NP_005197.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,906 Da
NCBI Official Full Name
adapter molecule crk isoform b
NCBI Official Synonym Full Names
CRK proto-oncogene, adaptor protein
NCBI Official Synonym Symbols
NCBI Protein Information
adapter molecule crk
UniProt Protein Name
Adapter molecule crk
UniProt Synonym Protein Names
Proto-oncogene c-Crk; p38
NCBI Summary for CRK
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for CRK
Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
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Products associated with CRK recombinant protein
Pathways associated with CRK recombinant protein
Diseases associated with CRK recombinant protein
Organs/Tissues associated with CRK recombinant protein
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