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Kcnj1 recombinant protein :: ATP-sensitive inward rectifier potassium channel 1 (Kcnj1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717525 Kcnj1 recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATP-sensitive inward rectifier potassium channel 1 (Kcnj1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Rat ATP-sensitive inward rectifier potassium channel 1 (Kcnj1)

 Product Synonym Names    Recombinant ATP-sensitive inward rectifier potassium channel 1 (Kcnj1); ATP-sensitive inward rectifier potassium channel 1; ATP-regulated potassium channel ROM-K Inward rectifier K(+) channel Kir1.1 KAB-1 Potassium channel, inwardly rectifying subfamily J
 Product Gene Name   

Kcnj1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Kcnj1; Romk1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-391
 Sequence    MGASERSVFR VLIRALTERM FKHLRRWFIT HIFGRSRQRA RLVSKEGRCN IEFGNVDAQS RFIFFVDIWT TVLDLKWRYK MTVFITAFLG SWFLFGLLWY VVAYVHKDLP EFYPPDNRTP CVENINGMTS AFLFSLETQV TIGYGFRFVT EQCATAIFLL IFQSILGVII NSFMCGAILA KISRPKKRAK TITFSKNAVI SKRGGKLCLL IRVANLRKSL LIGSHIYGKL LKTTITPEGE TIILDQTNIN FVVDAGNENL FFISPLTIYH IIDHNSPFFH MAAETLSQQD FELVVFLDGT VESTSATCQV RTSYVPEEVL WGYRFVPIVS KTKEGKYRVD FHNFGKTVEV ETPHCAMCLY NEKDARARMK RGYDNPNFVL SEVDETDDTQ M
 Chromosome Location    Chromosome: 8; NC_005107.3 (33453597..33454750). Location: 8q21
 3D Structure    ModBase 3D Structure for P35560
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Kcnj1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Kcnj1. It may not necessarily be applicable to this product.
 NCBI GI #    8393649
 NCBI GeneID    24521
 NCBI Accession #    NP_058719.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_017023.1 [Other Products]
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 UniProt Primary Accession #    P35560 [Other Products]
 UniProt Secondary Accession #    O88639; O88640; Q9QUR5 [Other Products]
 UniProt Related Accession #    P35560 [Other Products]
 Molecular Weight    44,963 Da [Similar Products]
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 NCBI Official Full Name    ATP-sensitive inward rectifier potassium channel 1
 NCBI Official Synonym Full Names    potassium inwardly-rectifying channel, subfamily J, member 1
 NCBI Official Symbol    Kcnj1 [Similar Products]
 NCBI Official Synonym Symbols   
Kcnj; ROMK1
[Similar Products]
 NCBI Protein Information    ATP-sensitive inward rectifier potassium channel 1; KAB-1; kir1.1; K+ channel protein; inward rectifier K(+) channel Kir1.1; ATP-regulated potassium channel ROM-K; Potassium inwardly-rectifying channel subfamily J; potassium channel, inwardly rectifying subfamily J member 1
 UniProt Protein Name    ATP-sensitive inward rectifier potassium channel 1
 UniProt Synonym Protein Names   
ATP-regulated potassium channel ROM-K; Inward rectifier K(+) channel Kir1.1; KAB-1; Potassium channel, inwardly rectifying subfamily J member 1
 Protein Family    ATP-sensitive inward rectifier potassium channel
 UniProt Gene Name    Kcnj1 [Similar Products]
 UniProt Synonym Gene Names    Romk1 [Similar Products]
 UniProt Entry Name    IRK1_RAT
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 NCBI Summary for Kcnj1    potassium channel involved in K+ secretion in the renal distal nephron [RGD, Feb 2006]
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 UniProt Comments for Kcnj1    Function: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.

Enzyme regulation: Inhibited by WNK3

By similarity.

Subunit structure: Interacts with SGK1 and SLC9A3R2/NHERF2

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein. Note: Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane

By similarity.

Tissue specificity: Mainly in kidney (renal cortex, medulla and papilla). In the brain, found in the cortex and the hippocampus.

Post-translational modification: Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane

By similarity.

Sequence similarities: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily. [View classification]
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 Research Articles on Kcnj1    1. The findings support ROMK as the pore-forming subunit of the cytoprotective mitoK(ATP) channel in heart mitochondria.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Kcnj1 recombinant proteinDiseases associated with Kcnj1 recombinant protein
 Products by Pathway  Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Potassium Transport Channels Pathway antibodies  Potassium Transport Channels Pathway Diagram
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >62 publications with Kcnj1 and Kidney Diseases
 Bartter Syndrome Antibodies  >53 publications with Kcnj1 and Bartter Syndrome
 Water-Electrolyte Imbalance Antibodies  >24 publications with Kcnj1 and Water-Electrolyte Imbalance
 Hypertension Antibodies  >23 publications with Kcnj1 and Hypertension
 Hypokalemia Antibodies  >22 publications with Kcnj1 and Hypokalemia
 Cardiovascular Diseases Antibodies  >15 publications with Kcnj1 and Cardiovascular Diseases
 Fibrosis Antibodies  >12 publications with Kcnj1 and Fibrosis
 Disease Models, Animal Antibodies  >8 publications with Kcnj1 and Disease Models, Animal
 Polyuria Antibodies  >7 publications with Kcnj1 and Polyuria
 Calcium Metabolism Disorders Antibodies  >7 publications with Kcnj1 and Calcium Metabolism Disorders
Organs/Tissues associated with Kcnj1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >163 publications with Kcnj1 and Kidney
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