NP_001074288.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
206,400 Da
NCBI Official Full Name
AT-rich interactive domain-containing protein 1A
NCBI Official Synonym Full Names
AT rich interactive domain 1A (SWI-like)
NCBI Official Synonym Symbols
Osa1; BAF250a; Smarcf1; 1110030E03Rik [Similar Products]
NCBI Protein Information
AT-rich interactive domain-containing protein 1A
UniProt Protein Name
AT-rich interactive domain-containing protein 1A
UniProt Synonym Protein Names
BRG1-associated factor 250; BAF250; BRG1-associated factor 250a; BAF250A; Osa homolog 1; SWI-like protein; SWI/SNF complex protein p270; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
UniProt Synonym Gene Names
Baf250; Baf250a; Osa1; Smarcf1; ARID domain-containing protein 1A; BAF250; BAF250A [Similar Products]
UniProt Comments for Arid1a
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523).
Research Articles on Arid1a
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Products associated with Arid1a recombinant protein
Pathways associated with Arid1a recombinant protein
Diseases associated with Arid1a recombinant protein
Organs/Tissues associated with Arid1a recombinant protein
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