NP_061039
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36.4 kDa (322aa) confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)
NCBI Official Full Name
AP-1 complex-associated regulatory protein isoform 1
NCBI Official Synonym Full Names
adaptor related protein complex 1 associated regulatory protein
NCBI Official Synonym Symbols
2C18; GBAR; C4orf16; PRO0971; gamma-BAR [Similar Products]
NCBI Protein Information
AP-1 complex-associated regulatory protein
UniProt Protein Name
AP-1 complex-associated regulatory protein
UniProt Synonym Protein Names
2c18; Adaptor-related protein complex 1-associated regulatory protein; Gamma-1-adaptin brefeldin A resistance protein; GBAR; Gamma-BAR; Gamma-A1-adaptin and kinesin interactor; Gadkin
UniProt Synonym Gene Names
UniProt Comments for AP1AR
Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.
Product References and Citations for AP1AR recombinant protein
Neubrand V.E., et al. (2005) EMBO J. 24:1122-1133; Wollscheid B., et al. (2009) Nat. Biotechnol. 27:378-386;
Research Articles on AP1AR
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