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ASIC1 recombinant protein :: Acid-sensing ion channel 1 (ASIC1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS968511 ASIC1 recombinant protein
Unit / Price
1 mg (E-Coli)  /  $1,375 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,835 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Acid-sensing ion channel 1 (ASIC1), Recombinant Protein

 Also Known As   

Recombinant Human Acid-sensing ion channel 1 (ASIC1), partial

 Product Gene Name   

ASIC1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    70-427
 Sequence    HYHHVTKLDE VAASQLTFPA VTLCNLNEFR FSQVSKNDLY HAGELLALLN NRYEIPDTQM ADEKQLEILQ DKANFRSFKP KPFNMREFYD RAGHDIRDML LSCHFRGEVC SAEDFKVVFT RYGKCYTFNS GRDGRPRLKT MKGGTGNGLE IMLDIQQDEY LPVWGETDET SFEAGIKVQI HSQDEPPFID QLGFGVAPGF QTFVACQEQR LIYLPPPWGT CKAVTMDSDL DFFDSYSITA CRIDCETRYL VENCNCRMVH MPGDAPYCTP EQYKECADPA LDFLVEKDQE YCVCEMPCNL TRYGKELSMV KIPSKASAKY LAKKFNKSEQ YIGENILVLD IFFEVLNYET IEQKKAYE
 OMIM    602866
 3D Structure    ModBase 3D Structure for P78348
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ASIC1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ASIC1. It may not necessarily be applicable to this product.
 NCBI GI #    21536349
 NCBI GeneID    41
 NCBI Accession #    NP_001086.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001095.3 [Other Products]
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 UniProt Primary Accession #    P78348 [Other Products]
 UniProt Secondary Accession #    P78349; Q96CV2; A3KN86; E5KBL7 [Other Products]
 UniProt Related Accession #    P78348 [Other Products]
 Molecular Weight    62,700 Da
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 NCBI Official Full Name    acid-sensing ion channel 1 isoform b
 NCBI Official Synonym Full Names    acid sensing ion channel subunit 1
 NCBI Official Symbol    ASIC1 [Similar Products]
 NCBI Official Synonym Symbols   
ASIC; ACCN2; BNaC2
[Similar Products]
 NCBI Protein Information    acid-sensing ion channel 1
 UniProt Protein Name    Acid-sensing ion channel 1
 UniProt Synonym Protein Names   
Amiloride-sensitive cation channel 2, neuronal; Brain sodium channel 2
 Protein Family    Acid-sensing ion channel
 UniProt Gene Name    ASIC1 [Similar Products]
 UniProt Synonym Gene Names    ACCN2; BNAC2; BNaC2 [Similar Products]
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 NCBI Summary for ASIC1    This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
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 UniProt Comments for ASIC1    Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
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 Research Articles on ASIC1    1. the data demonstrate a functional link between ASICs and [Ca(2+)]i/RhoA pathway, which contributes to the acidity-induced epithelial-mesenchymal transition.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ASIC1 recombinant proteinDiseases associated with ASIC1 recombinant protein
 Reference Product  PubMed Publications
 ASIC2 recombinant protein  >30 publications with ASIC1 and ASIC2
 PICK1 recombinant protein  >3 publications with ASIC1 and PICK1
 Disease Name  Pubmed Publications
 Pain Antibodies  >18 publications with ASIC1 and Pain
 Inflammation Antibodies  >9 publications with ASIC1 and Inflammation
 Neoplasms Antibodies  >6 publications with ASIC1 and Neoplasms
 Nerve Degeneration Antibodies  >2 publications with ASIC1 and Nerve Degeneration
 Cardiovascular Diseases Antibodies  >2 publications with ASIC1 and Cardiovascular Diseases
 Drug Toxicity Antibodies  >1 publications with ASIC1 and Drug Toxicity
 Reperfusion Injury Antibodies  >1 publications with ASIC1 and Reperfusion Injury
 Hypertension Antibodies  >1 publications with ASIC1 and Hypertension
Organs/Tissues associated with ASIC1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >25 publications with ASIC1 and Brain
 Muscle Antibodies  >9 publications with ASIC1 and Muscle
 Bone Antibodies  >3 publications with ASIC1 and Bone
 Intestine Antibodies  >3 publications with ASIC1 and Intestine
 Embryonic Tissue Antibodies  >2 publications with ASIC1 and Embryonic Tissue
 Stomach Antibodies  >1 publications with ASIC1 and Stomach
 Eye Antibodies  >1 publications with ASIC1 and Eye
 Ovary Antibodies  >1 publications with ASIC1 and Ovary
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