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KCNJ1 recombinant protein :: ATP-sensitive inward rectifier potassium channel 1 (KCNJ1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS964715
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATP-sensitive inward rectifier potassium channel 1 (KCNJ1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human ATP-sensitive inward rectifier potassium channel 1 (KCNJ1)

 Product Synonym Names    Recombinant ATP-sensitive inward rectifier potassium channel 1 (KCNJ1); ATP-sensitive inward rectifier potassium channel 1; ATP-regulated potassium channel ROM-K Inward rectifier K(+) channel Kir1.1 Potassium channel, inwardly rectifying subfamily J membe
 Product Gene Name   

KCNJ1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    KCNJ1; ROMK1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    178-391aa; Cytoplasmic Domain
 Sequence    ILAKISRPKK RAKTITFSKN AVISKRGGKL CLLIRVANLR KSLLIGSHIY GKLLKTTVTP EGETIILDQI NINFVVDAGN ENLFFISPLT IYHVIDHNSP FFHMAAETLL QQDFELVVFL DGTVESTSAT CQVRTSYVPE EVLWGYRFAP IVSKTKEGKY RVDFHNFSKT VEVETPHCAM CLYNEKDVRA RMKRGYDNPN FILSEVNETD DTKM
 Chromosome Location    Chromosome: 11; NC_000011.9 (128707915..128737268, complement). Location: 11q24
 OMIM    241200
 3D Structure    ModBase 3D Structure for P48048
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of KCNJ1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for KCNJ1 purchase    Normal human kidney function requires cell membrane electrochemical potentials, maintained by pumping of inwardly rectifying potassium channels and ATP. One such potassium channel is the gated KCNJ. with gene expression in a wide range of tissues, especially kidney. The KCNJ1 gene, is a subfamily member of a large cluster of ATP sensitive rectifier - rectifying channels. Genome wide studies have implicated ATP-sensitive inward rectifier potassium channel in the pathophysiology of kidney diabetes complications. To aid in functional studies in human mouse or rat systems and cell culture, KCNJ1 recombinant protein (Kir 1) may be requested and produced from a conserved domain found by an alignment tool BLAST for potassium inwardly rectifying channel 1. Sequence, RNA and DNA, are verified for this product by free article (s) established in PubMed database resources. This and similar products are custom produced and purified according to personal specifications to allow flexible use in cells.
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Related Product Information for KCNJ1 recombinant protein

   In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
 Product Categories/Family for KCNJ1 recombinant protein    Signal Transduction
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 SDS-PAGE of KCNJ1 recombinant protein    KCNJ1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for KCNJ1. It may not necessarily be applicable to this product.
 NCBI GI #    4504837
 NCBI GeneID    3758
 NCBI Accession #    NP_000211.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000220.4 [Other Products]
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 UniProt Primary Accession #    P48048 [Other Products]
 UniProt Secondary Accession #    Q6LD67; B2RMR4 [Other Products]
 UniProt Related Accession #    P48048 [Other Products]
 Molecular Weight    25 kDa [Similar Products]
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 NCBI Official Full Name    ATP-sensitive inward rectifier potassium channel 1 isoform a
 NCBI Official Synonym Full Names    potassium inwardly-rectifying channel, subfamily J, member 1
 NCBI Official Symbol    KCNJ1 [Similar Products]
 NCBI Official Synonym Symbols   
ROMK; ROMK1; KIR1.1
[Similar Products]
 NCBI Protein Information    ATP-sensitive inward rectifier potassium channel 1; inwardly rectifying K+ channel; inward rectifier K(+) channel Kir1.1; ATP-regulated potassium channel ROM-K; potassium channel, inwardly rectifying subfamily J member 1
 UniProt Protein Name    ATP-sensitive inward rectifier potassium channel 1
 UniProt Synonym Protein Names   
ATP-regulated potassium channel ROM-K; Inward rectifier K(+) channel Kir1.1; Potassium channel, inwardly rectifying subfamily J member 1
 Protein Family    ATP-sensitive inward rectifier potassium channel
 UniProt Gene Name    KCNJ1 [Similar Products]
 UniProt Synonym Gene Names    ROMK1 [Similar Products]
 UniProt Entry Name    IRK1_HUMAN
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 NCBI Summary for KCNJ1    Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KCNJ1    ROMK: an inward rectifier-type potassium channel protein. Probably plays a major role in potassium homeostasis in the kidney. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The channel is activated by internal ATP and can be blocked by external barium. High levels of expression in the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. Three alternatively spliced isoforms have been described.

Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q24

Cellular Component: voltage-gated potassium channel complex; plasma membrane

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; ATP-activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; ATP binding

Biological Process: synaptic transmission; potassium ion import; tissue homeostasis; kidney development; excretion; potassium ion transport; post-embryonic development

Disease: Bartter Syndrome, Antenatal, Type 2
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 Research Articles on KCNJ1    1. no mutation in the KCNJ1 gene, among patients suffering from bartter and Gitelman syndromes
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KCNJ1 recombinant proteinPathways associated with KCNJ1 recombinant protein
 Reference Product  PubMed Publications
 SGK1 recombinant protein  >10 publications with KCNJ1 and SGK1
 SLC9A3R2 recombinant protein  >2 publications with KCNJ1 and SLC9A3R2
 GOLGA3 recombinant protein  >1 publications with KCNJ1 and GOLGA3
 Products by Pathway  Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Potassium Transport Channels Pathway antibodies  Potassium Transport Channels Pathway Diagram
Diseases associated with KCNJ1 recombinant proteinOrgans/Tissues associated with KCNJ1 recombinant protein
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >62 publications with KCNJ1 and Kidney Diseases
 Bartter Syndrome Antibodies  >53 publications with KCNJ1 and Bartter Syndrome
 Water-Electrolyte Imbalance Antibodies  >24 publications with KCNJ1 and Water-Electrolyte Imbalance
 Hypertension Antibodies  >23 publications with KCNJ1 and Hypertension
 Hypokalemia Antibodies  >22 publications with KCNJ1 and Hypokalemia
 Cardiovascular Diseases Antibodies  >15 publications with KCNJ1 and Cardiovascular Diseases
 Fibrosis Antibodies  >12 publications with KCNJ1 and Fibrosis
 Disease Models, Animal Antibodies  >8 publications with KCNJ1 and Disease Models, Animal
 Polyuria Antibodies  >7 publications with KCNJ1 and Polyuria
 Calcium Metabolism Disorders Antibodies  >7 publications with KCNJ1 and Calcium Metabolism Disorders
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >163 publications with KCNJ1 and Kidney
 Liver Antibodies  >5 publications with KCNJ1 and Liver
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