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INHBA recombinant protein :: Activin-A Active Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144102 INHBA recombinant protein
Unit / Price
0.001 mg  /  $140 +1 FREE 8GB USB
0.005 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $1,510 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activin-A Active (INHBA), Recombinant Protein

 Also Known As   

Recombinant Human Activin-A Active

 Product Synonym Names    Activin-A Human Plant-Active; Activin-A Human Recombinant, Plant-Active; Inhba; Inhibin beta A; FSH releasing protein; Activin A Plant-Active
 Product Gene Name   

INHBA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    HHHHHHGLEC DGKVNICCKK QFFVSFKDIG WNDWIIAPSG YHANYCEGEC PSHIAGTSGS SLSFHSTVIN HYRMRGHSPF ANLKSCCVPT KLRPMSMLYY DDGQNIIKKD IQNMIVEECG CS
 OMIM    147290
 3D Structure    ModBase 3D Structure for P08476
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 Host    Nicotiana benthamiana
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 Purity/Purification    Greater than 98% as obsereved by SDS-PAGE.
 Form/Format    Active form Activin-A was lyophilized from a concentrated 1mg/ml protein solution containing 50mM Tris-HCl pH-7.4
Lyophilized freeze dried powder.
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 Solubility    INHBA protein should be reconstituted in distilled water to a concentration of 50 ug /ml. Due to the protein nature, dimmers and multimers may be observed.
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 Preparation and Storage    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Repeated freezing and thawing is not recommended.
 Other Notes    Small volumes of INHBA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for INHBA recombinant protein

   Description: Active form Activin-A Human Recombinant produced in Plant is a homodimeric, glycosylated, polypeptide chain containing 2 x 116 amino acids and having a molecular weight of 27.4kDa.The Active form Activin-A is fused to a 6-His tag at N-terminus and purified by standard chromatographic techniques.

Introduction: Activins are homodimers or heterodimers of the different beta subunit isoforms, part of the TGFbeta family. Mature Activin A has two 116 amino acids residues betaA subunits (betaA-betaA). Activin displays an extensive variety of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, haematopoiesis, and reproductive physiology. Activins takes part in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Cells that are identified to express Activin A include fibroblasts, endothelial cells, hepatocytes, vascular smooth muscle cells, macrophages, keratinocytes, osteoclasts, bone marrow monocytes, prostatic epithelium, neurons, chondrocytes, osteoblasts, Leydig cells, Sertoli cells, and ovarian granulosa cells.
 Product Categories/Family for INHBA recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Activin
NCBI/Uniprot data below describe general gene information for INHBA. It may not necessarily be applicable to this product.
 NCBI GI #    4504699
 NCBI GeneID    3624
 NCBI Accession #    NP_002183.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002192.2 [Other Products]
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 UniProt Primary Accession #    P08476 [Other Products]
 UniProt Secondary Accession #    Q14599 [Other Products]
 UniProt Related Accession #    P08476 [Other Products]
 Molecular Weight    47,442 Da [Similar Products]
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 NCBI Official Full Name    inhibin beta A chain
 NCBI Official Synonym Full Names    inhibin, beta A
 NCBI Official Symbol    INHBA [Similar Products]
 NCBI Official Synonym Symbols   
EDF; FRP
[Similar Products]
 NCBI Protein Information    inhibin beta A chain; FSH-releasing protein; Inhibin, beta-1; activin beta-A chain; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; inhibin, beta A (activin A, activin AB alpha polypeptide)
 UniProt Protein Name    Inhibin beta A chain
 UniProt Synonym Protein Names   
Activin beta-A chain; Erythroid differentiation protein; EDF
 Protein Family    Inhibin
 UniProt Gene Name    INHBA [Similar Products]
 UniProt Synonym Gene Names    EDF [Similar Products]
 UniProt Entry Name    INHBA_HUMAN
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 NCBI Summary for INHBA    The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq, Jul 2008]
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 UniProt Comments for INHBA    INHBA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p15-p13

Cellular Component: extracellular region

Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; hormone activity; peptide hormone binding; cytokine activity; transforming growth factor beta receptor binding

Biological Process: positive regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; activin receptor signaling pathway; mesodermal cell differentiation; defense response; palate development; negative regulation of cell cycle; negative regulation of interferon-gamma biosynthetic process; odontogenesis; negative regulation of cell proliferation; cell surface receptor linked signal transduction; cell-cell signaling; ovarian follicle development; hair follicle development; erythrocyte differentiation; cell cycle arrest; cell differentiation; negative regulation of B cell differentiation; hemoglobin biosynthetic process; response to drug; nervous system development; regulation of follicle-stimulating hormone secretion; positive regulation of erythrocyte differentiation; male gonad development; progesterone secretion; negative regulation of follicle-stimulating hormone secretion; regulation of transcription from RNA polymerase II promoter; negative regulation of macrophage differentiation; regulation of MAPKKK cascade; negative regulation of phosphorylation; hemopoietic progenitor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of follicle-stimulating hormone secretion; negative regulation of cell growth; cell development; growth; G1/S transition of mitotic cell cycle
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 Research Articles on INHBA    1. Activin A is an anti-lymphangiogenic factor, but because of its pleiotropic effects on cell mobility it appears not suitable as a pharmacological target.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with INHBA recombinant proteinPathways associated with INHBA recombinant protein
 Reference Product  PubMed Publications
 INHBB recombinant protein  >23 publications with INHBA and INHBB
 INHA recombinant protein  >18 publications with INHBA and INHA
 FST recombinant protein  >11 publications with INHBA and FST
 FSTL3 recombinant protein  >3 publications with INHBA and FSTL3
 FSHB recombinant protein  >1 publications with INHBA and FSHB
 INHBC recombinant protein  >1 publications with INHBA and INHBC
 ACVR2B recombinant protein  >1 publications with INHBA and ACVR2B
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Antagonism Of Activin By Follistatin Pathway antibodies  Antagonism Of Activin By Follistatin Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Glycoprotein Hormones Pathway antibodies  Glycoprotein Hormones Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
Diseases associated with INHBA recombinant proteinOrgans/Tissues associated with INHBA recombinant protein
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >8 publications with INHBA and Adenocarcinoma
 Necrosis Antibodies  >7 publications with INHBA and Necrosis
 Disease Models, Animal Antibodies  >6 publications with INHBA and Disease Models, Animal
 Kidney Diseases Antibodies  >5 publications with INHBA and Kidney Diseases
 Inflammation Antibodies  >5 publications with INHBA and Inflammation
 Lung Neoplasms Antibodies  >3 publications with INHBA and Lung Neoplasms
 Pre-Eclampsia Antibodies  >3 publications with INHBA and Pre-Eclampsia
 Cardiovascular Diseases Antibodies  >2 publications with INHBA and Cardiovascular Diseases
 Hypertrophy Antibodies  >2 publications with INHBA and Hypertrophy
 Infertility, Male Antibodies  >2 publications with INHBA and Infertility, Male
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >23 publications with INHBA and Ovary
 Bone Antibodies  >17 publications with INHBA and Bone
 Blood Antibodies  >17 publications with INHBA and Blood
 Kidney Antibodies  >7 publications with INHBA and Kidney
 Lung Antibodies  >7 publications with INHBA and Lung
 Skin Antibodies  >6 publications with INHBA and Skin
 Vascular Antibodies  >6 publications with INHBA and Vascular
 Stomach Antibodies  >6 publications with INHBA and Stomach
 Placenta Antibodies  >6 publications with INHBA and Placenta
 Brain Antibodies  >5 publications with INHBA and Brain
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