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Abr recombinant protein :: Active breakpoint cluster region-related protein (Abr), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1366544 Abr recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Active breakpoint cluster region-related protein (Abr), partial, Recombinant Protein

 Also Known As   

Recombinant Mouse Active breakpoint cluster region-related protein (Abr), partial

 Product Synonym Names    Active breakpoint cluster region-related protein
 Product Gene Name   

Abr recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q5SSL4
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Abr recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Abr. It may not necessarily be applicable to this product.
 NCBI GI #    600971669
 NCBI GeneID    109934
 NCBI Accession #    NP_001278115.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001291186.1 [Other Products]
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 UniProt Primary Accession #    Q5SSL4 [Other Products]
 UniProt Secondary Accession #    Q3U5G0; Q3UQJ6; Q3UY38; Q5SYJ5; Q5SYJ7; Q5SYJ8; Q5SYJ9; Q6PCY1; Q6PDH3 [Other Products]
 UniProt Related Accession #    Q5SSL4 [Other Products]
 Molecular Weight    93,773 Da
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 NCBI Official Full Name    active breakpoint cluster region-related protein isoform 4
 NCBI Official Synonym Full Names    active BCR-related gene
 NCBI Official Symbol    Abr [Similar Products]
 NCBI Protein Information    active breakpoint cluster region-related protein
 UniProt Protein Name    Active breakpoint cluster region-related protein
 Protein Family    Active breakpoint cluster region-related protein
 UniProt Gene Name    Abr [Similar Products]
 UniProt Entry Name    ABR_MOUSE
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 UniProt Comments for Abr    ABR: GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Ser/Thr (non-receptor); GAPs, Rac/Rho; GAPs; Kinase, protein; ATYPICAL group; BCR family

Cellular Component: membrane; plasma membrane; intracellular; cytosol

Molecular Function: Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; GTPase activator activity

Biological Process: negative regulation of neutrophil degranulation; inner ear morphogenesis; negative regulation of inflammatory response; positive regulation of phagocytosis; regulation of Rho protein signal transduction; response to lipopolysaccharide; brain development; actin cytoskeleton organization and biogenesis; neuromuscular process controlling balance; signal transduction; negative regulation of cell migration; positive regulation of GTPase activity
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 Research Articles on Abr    1. Loss of abr expression causes defects in spine development.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Abr recombinant proteinDiseases associated with Abr recombinant protein
 Products by Pathway  Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 NRAGE Signals Death Through JNK Pathway antibodies  NRAGE Signals Death Through JNK Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
 Cyclic AMP Biosynthesis Pathway antibodies  Cyclic AMP Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2202 publications with Abr and Nervous System Diseases
 Disease Models, Animal Antibodies  >282 publications with Abr and Disease Models, Animal
 Immune System Diseases Antibodies  >144 publications with Abr and Immune System Diseases
 Congenital Abnormalities Antibodies  >119 publications with Abr and Congenital Abnormalities
 Weight Loss Antibodies  >79 publications with Abr and Weight Loss
 Abnormalities, Multiple Antibodies  >62 publications with Abr and Abnormalities, Multiple
 Inflammation Antibodies  >58 publications with Abr and Inflammation
 Carcinoma Antibodies  >38 publications with Abr and Carcinoma
 Nerve Degeneration Antibodies  >37 publications with Abr and Nerve Degeneration
 Kidney Diseases Antibodies  >36 publications with Abr and Kidney Diseases
Organs/Tissues associated with Abr recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2945 publications with Abr and Brain
 Inner Ear Antibodies  >1011 publications with Abr and Inner Ear
 Blood Antibodies  >381 publications with Abr and Blood
 Bone Antibodies  >225 publications with Abr and Bone
 Muscle Antibodies  >121 publications with Abr and Muscle
 Heart Antibodies  >94 publications with Abr and Heart
 Eye Antibodies  >86 publications with Abr and Eye
 Skin Antibodies  >57 publications with Abr and Skin
 Kidney Antibodies  >54 publications with Abr and Kidney
 Joint Antibodies  >43 publications with Abr and Joint
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