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Add To Compare List Ache recombinant protein :: Acetylcholinesterase (Ache) Recombinant Protein Catalog # MBS1111867 Unit / Price 0.02 mg (E-Coli) / $390 +1 FREE 8GB USB 0.1 mg (E-Coli) / $650 +1 FREE 8GB USB 0.02 mg (Yeast) / $1,210 +1 FREE 8GB USB 0.1 mg (Yeast) / $1,420 +1 FREE 8GB USB 0.02 mg (Baculovirus) / $1,450 +1 FREE 8GB USB 0.02 mg (Mammalian-Cell) / $1,715 +2 FREE 8GB USB 1 mg (E-Coli) / $1,935 +2 FREE 8GB USB 0.1 mg (Baculovirus) / $2,080 +2 FREE 8GB USB 0.1 mg (Mammalian-Cell) / $2,680 +3 FREE 8GB USB 1 mg (Yeast) / $2,795 +3 FREE 8GB USB 1 mg (Baculovirus) / $4,015 +5 FREE 8GB USB 0.5 mg (Mammalian-Cell) / $6,360 +7 FREE 8GB USB 5x1 mg (E-Coli) / $8,490 +10 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Acetylcholinesterase (Ache), Recombinant Protein Full Product Name Recombinant Rat Acetylcholinesterase (Ache) Product Gene Name Ache recombinant protein[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Sequence Positions 32-614, full length protein Sequence EGREDPQLLV RVRGGQLRGI RLKAPGGPVS AFLGIPFAEP PVGSRRFMPP EPKRPWSGIL DATTFQNVCY QYVDTLYPGF EGTEMWNPNR ELSEDCLYLN VWTPYPRPTS PTPVLIWIYG GGFYSGASSL DVYDGRFLAQ VEGTVLVSMN YRVGTFGFLA LPGSREAPGN VGLLDQRLAL QWVQENIAAF GGDPMSVTLF GESAGAASVG MHILSLPSRS LFHRAVLQSG TPNGPWATVS AGEARRRATL LARLVGCPPG GAGGNDTELI SCLRTRPAQD LVDHEWHVLP QESIFRFSFV PVVDGDFLSD TPDALINTGD FQDLQVLVGV VKDEGSYFLV YGVPGFSKDN ESLISRAQFL AGVRIGVPQA SDLAAEAVVL HYTDWLHPED PAHLRDAMSA VVGDHNVVCP VAQLAGRLAA QGARVYAYIF EHRASTLTWP LWMGVPHGYE IEFIFGLPLD PSLNYTVEER IFAQRLMQYW TNFARTGDPN DPRDSKSPRW PPYTTAAQQY VSLNLKPLEV RRGLRAQTCA FWNRFLPKLL SATDTLDEAE RQWKAEFHRW SSYMVHWKNQ FDHYSKQERC SDL 3D Structure ModBase 3D Structure for P37136 Host E Coli or Yeast or Baculovirus or Mammalian Cell Purity/Purification Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific) Form/Format Lyophilized or liquid (Format to be determined during the manufacturing process) Tag Information This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information. Sterility Sterile filter available upon request. Endotoxin Low endotoxin available upon request. Species Rat Preparation and Storage Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of Ache recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for Ache recombinant protein Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. NCBI/Uniprot data below describe general gene information for Ache. It may not necessarily be applicable to this product. NCBI GI # 25282401 NCBI GeneID 83817 NCBI Accession # NP_742006.1 [Other Products] NCBI GenBank Nucleotide # NM_172009.1 [Other Products] UniProt Primary Accession # P37136 [Other Products] UniProt Related Accession # P37136[Other Products] Molecular Weight 66,268 Da TOP NCBI Official Full Name acetylcholinesterase NCBI Official Synonym Full Names acetylcholinesterase NCBI Official Symbol Ache [Similar Products] NCBI Protein Information acetylcholinesterase UniProt Protein Name Acetylcholinesterase Protein Family Acetylcholinesterase UniProt Gene Name Ache [Similar Products] UniProt Synonym Gene Names AChE [Similar Products] TOP NCBI Summary for Ache catalyzes the hydrolysis of acetylcholine to choline and acetate; plays a role in neuronal development and synapse formation [RGD, Feb 2006] TOP UniProt Comments for Ache Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Research Articles on Ache 1. Paraquat-induced death of hippocampal neurons was partially mediated by AChE variants inducing and cholinergic and gultamatergic transmission disruption. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Pathways associated with Ache recombinant protein Products by Pathway Pathway Diagram Acetylcholine Synthesis Pathway antibodies Acetylcholine Synthesis Pathway Diagram Biogenic Amine Synthesis Pathway antibodies Biogenic Amine Synthesis Pathway Diagram Cholinergic Synapse Pathway antibodies Cholinergic Synapse Pathway Diagram Glycerophospholipid Biosynthesis Pathway antibodies Glycerophospholipid Biosynthesis Pathway Diagram Glycerophospholipid Metabolism Pathway antibodies Glycerophospholipid Metabolism Pathway Diagram Glycerophospholipid Metabolism Pathway antibodies Glycerophospholipid Metabolism Pathway Diagram Metabolism Pathway antibodies Metabolism Pathway Diagram Metabolism Of Lipids And Lipoproteins Pathway antibodies Metabolism Of Lipids And Lipoproteins Pathway Diagram Neuronal System Pathway antibodies Neuronal System Pathway Diagram Neurotransmitter Clearance In The Synaptic Cleft Pathway antibodies Neurotransmitter Clearance In The Synaptic Cleft Pathway Diagram Diseases associated with Ache recombinant protein Disease Name Pubmed Publications Nervous System Diseases Antibodies >372379 publications with Ache and Nervous System Diseases Peripheral Nervous System Diseases Antibodies >34247 publications with Ache and Peripheral Nervous System Diseases Brain Diseases Antibodies >34141 publications with Ache and Brain Diseases Inflammation Antibodies >27676 publications with Ache and Inflammation Necrosis Antibodies >14256 publications with Ache and Necrosis Hypertension Antibodies >12747 publications with Ache and Hypertension Edema Antibodies >12352 publications with Ache and Edema Kidney Diseases Antibodies >11340 publications with Ache and Kidney Diseases Disease Models, Animal Antibodies >10374 publications with Ache and Disease Models, Animal Liver Diseases Antibodies >9859 publications with Ache and Liver Diseases Organs/Tissues associated with Ache recombinant protein Organ/Tissue Name Pubmed Publications Brain Antibodies >41945 publications with Ache and Brain Liver Antibodies >15885 publications with Ache and Liver Eye Antibodies >8995 publications with Ache and Eye Dorsal Root Ganglion Antibodies >5283 publications with Ache and Dorsal Root Ganglion Pancreas Antibodies >5165 publications with Ache and Pancreas Appendix Antibodies >1985 publications with Ache and Appendix Uncharacterized Tissue Antibodies >10 publications with Ache and Uncharacterized Tissue TOP © 2006-24 MyBioSource.com. 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