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ACOT8 recombinant protein :: Acyl-coenzyme A thioesterase 8 (ACOT8) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1105373 ACOT8 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $725 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $975 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $995 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,070 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,145 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,230 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,250 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,290 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,520 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,800 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,870 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,965 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,395 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Acyl-coenzyme A thioesterase 8 (ACOT8), Recombinant Protein

 Also Known As   

Recombinant Human Acyl-coenzyme A thioesterase 8 (ACOT8)

 Product Gene Name   

ACOT8 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-319aa, Full length protein
 Sequence    MSSPQAPEDG QGCGDRGDPP GDLRSVLVTT VLNLEPLDED LFRGRHYWVP AKRLFGGQIV GQALVAAAKS VSEDVHVHSL HCYFVRAGDP KLPVLYQVER TRTGSSFSVR SVKAVQHGKP IFICQASFQQ AQPSPMQHQF SMPTVPPPEE LLDCETLIDQ YLRDPNLQKR YPLALNRIAA QEVPIEIKPV NPSPLSQLQR MEPKQMFWVR ARGYIGEGDM KMHCCVAAYI SDYAFLGTAL LPHQWQHKVH FMVSLDHSMW FHAPFRADHW MLYECESPWA GGSRGLVHGR LWRQDGVLAV TCAQEGVIRV KPQVSESKL
 OMIM    608123
 3D Structure    ModBase 3D Structure for O14734
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ACOT8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ACOT8 recombinant protein

   This protein is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. Multiple transcript variants encoding several different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for ACOT8. It may not necessarily be applicable to this product.
 NCBI GI #    34577075
 NCBI GeneID    10005
 NCBI Accession #    NP_005460.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005469.3 [Other Products]
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 UniProt Primary Accession #    O14734 [Other Products]
 UniProt Secondary Accession #    O15261; Q17RX4 [Other Products]
 UniProt Related Accession #    O14734 [Other Products]
 Molecular Weight    35,914 Da
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 NCBI Official Full Name    acyl-coenzyme A thioesterase 8
 NCBI Official Synonym Full Names    acyl-CoA thioesterase 8
 NCBI Official Symbol    ACOT8 [Similar Products]
 NCBI Official Synonym Symbols   
hTE; NAP1; PTE1; PTE2; PTE-1; PTE-2; HNAACTE; hACTE-III
[Similar Products]
 NCBI Protein Information    acyl-coenzyme A thioesterase 8
 UniProt Protein Name    Acyl-coenzyme A thioesterase 8
 UniProt Synonym Protein Names   
Choloyl-coenzyme A thioesterase; HIV-Nef-associated acyl-CoA thioesterase; PTE-2; Peroxisomal acyl-coenzyme A thioester hydrolase 1; PTE-1; Peroxisomal long-chain acyl-CoA thioesterase 1; Thioesterase II; hACTE-III; hACTEIII; hTE
 Protein Family    Acyl-coenzyme A thioesterase
 UniProt Gene Name    ACOT8 [Similar Products]
 UniProt Synonym Gene Names    ACTEIII; PTE1; PTE2; Acyl-CoA thioesterase 8; PTE-1; hACTE-III; hACTEIII; hTE [Similar Products]
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 NCBI Summary for ACOT8    The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]
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 UniProt Comments for ACOT8    Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:9299485, PubMed:9153233, PubMed:15194431). Competes with bile acid CoA:amino acid N-acyltransferase (BAAT) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (C2 to C20) (PubMed:9299485, PubMed:9153233). Inactive towards substrates with more than C20 aliphatic chains (PubMed:9153233). Involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431).
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 Research Articles on ACOT8    1. In summary, lipolytic enzyme ACOT8 is frequently upregulated in HCC clinical specimens. More importantly, ACOT8 silencing leads to inhibition of cell growth in HCC in vitro.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACOT8 recombinant proteinPathways associated with ACOT8 recombinant protein
 Reference Product  PubMed Publications
 ACOT4 recombinant protein  >2 publications with ACOT8 and ACOT4
 Products by Pathway  Pathway Diagram
 Beta-oxidation Of Pristanoyl-CoA Pathway antibodies  Beta-oxidation Of Pristanoyl-CoA Pathway Diagram
 Beta-oxidation Of Very Long Chain Fatty Acids Pathway antibodies  Beta-oxidation Of Very Long Chain Fatty Acids Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Peroxisomal Lipid Metabolism Pathway antibodies  Peroxisomal Lipid Metabolism Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
Diseases associated with ACOT8 recombinant proteinOrgans/Tissues associated with ACOT8 recombinant protein
 Disease Name  Pubmed Publications
 Death Antibodies  >2 publications with ACOT8 and Death
 Fatty Liver Antibodies  >1 publications with ACOT8 and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with ACOT8 and Blood
 Lymph Antibodies  >1 publications with ACOT8 and Lymph
 Kidney Antibodies  >1 publications with ACOT8 and Kidney
 Liver Antibodies  >1 publications with ACOT8 and Liver
 Lung Antibodies  >1 publications with ACOT8 and Lung
 Lymph Node Antibodies  >1 publications with ACOT8 and Lymph Node
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