NP_001103674.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,226 Da
NCBI Official Full Name
activin receptor type-1
NCBI Official Synonym Full Names
activin A receptor, type 1
NCBI Official Synonym Symbols
ALK2; Acvr; Alk8; SKR1; Alk-2; Tsk7L; ActR-I; ActRIA; Acvrlk2; D330013D15Rik [Similar Products]
NCBI Protein Information
activin receptor type-1; TSR-I; TSK-7L; activin receptor type I; TGF-B superfamily receptor type I; serine/threonine-protein kinase receptor R1
UniProt Protein Name
Activin receptor type-1
UniProt Synonym Protein Names
Activin receptor type I; ACTR-I; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I; TSK-7L
UniProt Synonym Gene Names
UniProt Entry Name
ACVR1_MOUSE
UniProt Comments for Acvr1
ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Protein type: Protein kinase, Ser/Thr (receptor); Kinase, protein; Membrane protein, integral; EC 2.7.11.30; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily
Cellular Component: membrane; apical part of cell; integral to plasma membrane; integral to membrane; activin receptor complex
Molecular Function: protein homodimerization activity; metal ion binding; nucleotide binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; transferase activity; protein serine/threonine kinase activity; activin receptor activity, type I; transforming growth factor beta receptor activity, type I; transforming growth factor beta binding; growth factor binding; transferase activity, transferring phosphorus-containing groups; activin binding; kinase activity; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: heart development; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; gastrulation; protein amino acid phosphorylation; germ cell development; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; mesoderm development; neural crest cell migration; pharyngeal system development; in utero embryonic development; peptidyl-threonine phosphorylation; gastrulation with mouth forming second; positive regulation of bone mineralization; negative regulation of signal transduction; patterning of blood vessels; negative regulation of activin receptor signaling pathway; positive regulation of osteoblast differentiation; embryonic development; mesoderm formation; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; regulation of ossification; determination of left/right symmetry; phosphorylation; urogenital system development; G1/S transition of mitotic cell cycle
Research Articles on Acvr1
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Pathways associated with Acvr1 recombinant protein
Diseases associated with Acvr1 recombinant protein
Organs/Tissues associated with Acvr1 recombinant protein
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