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Chrnb1 recombinant protein :: Acetylcholine receptor subunit beta (Chrnb1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS957056 Chrnb1 recombinant protein
Unit / Price
1 mg (E-Coli)  /  $1,425 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,880 +2 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Acetylcholine receptor subunit beta (Chrnb1), Recombinant Protein

 Also Known As   

Recombinant Mouse Acetylcholine receptor subunit beta (Chrnb1)

 Product Synonym Names    Recombinant Acetylcholine receptor subunit beta (Chrnb1); Acetylcholine receptor subunit beta
 Product Gene Name   

Chrnb1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Chrnb1; Acrb [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    24-244
 Chromosome Location    Chromosome: 11; NC_000077.6 (69784036..69795937, complement). Location: 11 B3; 11 42.87 cM
 3D Structure    ModBase 3D Structure for P09690
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Chrnb1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Chrnb1. It may not necessarily be applicable to this product.
 NCBI GI #    160358782
 NCBI GeneID    11443
 NCBI Accession #    NP_033731.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_009601.4 [Other Products]
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 UniProt Primary Accession #    P09690 [Other Products]
 UniProt Secondary Accession #    Q5F292 [Other Products]
 UniProt Related Accession #    P09690 [Other Products]
 Molecular Weight    56,931 Da [Similar Products]
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 NCBI Official Full Name    acetylcholine receptor subunit beta
 NCBI Official Synonym Full Names    cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
 NCBI Official Symbol    Chrnb1 [Similar Products]
 NCBI Official Synonym Symbols   
Acrb; Achr-2
[Similar Products]
 NCBI Protein Information    acetylcholine receptor subunit beta; AChR beta; acetylcholine receptor beta
 UniProt Protein Name    Acetylcholine receptor subunit beta
 Protein Family    Acetylcholine receptor
 UniProt Gene Name    Chrnb1 [Similar Products]
 UniProt Synonym Gene Names    Acrb [Similar Products]
 UniProt Entry Name    ACHB_MOUSE
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 UniProt Comments for Chrnb1    nAChRB1: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in CHRNB1 are a cause of congenital myasthenic syndrome slow-channel type (SCCMS). SCCMS is the most common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. SCCMS is caused by kinetic abnormalities of the AChR, resulting in prolonged endplate currents and prolonged AChR channel opening episodes. Defects in CHRNB1 are a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (CMS-ACHRD). CMS-ACHRD is a postsynaptic congenital myasthenic syndrome. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 1/CHRNB1 sub-subfamily.

Protein type: Channel, ligand-gated; Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; membrane; plasma membrane; integral to membrane; synapse; cell junction

Molecular Function: protein binding; channel activity; acetylcholine receptor activity; ion channel activity; acetylcholine binding; nicotinic acetylcholine-activated cation-selective channel activity; ligand-gated ion channel activity; extracellular ligand-gated ion channel activity

Biological Process: skeletal muscle contraction; behavioral response to nicotine; signal transduction; synaptic transmission, cholinergic; neurological system process; regulation of membrane potential; muscle contraction; transport; neuromuscular synaptic transmission; ion transport; muscle fiber development; postsynaptic membrane organization; transmembrane transport; cation transport
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 Research Articles on Chrnb1    1. The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Chrnb1 recombinant proteinDiseases associated with Chrnb1 recombinant protein
 Products by Pathway  Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Disease Name  Pubmed Publications
 Substance-Related Disorders Antibodies  >5 publications with Chrnb1 and Substance-Related Disorders
 Neoplasms Antibodies  >3 publications with Chrnb1 and Neoplasms
 Carcinoma Antibodies  >3 publications with Chrnb1 and Carcinoma
 Congenital Abnormalities Antibodies  >3 publications with Chrnb1 and Congenital Abnormalities
 Hypokinesia Antibodies  >1 publications with Chrnb1 and Hypokinesia
 Carcinoma, Squamous Cell Antibodies  >1 publications with Chrnb1 and Carcinoma, Squamous Cell
 Hyperplasia Antibodies  >1 publications with Chrnb1 and Hyperplasia
 Lung Neoplasms Antibodies  >1 publications with Chrnb1 and Lung Neoplasms
Organs/Tissues associated with Chrnb1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Joint Antibodies  >2 publications with Chrnb1 and Joint
 Lung Antibodies  >2 publications with Chrnb1 and Lung
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