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Acvr2b recombinant protein :: Activin receptor type-2B (Acvr2b) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS967885 Acvr2b recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activin receptor type-2B (Acvr2b), Recombinant Protein

 Also Known As   

Recombinant Mouse Activin receptor type-2B (Acvr2b)

 Product Synonym Names    Activin receptor type-2B; EC=2.7.11.30; Activin receptor type IIB; ACTR-IIB
 Product Gene Name   

Acvr2b recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    19-137
 Sequence    SG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEPG GPEVTYEPPP TAPTLLT
 3D Structure    ModBase 3D Structure for P27040
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Acvr2b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Acvr2b. It may not necessarily be applicable to this product.
 NCBI GI #    6680634
 NCBI GeneID    11481
 NCBI Accession #    NP_031423.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007397.2 [Other Products]
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 UniProt Primary Accession #    P27040 [Other Products]
 UniProt Secondary Accession #    Q3KQI1 [Other Products]
 UniProt Related Accession #    P27040 [Other Products]
 Molecular Weight    56,853 Da
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 NCBI Official Full Name    activin receptor type-2B
 NCBI Official Synonym Full Names    activin receptor IIB
 NCBI Official Symbol    Acvr2b [Similar Products]
 NCBI Official Synonym Symbols   
ActRIIB
[Similar Products]
 NCBI Protein Information    activin receptor type-2B; ACTR-IIB; activin receptor type IIB
 UniProt Protein Name    Activin receptor type-2B
 UniProt Synonym Protein Names   
Activin receptor type IIB; ACTR-IIB
 Protein Family    Activin receptor
 UniProt Gene Name    Acvr2b [Similar Products]
 UniProt Synonym Gene Names    ACTR-IIB [Similar Products]
 UniProt Entry Name    AVR2B_MOUSE
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 UniProt Comments for Acvr2b    ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor.

Protein type: Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Kinase, protein; EC 2.7.11.30; Protein kinase, TKL; TKL group; STKR family; Type2 subfamily

Cellular Component: protein complex; membrane; cell; cytoplasm; integral to membrane; plasma membrane; receptor complex

Molecular Function: metal ion binding; nucleotide binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta binding; growth factor binding; transferase activity, transferring phosphorus-containing groups; protein serine/threonine/tyrosine kinase activity; activin binding; kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: heart development; regulation of signal transduction; palate development; signal transduction; protein amino acid phosphorylation; post-embryonic development; BMP signaling pathway; anterior/posterior pattern formation; positive regulation of activin receptor signaling pathway; regulation of transcription, DNA-dependent; embryonic foregut morphogenesis; lymphangiogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway; pancreas development; response to glucose stimulus; mesoderm development; kidney development; skeletal development; gastrulation with mouth forming second; positive regulation of bone mineralization; pattern specification process; odontogenesis of dentine-containing teeth; organ growth; positive regulation of osteoblast differentiation; insulin secretion; skeletal morphogenesis; activation of protein kinase activity; blood vessel remodeling; determination of left/right symmetry; phosphorylation; lung development
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 Research Articles on Acvr2b    1. ActRIIB inhibition enhanced energy expenditure only at ambient temperature or in the cold, where nonshivering thermogenesis is minimal, suggesting that brown fat activation plays a prominent role in the metabolic actions of ActRIIB inhibition.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Acvr2b recombinant proteinPathways associated with Acvr2b recombinant protein
 Reference Product  PubMed Publications
 Bmp2 recombinant protein  >8 publications with Acvr2b and Bmp2
 Bmpr1a recombinant protein  >8 publications with Acvr2b and Bmpr1a
 Smad2 recombinant protein  >8 publications with Acvr2b and Smad2
 Bmpr1b recombinant protein  >6 publications with Acvr2b and Bmpr1b
 Smad3 recombinant protein  >6 publications with Acvr2b and Smad3
 Inhba recombinant protein  >1 publications with Acvr2b and Inhba
 Smad4 recombinant protein  >1 publications with Acvr2b and Smad4
 Smad5 recombinant protein  >1 publications with Acvr2b and Smad5
 Tdgf1 recombinant protein  >1 publications with Acvr2b and Tdgf1
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram
Diseases associated with Acvr2b recombinant proteinOrgans/Tissues associated with Acvr2b recombinant protein
 Disease Name  Pubmed Publications
 Heart Defects, Congenital Antibodies  >5 publications with Acvr2b and Heart Defects, Congenital
 Situs Inversus Antibodies  >4 publications with Acvr2b and Situs Inversus
 Heterotaxy Syndrome Antibodies  >3 publications with Acvr2b and Heterotaxy Syndrome
 Nervous System Diseases Antibodies  >2 publications with Acvr2b and Nervous System Diseases
 Disease Models, Animal Antibodies  >2 publications with Acvr2b and Disease Models, Animal
 Breast Neoplasms Antibodies  >2 publications with Acvr2b and Breast Neoplasms
 Hypertrophy Antibodies  >2 publications with Acvr2b and Hypertrophy
 Skin Diseases Antibodies  >2 publications with Acvr2b and Skin Diseases
 Liver Diseases Antibodies  >1 publications with Acvr2b and Liver Diseases
 Glucose Intolerance Antibodies  >1 publications with Acvr2b and Glucose Intolerance
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >6 publications with Acvr2b and Heart
 Bone Marrow Antibodies  >3 publications with Acvr2b and Bone Marrow
 Embryonic Tissue Antibodies  >3 publications with Acvr2b and Embryonic Tissue
 Lung Antibodies  >2 publications with Acvr2b and Lung
 Testis Antibodies  >2 publications with Acvr2b and Testis
 Brain Antibodies  >2 publications with Acvr2b and Brain
 Pituitary Gland Antibodies  >1 publications with Acvr2b and Pituitary Gland
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