NP_001268783.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
65,155 Da
NCBI Official Full Name
acyloxyacyl hydrolase isoform 2 preproprotein
NCBI Official Synonym Full Names
acyloxyacyl hydrolase
NCBI Protein Information
acyloxyacyl hydrolase
UniProt Protein Name
Acyloxyacyl hydrolase
NCBI Summary for Aoah
This genes encodes an enzyme that catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides. The encoded protein modulates host inflammatory response to gram-negative bacteria. The proprotein is further cleaved into a large and small chain that interact in a heterodimer. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2013]
UniProt Comments for Aoah
Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPS) (PubMed:12810692, PubMed:15155618, PubMed:17322564, PubMed:19860560). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (PubMed:17322564, PubMed:19860560, PubMed:28622363). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (PubMed:18779055).
Research Articles on Aoah
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Diseases associated with Aoah recombinant protein
Organs/Tissues associated with Aoah recombinant protein
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