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Add To Compare List Acvr2a recombinant protein :: Activin receptor type-2A (Acvr2a) Recombinant Protein Catalog # MBS968574 Unit / Price 0.05 mg (E-Coli) / $625 +1 FREE 8GB USB 0.2 mg (E-Coli) / $800 +1 FREE 8GB USB 0.5 mg (E-Coli) / $880 +1 FREE 8GB USB 0.05 mg (Baculovirus) / $975 +1 FREE 8GB USB 0.2 mg (Yeast) / $1,070 +1 FREE 8GB USB 0.5 mg (Yeast) / $1,165 +1 FREE 8GB USB 0.1 mg (Baculovirus) / $1,190 +1 FREE 8GB USB 1 mg (E-Coli) / $1,195 +1 FREE 8GB USB 0.05 mg (Mammalian-Cell) / $1,215 +1 FREE 8GB USB 0.5 mg (Baculovirus) / $1,710 +2 FREE 8GB USB 1 mg (Yeast) / $1,755 +2 FREE 8GB USB 0.1 mg (Mammalian-Cell) / $1,835 +2 FREE 8GB USB 1 mg (Baculovirus) / $2,225 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Activin receptor type-2A (Acvr2a), Recombinant Protein Full Product Name Recombinant Mouse Activin receptor type-2A (Acvr2a), partial Product Gene Name Acvr2a recombinant protein[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Sequence Positions 20-135aa, Extracellular domain Sequence AILGRSETQE CLFFNANWER DRTNQTGVEP CYGDKDKRRH CFATWKNISG SIEIVKQGCW LDDINCYDRT DCIEKKDSPE VYFCCCEGNM CNEKFSYFPE MEVTQPTSNP VTPKPP 3D Structure ModBase 3D Structure for P27038 Host E Coli or Yeast or Baculovirus or Mammalian Cell Purity/Purification Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific) Form/Format Lyophilized or liquid (Format to be determined during the manufacturing process) Tag Information This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information. Sterility Sterile filter available upon request. Endotoxin Low endotoxin available upon request. Species Mouse Preparation and Storage Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of Acvr2a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for Acvr2a recombinant protein This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serinethreonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. NCBI/Uniprot data below describe general gene information for Acvr2a. It may not necessarily be applicable to this product. NCBI GI # 160358785 NCBI GeneID 11480 NCBI Accession # NP_031422.3 [Other Products] NCBI GenBank Nucleotide # NM_007396.4 [Other Products] UniProt Primary Accession # P27038 [Other Products] UniProt Related Accession # P27038[Other Products] Molecular Weight 57,890 Da TOP NCBI Official Full Name activin receptor type-2A NCBI Official Synonym Full Names activin receptor IIA NCBI Official Symbol Acvr2a [Similar Products] NCBI Official Synonym Symbols Acvr2; ActrIIa; TactrII [Similar Products] NCBI Protein Information activin receptor type-2A UniProt Protein Name Activin receptor type-2A UniProt Synonym Protein Names Activin receptor type IIA; ACTR-IIA Protein Family Activin receptor UniProt Gene Name Acvr2a [Similar Products] UniProt Synonym Gene Names Acvr2; ACTR-IIA [Similar Products] TOP TOP UniProt Comments for Acvr2a On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555). Research Articles on Acvr2a 1. Anti-ActRII blockade is an effective intervention against cancer cachexia providing benefit even in the presence of anti-cancer therapies. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with Acvr2a recombinant protein Reference Product PubMed Publications Smad2 recombinant protein >9 publications with Acvr2a and Smad2 Bmp7 recombinant protein >6 publications with Acvr2a and Bmp7 Bmp2 recombinant protein >6 publications with Acvr2a and Bmp2 Smad1 recombinant protein >5 publications with Acvr2a and Smad1 Smad4 recombinant protein >4 publications with Acvr2a and Smad4 Smad5 recombinant protein >3 publications with Acvr2a and Smad5 Smad3 recombinant protein >2 publications with Acvr2a and Smad3 Inhba recombinant protein >1 publications with Acvr2a and Inhba Pathways associated with Acvr2a recombinant protein Products by Pathway Pathway Diagram Activin Signaling Pathway antibodies Activin Signaling Pathway Diagram Activin Signaling Pathway antibodies Activin Signaling Pathway Diagram BMP Signaling Pathway antibodies BMP Signaling Pathway Diagram BMP Signaling Pathway antibodies BMP Signaling Pathway Diagram Cytokine-cytokine Receptor Interaction Pathway antibodies Cytokine-cytokine Receptor Interaction Pathway Diagram Cytokine-cytokine Receptor Interaction Pathway antibodies Cytokine-cytokine Receptor Interaction Pathway Diagram Signal Transduction Pathway antibodies Signal Transduction Pathway Diagram Signaling By Activin Pathway antibodies Signaling By Activin Pathway Diagram Signaling By BMP Pathway antibodies Signaling By BMP Pathway Diagram Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram Diseases associated with Acvr2a recombinant protein Disease Name Pubmed Publications Microsatellite Instability Antibodies >5 publications with Acvr2a and Microsatellite Instability Hypertension Antibodies >4 publications with Acvr2a and Hypertension Inflammation Antibodies >4 publications with Acvr2a and Inflammation Nervous System Diseases Antibodies >3 publications with Acvr2a and Nervous System Diseases Disease Models, Animal Antibodies >3 publications with Acvr2a and Disease Models, Animal Congenital Abnormalities Antibodies >3 publications with Acvr2a and Congenital Abnormalities Anemia Antibodies >3 publications with Acvr2a and Anemia Lung Diseases Antibodies >3 publications with Acvr2a and Lung Diseases Brain Diseases Antibodies >2 publications with Acvr2a and Brain Diseases Craniofacial Abnormalities Antibodies >2 publications with Acvr2a and Craniofacial Abnormalities Organs/Tissues associated with Acvr2a recombinant protein Organ/Tissue Name Pubmed Publications Lung Antibodies >4 publications with Acvr2a and Lung Embryonic Tissue Antibodies >4 publications with Acvr2a and Embryonic Tissue Ovary Antibodies >4 publications with Acvr2a and Ovary Bone Marrow Antibodies >3 publications with Acvr2a and Bone Marrow Liver Antibodies >3 publications with Acvr2a and Liver Brain Antibodies >3 publications with Acvr2a and Brain Pancreas Antibodies >2 publications with Acvr2a and Pancreas Heart Antibodies >2 publications with Acvr2a and Heart Joint Antibodies >1 publications with Acvr2a and Joint Eye Antibodies >1 publications with Acvr2a and Eye TOP © 2006-24 MyBioSource.com. 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