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INHBB recombinant protein :: Activin-B Active Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS145165 INHBB recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,500 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activin-B Active (INHBB), Recombinant Protein

 Also Known As   

Recombinant Human Activin-B Active

 Product Synonym Names    Activin B Human Active; Activin-B Human Recombinant, Active; Inhibin beta B (activin AB beta polypeptide); Inhibin; beta-2; Activin beta-B chain; MGC157939; Activin B Active
 Product Gene Name   

INHBB recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147390
 3D Structure    ModBase 3D Structure for P09529
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 Host    Nicotiana benthamiana plant
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 Purity/Purification    Greater than 97.0% as determined by Analysis by SDS-PAGE.
 Form/Format    Lyophilized from 1mg/ml solution in 0.05M Tris-HCl buffer pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Activin B in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    The biological activity of Activin B is measured by its ability to inhibit mouse plasmacytoma cell line (MPC-11) cells proliferation. EC50 <5ng/ml is required to stimulate a half-maximal response at cytokine saturation. Note: Since applications vary, each investigator should titrate the reagent to obtain optimal results.
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 Preparation and Storage    Lyophilized Activin B although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Activin B should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of INHBB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for INHBB recombinant protein

   Description: Activin B human Recombinant produced in Nicotiana benthamiana plant is a beta-B single chain (aa 293-406) containing 123 amino acids (molecular formula C615H910N178O177S12). Activin B is fused to a 10-His-tag at the N-terminal having the total molecular mass of 14kDa and purified by standard chromatographic techniques.

Introduction: Inhibins are dimeric peptide hormones produced by female ovarian granulose cells and male Sertoli cells as well as a variety of other tissues. Inhibins have two isoforms, A and B, with the same alpha subunit but different beta subunits. Inhibin A is a dimer of alpha and beta A subunits, inhibin B is a dimer of alpha and beta B subunits.Inhibins are thought to inhibit the production of follicle-stimulating hormone (FSH) by the pituitary gland. In addition, Inhibins are also thought to play a role in the control of gametogenesis, and embryonic and fetal development.
 Product Categories/Family for INHBB recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Activin
NCBI/Uniprot data below describe general gene information for INHBB. It may not necessarily be applicable to this product.
 NCBI GI #    154813204
 NCBI GeneID    3625
 NCBI Accession #    NP_002184.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002193.2 [Other Products]
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 UniProt Primary Accession #    P09529 [Other Products]
 UniProt Secondary Accession #    Q53T31; Q8N1D3 [Other Products]
 UniProt Related Accession #    P09529 [Other Products]
 Molecular Weight    45,122 Da [Similar Products]
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 NCBI Official Full Name    inhibin beta B chain preproprotein
 NCBI Official Synonym Full Names    inhibin, beta B
 NCBI Official Symbol    INHBB [Similar Products]
 NCBI Protein Information    inhibin beta B chain; Inhibin, beta-2; activin AB beta polypeptide; activin beta-B chain
 UniProt Protein Name    Inhibin beta B chain
 UniProt Synonym Protein Names   
Activin beta-B chain
 Protein Family    Inhibin
 UniProt Gene Name    INHBB [Similar Products]
 UniProt Entry Name    INHBB_HUMAN
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 NCBI Summary for INHBB    The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq, Jul 2008]
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 UniProt Comments for INHBB    INHBB: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.

Protein type: Cytokine; Secreted, signal peptide; Secreted; Cell development/differentiation

Chromosomal Location of Human Ortholog: 2cen-q13

Cellular Component: extracellular space; perinuclear region of cytoplasm; extracellular region

Molecular Function: protein binding; protein homodimerization activity; growth factor activity; hormone activity; cytokine activity; transforming growth factor beta receptor binding; host cell surface receptor binding

Biological Process: fat cell differentiation; activin receptor signaling pathway; defense response; negative regulation of hepatocyte growth factor biosynthetic process; cellular response to starvation; negative regulation of follicle-stimulating hormone secretion; negative regulation of insulin secretion; regulation of apoptosis; ovarian follicle development; cellular response to insulin stimulus; response to mechanical stimulus; regulation of MAPKKK cascade; positive regulation of follicle-stimulating hormone secretion; cell differentiation; cell development; oocyte development; growth
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 Research Articles on INHBB    1. Activin A, B, and AB have similar effects on steroidogenesis in human granulosa cells; in contrast, activin AC is not biologically active and does not act as a competitive antagonist.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with INHBB recombinant proteinPathways associated with INHBB recombinant protein
 Reference Product  PubMed Publications
 INHBA recombinant protein  >23 publications with INHBB and INHBA
 INHA recombinant protein  >17 publications with INHBB and INHA
 FST recombinant protein  >8 publications with INHBB and FST
 FSHB recombinant protein  >3 publications with INHBB and FSHB
 INHBC recombinant protein  >3 publications with INHBB and INHBC
 INHBE recombinant protein  >2 publications with INHBB and INHBE
 ACVR1B recombinant protein  >2 publications with INHBB and ACVR1B
 ACVR2A recombinant protein  >1 publications with INHBB and ACVR2A
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Antagonism Of Activin By Follistatin Pathway antibodies  Antagonism Of Activin By Follistatin Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Glycoprotein Hormones Pathway antibodies  Glycoprotein Hormones Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Biosynthesis Pathway antibodies  Peptide Hormone Biosynthesis Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
Diseases associated with INHBB recombinant proteinOrgans/Tissues associated with INHBB recombinant protein
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >7 publications with INHBB and Adenocarcinoma
 Infertility, Male Antibodies  >7 publications with INHBB and Infertility, Male
 Ovarian Neoplasms Antibodies  >6 publications with INHBB and Ovarian Neoplasms
 Weight Loss Antibodies  >4 publications with INHBB and Weight Loss
 Neoplasm Metastasis Antibodies  >4 publications with INHBB and Neoplasm Metastasis
 Prostatic Neoplasms Antibodies  >4 publications with INHBB and Prostatic Neoplasms
 Disease Models, Animal Antibodies  >3 publications with INHBB and Disease Models, Animal
 Breast Neoplasms Antibodies  >3 publications with INHBB and Breast Neoplasms
 Congenital Abnormalities Antibodies  >3 publications with INHBB and Congenital Abnormalities
 Oligospermia Antibodies  >3 publications with INHBB and Oligospermia
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >21 publications with INHBB and Testis
 Brain Antibodies  >10 publications with INHBB and Brain
 Uterus Antibodies  >8 publications with INHBB and Uterus
 Liver Antibodies  >6 publications with INHBB and Liver
 Prostate Antibodies  >5 publications with INHBB and Prostate
 Pancreas Antibodies  >5 publications with INHBB and Pancreas
 Kidney Antibodies  >4 publications with INHBB and Kidney
 Eye Antibodies  >3 publications with INHBB and Eye
 Nerve Antibodies  >2 publications with INHBB and Nerve
 Lung Antibodies  >2 publications with INHBB and Lung
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