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ACO1 recombinant protein :: Aconitase-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144183 ACO1 recombinant protein
Unit / Price
0.001 mg  /  $140 +1 FREE 8GB USB
0.005 mg  /  $205 +1 FREE 8GB USB
0.05 mg  /  $1,220 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aconitase-1 (ACO1), Recombinant Protein

 Also Known As   

Recombinant Human Aconitase-1

 Product Synonym Names    ACO1 Human; Aconitase-1 Human Recombinant; Onitase 1 Soluble; IRP1; IREB1; IREBP; Citrate hydro-lyase; Iron regulatory protein 1; Ferritin repressor protein; Iron-responsive element-binding protein 1; ACONS; Aconitate Hydratase; EC 4.2.1.3; Aconitase
 Product Gene Name   

ACO1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MGSMSN PFAH LAEPLDPVQP GKKFFNLNKL EDSRYGRLPF SIRVLLEAAI RNCDEFLVKK QDIENILHWN VTQHKNIEVP FKPARVILQD FTGVPAVVDF AAMRDAVKKL GGDPEKINPV CPADLVIDHS IQVDFNRRAD SLQKNQDLEF ERNRERFEFL KWGSQAFHNM RIIPPGSGII HQVNLEYLAR VVFDQDGYYY PDSLVGTDSH TTMIDGLGIL GWGVGGIEAE AVMLGQPISM VLPQVIGYRL MGKPHPLVTS TDIVLTITKH LRQVGVVGKF VEFFGPGVAQ LSIADRATIA NMCPEYGATA AFFPVDEVSI TYLVQTGRDE EKLKYIKKYL QAVGMFRDFN DPSQDPDFTQ VVELDLKTVV PCCSGPKRPQ DKVAVSDMKK DFESCLGAKQ GFKGFQVAPE HHNDHKTFIY DNTEFTLAHG SVVIAAITSC TNTSNPSVML GAGLLAKKAV DAGLNVMPYI KTSLSPGSGV VTYYLQESGV MPYLSQLGFD VVGYGCMTCI GNSGPLPEPV VEAITQGDLV AVGVLSGNRN FEGRVHPNTR ANYLASPPLV IAYAIAGTIR IDFEKEPLGV NAKGQQVFLK DIWPTRDEIQ AVERQYVIPG MFKEVYQKIE TVNESWNALA TPSDKLFFWN SKSTYIKSPP FFENLTLDLQ PPKSIVDAYV LLNLGDSVTT DHISPAGNIA RNSPAARYLT NRGLTPREFN SYGSRRGNDA VMARGTFANI RLLNRFLNKQ APQTIHLPSG EILDVFDAAE RYQQAGLPLI VLAGKEYGAG SSRDWAAKGP FLLGIKAVLA ESYERIHRSN LVGMGVIPLE YLPGENADAL GLTGQERYTI IIPENLKPQM KVQVKLDTGK TFQAVMRFDT DVELTYFLNG GILNYMIRKM AK
 OMIM    100880
 3D Structure    ModBase 3D Structure for P21399
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    The ACO1 protein solution (0.5mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0)2mM DTT, 100mM NaCl and 10% glycerol.
Sterile Filtered clear solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
 Other Notes    Small volumes of ACO1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ACO1 recombinant protein

   Description: ACO1 produced in E Coli is a single, non-glycosylated polypeptide chain containing 912 amino acids (1-889a.a.) and having a molecular mass of 100.8kDa.ACO1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: ACO1 has a part in an iron sensor. ACO1 catalyzes the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle, a non-redox-active process.
 Product Categories/Family for ACO1 recombinant protein    ENZYMES; Enzymes
NCBI/Uniprot data below describe general gene information for ACO1. It may not necessarily be applicable to this product.
 NCBI GI #    507834063
 NCBI GeneID    48
 NCBI Accession #    NP_001265281.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278352.1 [Other Products]
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 UniProt Primary Accession #    P21399 [Other Products]
 UniProt Secondary Accession #    Q14652; Q5VZA7; D3DRK7 [Other Products]
 UniProt Related Accession #    P21399 [Other Products]
 Molecular Weight    98,399 Da
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 NCBI Official Full Name    cytoplasmic aconitate hydratase
 NCBI Official Synonym Full Names    aconitase 1, soluble
 NCBI Official Symbol    ACO1 [Similar Products]
 NCBI Official Synonym Symbols   
IRP1; ACONS; HEL60; IREB1; IREBP; IREBP1
[Similar Products]
 NCBI Protein Information    cytoplasmic aconitate hydratase; IRE-BP 1; aconitate hydratase, cytoplasmic; citrate hydro-lyase; epididymis luminal protein 60; ferritin repressor protein; iron regulatory protein 1; iron-responsive element binding protein 1; iron-responsive element-binding protein 1
 UniProt Protein Name    Cytoplasmic aconitate hydratase
 UniProt Synonym Protein Names   
Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1
 Protein Family    Aconitate hydratase
 UniProt Gene Name    ACO1 [Similar Products]
 UniProt Synonym Gene Names    IREB1; Aconitase; IRP1; IRE-BP 1 [Similar Products]
 UniProt Entry Name    ACOC_HUMAN
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 NCBI Summary for ACO1    The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]
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 UniProt Comments for ACO1    IREB1: Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. Belongs to the aconitase/IPM isomerase family.

Protein type: Translation; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Lyase; Carbohydrate Metabolism - citrate (TCA) cycle; RNA-binding; EC 4.2.1.3; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 9p21.1

Cellular Component: Golgi apparatus; mitochondrion; endoplasmic reticulum; cytoplasm; cytosol

Molecular Function: protein binding; iron-responsive element binding; RNA binding; metal ion binding; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity

Biological Process: regulation of translation; cellular iron ion homeostasis; tricarboxylic acid cycle; citrate metabolic process; response to iron(II) ion; intestinal absorption; post-embryonic development
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 Research Articles on ACO1    1. MitoNEET governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/IRP1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACO1 recombinant proteinPathways associated with ACO1 recombinant protein
 Reference Product  PubMed Publications
 ACO2 recombinant protein  >24 publications with ACO1 and ACO2
 IDH1 recombinant protein  >4 publications with ACO1 and IDH1
 IDH2 recombinant protein  >2 publications with ACO1 and IDH2
 FTH1 recombinant protein  >1 publications with ACO1 and FTH1
 Products by Pathway  Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram
Diseases associated with ACO1 recombinant proteinOrgans/Tissues associated with ACO1 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with ACO1 and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with ACO1 and Brain Diseases
 Fatty Liver Antibodies  >2 publications with ACO1 and Fatty Liver
 Lung Neoplasms Antibodies  >1 publications with ACO1 and Lung Neoplasms
 Lung Diseases Antibodies  >1 publications with ACO1 and Lung Diseases
 Anemia Antibodies  >1 publications with ACO1 and Anemia
 Nerve Degeneration Antibodies  >1 publications with ACO1 and Nerve Degeneration
 Fibrosis Antibodies  >1 publications with ACO1 and Fibrosis
 Kidney Diseases Antibodies  >1 publications with ACO1 and Kidney Diseases
 Inflammation Antibodies  >1 publications with ACO1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with ACO1 and Liver
 Blood Antibodies  >3 publications with ACO1 and Blood
 Brain Antibodies  >3 publications with ACO1 and Brain
 Skin Antibodies  >2 publications with ACO1 and Skin
 Kidney Antibodies  >2 publications with ACO1 and Kidney
 Muscle Antibodies  >2 publications with ACO1 and Muscle
 Vascular Antibodies  >2 publications with ACO1 and Vascular
 Lung Antibodies  >2 publications with ACO1 and Lung
 Embryonic Tissue Antibodies  >1 publications with ACO1 and Embryonic Tissue
 Eye Antibodies  >1 publications with ACO1 and Eye
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