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Acvr2a recombinant protein :: Activin receptor type-2A (Acvr2a) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS968574 Acvr2a recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $510 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $680 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $835 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $915 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,025 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,050 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,050 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,070 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,520 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,560 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,635 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,035 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activin receptor type-2A (Acvr2a), Recombinant Protein

 Also Known As   

Recombinant Mouse Activin receptor type-2A (Acvr2a), partial

 Product Gene Name   

Acvr2a recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    20-135aa, Extracellular domain
 Sequence    AILGRSETQE CLFFNANWER DRTNQTGVEP CYGDKDKRRH CFATWKNISG SIEIVKQGCW LDDINCYDRT DCIEKKDSPE VYFCCCEGNM CNEKFSYFPE MEVTQPTSNP VTPKPP
 3D Structure    ModBase 3D Structure for P27038
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Acvr2a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Acvr2a recombinant protein

   This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine
threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
NCBI/Uniprot data below describe general gene information for Acvr2a. It may not necessarily be applicable to this product.
 NCBI GI #    160358785
 NCBI GeneID    11480
 NCBI Accession #    NP_031422.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_007396.4 [Other Products]
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 UniProt Primary Accession #    P27038 [Other Products]
 UniProt Related Accession #    P27038 [Other Products]
 Molecular Weight    57,890 Da
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 NCBI Official Full Name    activin receptor type-2A
 NCBI Official Synonym Full Names    activin receptor IIA
 NCBI Official Symbol    Acvr2a [Similar Products]
 NCBI Official Synonym Symbols   
Acvr2; ActrIIa; TactrII
[Similar Products]
 NCBI Protein Information    activin receptor type-2A
 UniProt Protein Name    Activin receptor type-2A
 UniProt Synonym Protein Names   
Activin receptor type IIA; ACTR-IIA
 Protein Family    Activin receptor
 UniProt Gene Name    Acvr2a [Similar Products]
 UniProt Synonym Gene Names    Acvr2; ACTR-IIA [Similar Products]
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 UniProt Comments for Acvr2a    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555).
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 Research Articles on Acvr2a    1. Anti-ActRII blockade is an effective intervention against cancer cachexia providing benefit even in the presence of anti-cancer therapies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Acvr2a recombinant proteinPathways associated with Acvr2a recombinant protein
 Reference Product  PubMed Publications
 Smad2 recombinant protein  >9 publications with Acvr2a and Smad2
 Bmp7 recombinant protein  >6 publications with Acvr2a and Bmp7
 Bmp2 recombinant protein  >6 publications with Acvr2a and Bmp2
 Smad1 recombinant protein  >5 publications with Acvr2a and Smad1
 Smad4 recombinant protein  >4 publications with Acvr2a and Smad4
 Smad5 recombinant protein  >3 publications with Acvr2a and Smad5
 Smad3 recombinant protein  >2 publications with Acvr2a and Smad3
 Inhba recombinant protein  >1 publications with Acvr2a and Inhba
 Products by Pathway  Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
Diseases associated with Acvr2a recombinant proteinOrgans/Tissues associated with Acvr2a recombinant protein
 Disease Name  Pubmed Publications
 Microsatellite Instability Antibodies  >5 publications with Acvr2a and Microsatellite Instability
 Hypertension Antibodies  >4 publications with Acvr2a and Hypertension
 Inflammation Antibodies  >4 publications with Acvr2a and Inflammation
 Nervous System Diseases Antibodies  >3 publications with Acvr2a and Nervous System Diseases
 Disease Models, Animal Antibodies  >3 publications with Acvr2a and Disease Models, Animal
 Congenital Abnormalities Antibodies  >3 publications with Acvr2a and Congenital Abnormalities
 Anemia Antibodies  >3 publications with Acvr2a and Anemia
 Lung Diseases Antibodies  >3 publications with Acvr2a and Lung Diseases
 Brain Diseases Antibodies  >2 publications with Acvr2a and Brain Diseases
 Craniofacial Abnormalities Antibodies  >2 publications with Acvr2a and Craniofacial Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with Acvr2a and Lung
 Embryonic Tissue Antibodies  >4 publications with Acvr2a and Embryonic Tissue
 Ovary Antibodies  >4 publications with Acvr2a and Ovary
 Bone Marrow Antibodies  >3 publications with Acvr2a and Bone Marrow
 Liver Antibodies  >3 publications with Acvr2a and Liver
 Brain Antibodies  >3 publications with Acvr2a and Brain
 Pancreas Antibodies  >2 publications with Acvr2a and Pancreas
 Heart Antibodies  >2 publications with Acvr2a and Heart
 Joint Antibodies  >1 publications with Acvr2a and Joint
 Eye Antibodies  >1 publications with Acvr2a and Eye
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