NP_001166445.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
43,574 Da
NCBI Official Full Name
ATP-sensitive inward rectifier potassium channel 11
NCBI Protein Information
ATP-sensitive inward rectifier potassium channel 11
UniProt Protein Name
ATP-sensitive inward rectifier potassium channel 11
UniProt Synonym Protein Names
IKATP; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11
UniProt Comments for KCNJ11
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation ().
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Diseases associated with KCNJ11 recombinant protein
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