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ACVR2A recombinant protein :: Activin A Receptor Type II A (ACVR2A) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2009906 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $270 +1 FREE 8GB USB
0.1 mg  /  $420 +1 FREE 8GB USB
0.2 mg  /  $515 +1 FREE 8GB USB
0.5 mg  /  $990 +1 FREE 8GB USB
1 mg  /  $1,475 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activin A Receptor Type II A (ACVR2A), Recombinant Protein

 Also Known As   

Recombinant Activin A Receptor Type II A (ACVR2A)

 Product Gene Name   

ACVR2A recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Activin A Receptor Type II A (ACVR2A) (MBS2003517)
Antigen: Activin A Receptor Type II A (ACVR2A) (MBS2009906)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and GST-tag, its sequence is listed below.
MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF -A ILGRSETQEC LFFNANWEKD RTNQTGVEPC YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CVEKKDSPEV YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPP
 Chromosome Location    Chromosome: 2; NC_000002.11 (148602086..148688396). Location: 2q22.3
 OMIM    102581
 3D Structure    ModBase 3D Structure for P27037
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Homo sapiens (Human)
 Expression System    Prokaryotic expression
 Residues    Ala20~Pro135 (Accession # P27037) with two N-terminal Tags, His-tag and GST-tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of ACVR2A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ACVR2A recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for ACVR2A recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of ACVR2A recombinant protein    ACVR2A recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for ACVR2A. It may not necessarily be applicable to this product.
 NCBI GI #    518828583
 NCBI GeneID    92
 NCBI Accession #    NP_001265508.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278579.1 [Other Products]
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 UniProt Primary Accession #    P27037 [Other Products]
 UniProt Secondary Accession #    Q53TH4; Q6NWV2; Q92474; B2RAB8; D3DP85 [Other Products]
 UniProt Related Accession #    P27037 [Other Products]
 Molecular Weight    40.5kDa
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 NCBI Official Full Name    activin receptor type-2A isoform 1
 NCBI Official Synonym Full Names    activin A receptor, type IIA
 NCBI Official Symbol    ACVR2A [Similar Products]
 NCBI Official Synonym Symbols   
ACVR2; ACTRII
[Similar Products]
 NCBI Protein Information    activin receptor type-2A
 UniProt Protein Name    Activin receptor type-2A
 UniProt Synonym Protein Names   
Activin receptor type IIA
 Protein Family    Activin receptor
 UniProt Gene Name    ACVR2A [Similar Products]
 UniProt Synonym Gene Names    ACVR2; ACTR-IIA; ACTRIIA [Similar Products]
 UniProt Entry Name    AVR2A_HUMAN
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 NCBI Summary for ACVR2A    This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
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 UniProt Comments for ACVR2A    ACVR2A: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active.

Protein type: Membrane protein, integral; Protein kinase, TKL; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Kinase, protein; Motility/polarity/chemotaxis; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 2q22.3

Cellular Component: cell surface; integral to plasma membrane; cytoplasm; plasma membrane; receptor complex

Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; activin receptor activity; protein self-association; growth factor binding; metal ion binding; activin binding; coreceptor activity; transmembrane receptor protein serine/threonine kinase activity; ATP binding; PDZ domain binding; receptor signaling protein serine/threonine kinase activity

Biological Process: embryonic skeletal development; positive regulation of erythrocyte differentiation; regulation of BMP signaling pathway; activin receptor signaling pathway; Sertoli cell proliferation; gastrulation with mouth forming second; positive regulation of bone mineralization; protein amino acid phosphorylation; anterior/posterior pattern formation; BMP signaling pathway; positive regulation of osteoblast differentiation; positive regulation of activin receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; mesoderm development; spermatogenesis; sperm ejaculation; regulation of nitric-oxide synthase activity; positive regulation of protein amino acid phosphorylation; determination of left/right symmetry; penile erection
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 Research Articles on ACVR2A    1. ACVR2A was identified as a subnetwork component in functional association network analysis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACVR2A recombinant proteinPathways associated with ACVR2A recombinant protein
 Reference Product  PubMed Publications
 BMP2 recombinant protein  >5 publications with ACVR2A and BMP2
 BMP7 recombinant protein  >5 publications with ACVR2A and BMP7
 SMAD4 recombinant protein  >1 publications with ACVR2A and SMAD4
 INHA recombinant protein  >1 publications with ACVR2A and INHA
 INHBB recombinant protein  >1 publications with ACVR2A and INHBB
 ACVRL1 recombinant protein  >1 publications with ACVR2A and ACVRL1
 ACVR1B recombinant protein  >1 publications with ACVR2A and ACVR1B
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with ACVR2A recombinant proteinOrgans/Tissues associated with ACVR2A recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with ACVR2A and Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with ACVR2A and Cardiovascular Diseases
 Congenital Abnormalities Antibodies  >3 publications with ACVR2A and Congenital Abnormalities
 Nervous System Diseases Antibodies  >2 publications with ACVR2A and Nervous System Diseases
 Craniofacial Abnormalities Antibodies  >2 publications with ACVR2A and Craniofacial Abnormalities
 Disease Models, Animal Antibodies  >2 publications with ACVR2A and Disease Models, Animal
 Nervous System Malformations Antibodies  >1 publications with ACVR2A and Nervous System Malformations
 Heart Defects, Congenital Antibodies  >1 publications with ACVR2A and Heart Defects, Congenital
 Fibrosis Antibodies  >1 publications with ACVR2A and Fibrosis
 Breast Neoplasms Antibodies  >1 publications with ACVR2A and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >4 publications with ACVR2A and Placenta
 Blood Antibodies  >4 publications with ACVR2A and Blood
 Embryonic Tissue Antibodies  >3 publications with ACVR2A and Embryonic Tissue
 Ovary Antibodies  >3 publications with ACVR2A and Ovary
 Pancreas Antibodies  >2 publications with ACVR2A and Pancreas
 Liver Antibodies  >1 publications with ACVR2A and Liver
 Mammary Gland Antibodies  >1 publications with ACVR2A and Mammary Gland
 Testis Antibodies  >1 publications with ACVR2A and Testis
 Eye Antibodies  >1 publications with ACVR2A and Eye
 Vascular Antibodies  >1 publications with ACVR2A and Vascular
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