NP_031422.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
57,890 Da
NCBI Official Full Name
activin receptor type-2A
NCBI Official Synonym Full Names
activin receptor IIA
NCBI Protein Information
activin receptor type-2A
UniProt Protein Name
Activin receptor type-2A
UniProt Synonym Protein Names
Activin receptor type IIA; ACTR-IIA
UniProt Synonym Gene Names
UniProt Entry Name
AVR2A_MOUSE
UniProt Comments for Acvr2a
ACVR2A: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active.
Protein type: EC 2.7.11.30; Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (receptor); Motility/polarity/chemotaxis; Membrane protein, integral; TKL group; STKR family; Type2 subfamily
Cellular Component: cell surface; cytoplasm; receptor complex
Molecular Function: activin binding; activin receptor activity; activin receptor activity, type II; coreceptor activity; growth factor binding; PDZ domain binding; protein binding; protein self-association; protein serine/threonine kinase activity
Biological Process: activin receptor signaling pathway; anterior/posterior pattern formation; BMP signaling pathway; determination of left/right symmetry; embryonic skeletal development; gastrulation with mouth forming second; male gonad development; mesoderm development; penile erection; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of erythrocyte differentiation; positive regulation of follicle-stimulating hormone secretion; positive regulation of osteoblast differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of BMP signaling pathway; regulation of nitric-oxide synthase activity; regulation of signal transduction; Sertoli cell proliferation; sperm ejaculation; spermatogenesis
Research Articles on Acvr2a
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Products associated with Acvr2a recombinant protein
Pathways associated with Acvr2a recombinant protein
Diseases associated with Acvr2a recombinant protein
Organs/Tissues associated with Acvr2a recombinant protein
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