NP_057395.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
6,592 Da
NCBI Official Full Name
ATPase inhibitor, mitochondrial isoform 1
NCBI Official Synonym Full Names
ATPase inhibitory factor 1
NCBI Protein Information
ATPase inhibitor, mitochondrial; ATP synthase inhibitor protein; ATPase inhibitor protein; IF(1); IF1; inhibitor of F(1)F(o)-ATPase
UniProt Protein Name
ATPase inhibitor, mitochondrial
UniProt Synonym Protein Names
Inhibitor of F(1)F(o)-ATPase; IF(1); IF1
UniProt Synonym Gene Names
UniProt Entry Name
ATIF1_HUMAN
NCBI Summary for ATPIF1
This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for ATPIF1
ATPIF1: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Homodimer at a pH value below 6.5, inactive homotetramer above. Belongs to the ATPase inhibitor family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Inhibitor; Mitochondrial
Chromosomal Location of Human Ortholog: 1p35.3
Cellular Component: cell surface; mitochondrion; mitochondrial proton-transporting ATP synthase complex
Molecular Function: calmodulin binding; enzyme inhibitor activity; angiostatin binding; protein homodimerization activity; ATPase inhibitor activity; ATPase binding
Biological Process: generation of precursor metabolites and energy; regulation of gene expression; negative regulation of hydrolase activity; negative regulation of endothelial cell proliferation; erythrocyte differentiation; angiogenesis; mitochondrial depolarization; protein homooligomerization; negative regulation of nucleotide metabolic process; heme biosynthetic process; protein homotetramerization
Research Articles on ATPIF1
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Pathways associated with ATPIF1 recombinant protein
Diseases associated with ATPIF1 recombinant protein
Organs/Tissues associated with ATPIF1 recombinant protein
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