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ATF1 recombinant protein :: Activating Transcription Factor 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2030124 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
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Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $260 +1 FREE 8GB USB
0.1 mg  /  $400 +1 FREE 8GB USB
0.2 mg  /  $495 +1 FREE 8GB USB
0.5 mg  /  $955 +1 FREE 8GB USB
1 mg  /  $1,415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activating Transcription Factor 1 (ATF1), Recombinant Protein

 Also Known As   

Recombinant Activating Transcription Factor 1 (ATF1)

 Product Gene Name   

ATF1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.
MGSSHHHHH H SSGLVPRGSH MASMTGGQQM GRGSEF- DSHKSTTS ETAPQPGSAV QGAHISHIAQ QVSSLSESEE SQDSSDSIGS SQKAHGILAR RPSYRKILKD LSSEDTRGRK GDGENSGVSA AVTSMSVPTP IYQTSSGQYI AIAPNGALQL ASPGTDGVQG LQTLTMTNSG STQQGTTILQ YAQTSDGQQI LVPSNQVVVQ TASGDMQTYQ IRTTPSATSL PQTVVMTSPV TLTSQTTKTD DPQ
 OMIM    123803
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 Host    Host: E Coli
Source: Prokaryotic expression
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 Purity/Purification    >95%
 Form/Format    Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
 Concentration    6.2 (lot specific)
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 Predicted Molecular Mass    25.8kDa
 Accurate Molecular Mass (KD)    30kDa
 Endotoxin    <1.0EU per 1ug (determined by the LAL method)
 Expression System    Prokaryotic expression
 Tag    two N-terminal Tags, His-tag and T7-tag
 Organism Species    Homo sapiens (Human)
 Fragment    Asp3~Gln213
 Usage    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of ATF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for ATF1 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-Page of ATF1 recombinant protein    ATF1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for ATF1. It may not necessarily be applicable to this product.
 NCBI GI #    119578555
 NCBI GeneID    466
 NCBI Accession #    EAW58151.1 [Other Products]
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 UniProt Secondary Accession #    P25168; Q9H4A8; B4DRF9 [Other Products]
 UniProt Related Accession #    P18846; AAB25878 [Other Products]
 Molecular Weight    15,295 Da
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 NCBI Official Full Name    activating transcription factor 1
 NCBI Official Synonym Full Names    activating transcription factor 1
 NCBI Official Symbol    ATF1 [Similar Products]
 NCBI Official Synonym Symbols   
TREB36; EWS-ATF1; FUS/ATF-1
[Similar Products]
 NCBI Protein Information    cyclic AMP-dependent transcription factor ATF-1
 UniProt Protein Name    Cyclic AMP-dependent transcription factor ATF-1
 UniProt Synonym Protein Names   
Activating transcription factor 1; Protein TREB36
 Protein Family    Alcohol O-acetyltransferase
 UniProt Gene Name    ATF1 [Similar Products]
 UniProt Synonym Gene Names    cAMP-dependent transcription factor ATF-1 [Similar Products]
 UniProt Entry Name    ATF1_HUMAN
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 NCBI Summary for ATF1    This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
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 UniProt Comments for ATF1    ATF-1: a transcription factor that is a member of the leucine zipper family. Forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. Binds the Tax-responsive element (TRE) of HTLV-I. Activated downstream of IL-1. c-Src and TRAF6 are mediators of IL-1-induced AP-1 activation. Plays an important role in the trans-activation of the MHC class II trans-activator (CIITA) promoter III in B cells.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: nucleoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; protein heterodimerization activity; protein complex binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; response to organic cyclic substance; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; cellular protein complex assembly; toll-like receptor signaling pathway; response to cobalt ion; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway; positive regulation of DNA replication
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 Research Articles on ATF1    1. EWSR1-ATF1 fusion gene was found in hyalinizing clear cell carcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ATF1 recombinant proteinPathways associated with ATF1 recombinant protein
 Reference Product  PubMed Publications
 JUN recombinant protein  >73 publications with ATF1 and JUN
 FOS recombinant protein  >28 publications with ATF1 and FOS
 CREBBP recombinant protein  >7 publications with ATF1 and CREBBP
 RPS6KA4 recombinant protein  >4 publications with ATF1 and RPS6KA4
 CRTC3 recombinant protein  >1 publications with ATF1 and CRTC3
 FOSL2 recombinant protein  >1 publications with ATF1 and FOSL2
 MAPK14 recombinant protein  >1 publications with ATF1 and MAPK14
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 CREB Phosphorylation Pathway antibodies  CREB Phosphorylation Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with ATF1 recombinant proteinOrgans/Tissues associated with ATF1 recombinant protein
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >13 publications with ATF1 and Lung Neoplasms
 Necrosis Antibodies  >12 publications with ATF1 and Necrosis
 Lung Diseases Antibodies  >10 publications with ATF1 and Lung Diseases
 Neoplasm Metastasis Antibodies  >10 publications with ATF1 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >10 publications with ATF1 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >10 publications with ATF1 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >8 publications with ATF1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >6 publications with ATF1 and Breast Neoplasms
 Inflammation Antibodies  >6 publications with ATF1 and Inflammation
 Cardiovascular Diseases Antibodies  >4 publications with ATF1 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >47 publications with ATF1 and Blood
 Bone Antibodies  >23 publications with ATF1 and Bone
 Lung Antibodies  >20 publications with ATF1 and Lung
 Brain Antibodies  >20 publications with ATF1 and Brain
 Skin Antibodies  >20 publications with ATF1 and Skin
 Muscle Antibodies  >19 publications with ATF1 and Muscle
 Lymph Node Antibodies  >15 publications with ATF1 and Lymph Node
 Salivary Gland Antibodies  >10 publications with ATF1 and Salivary Gland
 Vascular Antibodies  >10 publications with ATF1 and Vascular
 Liver Antibodies  >10 publications with ATF1 and Liver
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