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ATF3 recombinant protein :: Activating Transcription Factor 3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2030178 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $275 +1 FREE 8GB USB
0.1 mg  /  $430 +1 FREE 8GB USB
0.2 mg  /  $525 +1 FREE 8GB USB
0.5 mg  /  $1,015 +1 FREE 8GB USB
1 mg  /  $1,515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activating Transcription Factor 3 (ATF3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Activating Transcription Factor 3 (ATF3)

 Product Gene Name   

ATF3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603148
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 Host    E. coli
 Species Reactivity    Mouse
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 Purity/Purification    >95%
 Form/Format    100mM NaHCO3, 500mM NaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300
 Concentration    Original Concentration: 200g/mL (lot specific)
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 Source    Prokaryotic expression
 Residues    Met1~Ser181
 Tags    Two N-terminal Tags, His-tag and GST-tag
 Subcellular Location    Nucleus
 Traits    Freeze-dried powder
 Predicted isoelectric point    8.8
 Predicted Molecular Mass    50.7kDa
 Accurate Molecular Mass    51kDa as determined by SDS-PAGE reducing conditions
 Usage    Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex
    
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8C for one month.
Aliquot and store at -80C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of ATF3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for ATF3 recombinant protein   

Positive Control, Immunogen, SDS-PAGE, WB

(May be suitable for use in other assays to be determined by the end user.)

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 SDS-Page of ATF3 recombinant protein    ATF3 recombinant protein SDS-Page image
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 Sequence of ATF3 recombinant protein    ATF3 recombinant protein Sequence image
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 Identification of ATF3 recombinant protein    ATF3 recombinant protein Identification image
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NCBI/Uniprot data below describe general gene information for ATF3. It may not necessarily be applicable to this product.
 NCBI GI #    442422
 NCBI GeneID    467
 NCBI Accession #    AAA20506.1 [Other Products]
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 UniProt Secondary Accession #    Q5VTZ2; Q6ICQ9; Q7Z566; Q8WYM6 [Other Products]
 UniProt Related Accession #    P18847 [Other Products]
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 NCBI Official Full Name    activating transcription factor 3
 NCBI Official Synonym Full Names    activating transcription factor 3
 NCBI Official Symbol    ATF3 [Similar Products]
 NCBI Protein Information    cyclic AMP-dependent transcription factor ATF-3
 UniProt Protein Name    Cyclic AMP-dependent transcription factor ATF-3
 UniProt Synonym Protein Names   
Activating transcription factor 3
 Protein Family    Activating transcription factor
 UniProt Gene Name    ATF3 [Similar Products]
 UniProt Synonym Gene Names    cAMP-dependent transcription factor ATF-3 [Similar Products]
 UniProt Entry Name    ATF3_HUMAN
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 NCBI Summary for ATF3    This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
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 UniProt Comments for ATF3    ATF-3: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters. Belongs to the bZIP family. ATF subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 1q32.3

Cellular Component: nucleoplasm; nucleolus; nucleus

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; transcription corepressor activity; transcription factor activity

Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; transcription, DNA-dependent; unfolded protein response; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; gluconeogenesis
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 Research Articles on ATF3    1. Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ATF3 recombinant proteinPathways associated with ATF3 recombinant protein
 Reference Product  PubMed Publications
 JUN recombinant protein  >214 publications with ATF3 and JUN
 ATF4 recombinant protein  >76 publications with ATF3 and ATF4
 DDIT3 recombinant protein  >64 publications with ATF3 and DDIT3
 ATF2 recombinant protein  >25 publications with ATF3 and ATF2
 TP53 recombinant protein  >19 publications with ATF3 and TP53
 JUNB recombinant protein  >17 publications with ATF3 and JUNB
 SMAD3 recombinant protein  >6 publications with ATF3 and SMAD3
 CREB1 recombinant protein  >4 publications with ATF3 and CREB1
 MAPK8 recombinant protein  >3 publications with ATF3 and MAPK8
 SMARCA4 recombinant protein  >1 publications with ATF3 and SMARCA4
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 ATF4 Activates Genes Pathway antibodies  ATF4 Activates Genes Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hypertrophy Model Pathway antibodies  Hypertrophy Model Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 PERK Regulates Gene Expression Pathway antibodies  PERK Regulates Gene Expression Pathway Diagram
Diseases associated with ATF3 recombinant proteinOrgans/Tissues associated with ATF3 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >156 publications with ATF3 and Nervous System Diseases
 Disease Models, Animal Antibodies  >128 publications with ATF3 and Disease Models, Animal
 Pain Antibodies  >112 publications with ATF3 and Pain
 Inflammation Antibodies  >110 publications with ATF3 and Inflammation
 Peripheral Nervous System Diseases Antibodies  >77 publications with ATF3 and Peripheral Nervous System Diseases
 Cardiovascular Diseases Antibodies  >55 publications with ATF3 and Cardiovascular Diseases
 Necrosis Antibodies  >53 publications with ATF3 and Necrosis
 Lung Diseases Antibodies  >31 publications with ATF3 and Lung Diseases
 Liver Diseases Antibodies  >28 publications with ATF3 and Liver Diseases
 Breast Neoplasms Antibodies  >26 publications with ATF3 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >174 publications with ATF3 and Nerve
 Ganglia Antibodies  >128 publications with ATF3 and Ganglia
 Brain Antibodies  >98 publications with ATF3 and Brain
 Blood Antibodies  >96 publications with ATF3 and Blood
 Liver Antibodies  >71 publications with ATF3 and Liver
 Muscle Antibodies  >64 publications with ATF3 and Muscle
 Bone Antibodies  >53 publications with ATF3 and Bone
 Lung Antibodies  >48 publications with ATF3 and Lung
 Vascular Antibodies  >47 publications with ATF3 and Vascular
 Skin Antibodies  >44 publications with ATF3 and Skin
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