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ANXA1 recombinant protein :: ANNEXIN I Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS232452 ANXA1 recombinant protein
Unit / Price
0.025 mg  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ANNEXIN I (ANXA1), Recombinant Protein

 Also Known As   

RECOMBINANT HUMAN ANNEXIN I

 Product Gene Name   

ANXA1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    151690
 3D Structure    ModBase 3D Structure for P04083
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 Form/Format    Purified recombinant protein - liquid
 Concentration    Total protein concentration 0.2mg/ml (lot specific)
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 Preparation    Purified recombinant 6xHis-tagged ANXA1 expressed in E Coli
 Buffer Solution    Phosphate buffered saline
 Target Species    Human
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 Preparation and Storage    Store at -70 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.
 Other Notes    Small volumes of ANXA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ANXA1 recombinant protein

   Annexin I (ANXA1), otherwise known as Lipocortin 1, is a calcium-dependent phospholipid-binding protein and member of the annexin family, preferentially expressed on the cytosolic face of the plasma membrane, which acts as an inhibitor of phospholipase A2, and may exhibit anti-inflammatory activity. Increased expression of the ANXA1 gene in hairy cell leukaemia, can be used in immunohistochemistry as a highly-sensitive diagnostic marker.
 Applications Tested/Suitable for ANXA1 recombinant protein   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ANXA1. It may not necessarily be applicable to this product.
 NCBI GI #    4502101
 NCBI GeneID    301
 NCBI Accession #    NP_000691.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000700.2 [Other Products]
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 UniProt Primary Accession #    P04083 [Other Products]
 UniProt Related Accession #    P04083 [Other Products]
 Molecular Weight    41.4kD (368 amino acid residues with tag) [Similar Products]
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 NCBI Official Full Name    annexin A1
 NCBI Official Synonym Full Names    annexin A1
 NCBI Official Symbol    ANXA1 [Similar Products]
 NCBI Official Synonym Symbols   
ANX1; LPC1
[Similar Products]
 NCBI Protein Information    annexin A1; annexin I (lipocortin I); annexin-1; calpactin II; calpactin-2; chromobindin-9; phospholipase A2 inhibitory protein
 UniProt Protein Name    Annexin A1
 UniProt Synonym Protein Names   
Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35
 Protein Family    Annexin
 UniProt Gene Name    ANXA1 [Similar Products]
 UniProt Synonym Gene Names    ANX1; LPC1 [Similar Products]
 UniProt Entry Name    ANXA1_HUMAN
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 NCBI Summary for ANXA1    This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
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 UniProt Comments for ANXA1    ANXA1: a calcium/phospholipid-binding protein with which promotes membrane fusion and is involved in endocytosis. Has anti-inflammatory properties and inhibits phospholipase A2 activity. Accumulates on internalized vesicles after EGF-stimulated endocytosis, suggesting that it may be required for a late stage in inward vesiculation. Phosphorylated by PKC, EGFR and Chak1. Phosphorylation results in loss of the inhibitory activity. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Calcium-binding; Lipid-binding

Chromosomal Location of Human Ortholog: 9q21.13

Cellular Component: extracellular space; cell surface; focal adhesion; protein complex; mast cell granule; basolateral plasma membrane; extracellular region; cornified envelope; cilium; cytoplasm; mitochondrial membrane; plasma membrane; nucleus; sarcolemma; vesicle; endosome

Molecular Function: protein binding, bridging; protein binding; protein homodimerization activity; single-stranded RNA binding; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; double-stranded DNA-dependent ATPase activity; phospholipid binding; calcium ion binding; structural molecule activity; calcium-dependent protein binding; helicase activity; single-stranded DNA binding; receptor binding

Biological Process: prostate gland development; response to drug; response to peptide hormone stimulus; positive regulation of neutrophil apoptosis; gliogenesis; alpha-beta T cell differentiation; positive regulation of vesicle fusion; signal transduction; arachidonic acid secretion; neutrophil homeostasis; endocrine pancreas development; DNA duplex unwinding; response to estradiol stimulus; regulation of cell proliferation; keratinocyte differentiation; cell surface receptor linked signal transduction; insulin secretion; DNA strand renaturation; peptide cross-linking; inflammatory response; cell motility; negative regulation of apoptosis; positive regulation of prostaglandin biosynthetic process; response to X-ray
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 Research Articles on ANXA1    1. AnxA1 participates in a paradigm in which malignant prostate epithelial cells that are not cancer stem cells are induced to gain cancer stem cell-like properties.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ANXA1 recombinant proteinPathways associated with ANXA1 recombinant protein
 Reference Product  PubMed Publications
 FPR2 recombinant protein  >25 publications with ANXA1 and FPR2
 FPR1 recombinant protein  >14 publications with ANXA1 and FPR1
 POMC recombinant protein  >12 publications with ANXA1 and POMC
 S100A11 recombinant protein  >5 publications with ANXA1 and S100A11
 FPR3 recombinant protein  >3 publications with ANXA1 and FPR3
 S100A6 recombinant protein  >2 publications with ANXA1 and S100A6
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway antibodies  Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with ANXA1 recombinant proteinOrgans/Tissues associated with ANXA1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >82 publications with ANXA1 and Inflammation
 Carcinoma Antibodies  >57 publications with ANXA1 and Carcinoma
 Disease Models, Animal Antibodies  >26 publications with ANXA1 and Disease Models, Animal
 Brain Diseases Antibodies  >19 publications with ANXA1 and Brain Diseases
 Neoplasm Metastasis Antibodies  >18 publications with ANXA1 and Neoplasm Metastasis
 Carcinoma, Squamous Cell Antibodies  >17 publications with ANXA1 and Carcinoma, Squamous Cell
 Lung Diseases Antibodies  >16 publications with ANXA1 and Lung Diseases
 Cardiovascular Diseases Antibodies  >12 publications with ANXA1 and Cardiovascular Diseases
 Necrosis Antibodies  >12 publications with ANXA1 and Necrosis
 Fibrosis Antibodies  >10 publications with ANXA1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >91 publications with ANXA1 and Blood
 Brain Antibodies  >29 publications with ANXA1 and Brain
 Lung Antibodies  >25 publications with ANXA1 and Lung
 Vascular Antibodies  >21 publications with ANXA1 and Vascular
 Liver Antibodies  >15 publications with ANXA1 and Liver
 Pituitary Gland Antibodies  >13 publications with ANXA1 and Pituitary Gland
 Stomach Antibodies  >11 publications with ANXA1 and Stomach
 Lymph Node Antibodies  >11 publications with ANXA1 and Lymph Node
 Bone Antibodies  >10 publications with ANXA1 and Bone
 Kidney Antibodies  >10 publications with ANXA1 and Kidney
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