NP_011399.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
67,360 Da
NCBI Official Full Name
ubiquitin-protein transferase activating protein CDC20
NCBI Official Synonym Symbols
NCBI Protein Information
ubiquitin-protein transferase activating protein CDC20
UniProt Protein Name
APC/C activator protein CDC20
UniProt Synonym Protein Names
Cell division control protein 20
UniProt Comments for CDC20
Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). At the metaphase-to-anaphase transition, recognizes and binds proteins containing a D-box including the B-type cyclins CLB2 and CLB5, HSL1 and securin PDS1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for sister chromatid separation and disassembly of the mitotic spindle. Target of the spindle checkpoint pathway through participation in the mitotic checkpoint complex (MCC) and the MAD2-CDC20 subcomplex. MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20 until proper attachment of all chromosomes to the spindle.
Research Articles on CDC20
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Products associated with CDC20 recombinant protein
Pathways associated with CDC20 recombinant protein
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