHR HLQPSGRYVA QLLPHNEAGR EILLVPTPGK HGWTVLQGRV GRPANPFRVA LEYISSGNRS LSAVDFFALK NCSEGTSPGS KMALQSSFTC WNGTVLQLGQ ACDFHQDCAQ GEDEGQLCSK LPAGFYCNFE NGFCGWTQSP LSPHMPRWQV RTLRDAHSQG HQGRALLLST TDILASEGAT VTSATFPAPM KNSPCELRMS WLIRGVLRGN VSLVLVENKT GKEQSRTVWH VATDEGLSLW QHTVLSLLDV TDRFWLQIVT WWGPGSRATV GFDNISISLD CYL
 3D Structure    ModBase 3D Structure for P97793
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Alk recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Alk recombinant protein

   The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3 half of ALK, derived from chromosome 2, is fused to the 5 portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
NCBI/Uniprot data below describe general gene information for Alk. It may not necessarily be applicable to this product.
 NCBI GI #    110347475
 NCBI GeneID    11682
 NCBI Accession #    NP_031465.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007439.2 [Other Products]
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 UniProt Primary Accession #    P97793 [Other Products]
 UniProt Secondary Accession #    E9QKV3 [Other Products]
 UniProt Related Accession #    P97793 [Other Products]
 Molecular Weight    174,948 Da
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 NCBI Official Full Name    ALK tyrosine kinase receptor
 NCBI Official Synonym Full Names    anaplastic lymphoma kinase
 NCBI Official Symbol    Alk [Similar Products]
 NCBI Official Synonym Symbols   
Tcrz; CD246
[Similar Products]
 NCBI Protein Information    ALK tyrosine kinase receptor
 UniProt Protein Name    ALK tyrosine kinase receptor
 UniProt Synonym Protein Names   
Anaplastic lymphoma kinase; CD_antigen: CD246
 Protein Family    ALK tyrosine kinase receptor
 UniProt Gene Name    Alk [Similar Products]
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 UniProt Comments for Alk    Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
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 Research Articles on Alk    1. Increased ETS exposure was closely associated with EGFR mutations in female never-smokers with NSCLC in the expanded multinational cohort. However, the association of ETS and ALK rearrangements in never-smokers with NSCLC was not significant.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Alk recombinant proteinPathways associated with Alk recombinant protein
 Reference Product  PubMed Publications
 Pik3ca recombinant protein  >113 publications with Alk and Pik3ca
 Ptn recombinant protein  >25 publications with Alk and Ptn
 Acvr1b recombinant protein  >15 publications with Alk and Acvr1b
 Acvr1c recombinant protein  >8 publications with Alk and Acvr1c
 Tdgf1 recombinant protein  >5 publications with Alk and Tdgf1
 Zc3hc1 recombinant protein  >5 publications with Alk and Zc3hc1
 Tgfbr1 recombinant protein  >2 publications with Alk and Tgfbr1
 Pik3cg recombinant protein  >1 publications with Alk and Pik3cg
 Products by Pathway  Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
Diseases associated with Alk recombinant proteinOrgans/Tissues associated with Alk recombinant protein
 Disease Name  Pubmed Publications
 Respiratory Tract Diseases Antibodies  >1292 publications with Alk and Respiratory Tract Diseases
 Lung Diseases Antibodies  >1215 publications with Alk and Lung Diseases
 Lung Neoplasms Antibodies  >1204 publications with Alk and Lung Neoplasms
 Lymphoma, Large-Cell, Anaplastic Antibodies  >1195 publications with Alk and Lymphoma, Large-Cell, Anaplastic
 Carcinoma, Non-Small-Cell Lung Antibodies  >798 publications with Alk and Carcinoma, Non-Small-Cell Lung
 Chromosome Aberrations Antibodies  >357 publications with Alk and Chromosome Aberrations
 Lymphoma, Large B-Cell, Diffuse Antibodies  >355 publications with Alk and Lymphoma, Large B-Cell, Diffuse
 Neuroblastoma Antibodies  >216 publications with Alk and Neuroblastoma
 Adenocarcinoma of lung Antibodies  >142 publications with Alk and Adenocarcinoma of lung
 Inflammation Antibodies  >134 publications with Alk and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >294 publications with Alk and Brain
 Eye Antibodies  >90 publications with Alk and Eye
 Embryonic Tissue Antibodies  >67 publications with Alk and Embryonic Tissue
 Dorsal Root Ganglion Antibodies  >7 publications with Alk and Dorsal Root Ganglion
 Nasopharynx Antibodies  >3 publications with Alk and Nasopharynx
 Pineal Gland Antibodies  >1 publications with Alk and Pineal Gland
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