NP_001273443.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
136,323 Da
NCBI Official Full Name
activating transcription factor 7-interacting protein 1 isoform 3
NCBI Official Synonym Full Names
activating transcription factor 7 interacting protein
NCBI Protein Information
activating transcription factor 7-interacting protein 1
UniProt Protein Name
Activating transcription factor 7-interacting protein 1
UniProt Synonym Protein Names
ATF-interacting protein; ATF-IP; ATF7-interacting protein; ATFa-associated modulator; hAM; MBD1-containing chromatin-associated factor 1; P621
UniProt Synonym Gene Names
NCBI Summary for ATF7IP
ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]
UniProt Comments for ATF7IP
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.
Research Articles on ATF7IP
Precautions
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Products associated with ATF7IP recombinant protein
Pathways associated with ATF7IP recombinant protein
Diseases associated with ATF7IP recombinant protein
Organs/Tissues associated with ATF7IP recombinant protein
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