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Alx1 recombinant protein :: ALX homeobox protein 1 (Alx1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1470346 Alx1 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,085 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,085 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,315 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,315 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,710 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,710 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,170 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,170 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALX homeobox protein 1 (Alx1), Recombinant Protein

 Also Known As   

Recombinant Rat ALX homeobox protein 1 (Alx1)

 Product Synonym Names    ALX homeobox protein 1; Cartilage homeoprotein 1; CART-1
 Product Gene Name   

Alx1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Alx1; Cart1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-326
 Sequence    MEFLSEKFAL KSPPSKNSDF YMGTGGALEH VMETLDNESF YGKATAGKCV QAFGPLPRAE HHVRLDRTSP CQDSSVNYGI TKVEGQPLHT ELNRAMDGCN NLRMSPVKGM PEKSELDELG DKCDSNVSSS KKRRHRTTFT SLQLEELEKV FQKTHYPDVY VREQLALRTE LTEARVQVWF QNRRAKWRKR ERYGQIQQAK SHFAATYDIS VLPRTDSYPQ IQNNLWAGNT SGGSVVTSCM LPRDASSCMT PYSHSPRTDS SYTGFSNHQN QFGHVPLNNF FTDSLLTGTT NGHAFETKPE FERRSSSIAV LRMKAKEHTA NISWAM
 3D Structure    ModBase 3D Structure for Q63087
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Alx1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Alx1. It may not necessarily be applicable to this product.
 NCBI GI #    6978601
 NCBI GeneID    25401
 NCBI Accession #    NP_037053.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012921.1 [Other Products]
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 UniProt Primary Accession #    Q63087 [Other Products]
 UniProt Related Accession #    Q63087 [Other Products]
 Molecular Weight    36,904 Da
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 NCBI Official Full Name    ALX homeobox protein 1
 NCBI Official Synonym Full Names    ALX homeobox 1
 NCBI Official Symbol    Alx1 [Similar Products]
 NCBI Official Synonym Symbols   
Cart1; CART1X
[Similar Products]
 NCBI Protein Information    ALX homeobox protein 1; CART-1; cartilage homeoprotein 1; cartilage homeo protein 1
 UniProt Protein Name    ALX homeobox protein 1
 UniProt Synonym Protein Names   
Cartilage homeoprotein 1; CART-1
 Protein Family    ALX homeobox protein
 UniProt Gene Name    Alx1 [Similar Products]
 UniProt Synonym Gene Names    Cart1; CART-1 [Similar Products]
 UniProt Entry Name    ALX1_RAT
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 NCBI Summary for Alx1    homeodomain transcription factor that may play a role in chondrocyte differentiation [RGD, Feb 2006]
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 UniProt Comments for Alx1    Cart1: Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. Functions as a repressor with the prolactin promoter in vivo. May play a role in chondrocyte differentiation and may also influence cervix development. Defects in ALX1 are the cause of frontonasal dysplasia type 3 (FND3). The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline. Belongs to the paired homeobox family.

Protein type: DNA-binding

Cellular Component: nucleoplasm; Golgi apparatus; transcription factor complex; nucleus

Molecular Function: protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity

Biological Process: anterior/posterior pattern formation; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; palate development; skeletal development; embryonic limb morphogenesis; embryonic skeletal morphogenesis; mesenchymal cell development
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 Research Articles on Alx1    1. p300/CBP stimulate Cart1-dependent transcription activity, and this transactivation is inhibited by E1A and Tax, oncoproteins that suppress the activity of p300/CBP
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with Alx1 recombinant proteinOrgans/Tissues associated with Alx1 recombinant protein
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >10 publications with Alx1 and Congenital Abnormalities
 Craniofacial Abnormalities Antibodies  >8 publications with Alx1 and Craniofacial Abnormalities
 Neural Tube Defects Antibodies  >6 publications with Alx1 and Neural Tube Defects
 Nervous System Malformations Antibodies  >5 publications with Alx1 and Nervous System Malformations
 Carcinoma Antibodies  >4 publications with Alx1 and Carcinoma
 FRONTONASAL DYSPLASIA 3 Antibodies  >3 publications with Alx1 and FRONTONASAL DYSPLASIA 3
 Abnormalities, Multiple Antibodies  >2 publications with Alx1 and Abnormalities, Multiple
 Embryo Loss Antibodies  >2 publications with Alx1 and Embryo Loss
 Eye Abnormalities Antibodies  >2 publications with Alx1 and Eye Abnormalities
 Ovarian Neoplasms Antibodies  >1 publications with Alx1 and Ovarian Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >9 publications with Alx1 and Connective Tissue
 Embryonic Tissue Antibodies  >8 publications with Alx1 and Embryonic Tissue
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