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AHCY recombinant protein :: Adenosylhomocysteinase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS958818
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $945 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,075 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,270 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,320 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,360 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,440 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,955 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,995 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,190 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,575 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Adenosylhomocysteinase (AHCY), Recombinant Protein

 Also Known As   

Recombinant Human Adenosylhomocysteinase

 Product Synonym Names    S-adenosyl-L-homocysteine hydrolase
 Product Gene Name   

AHCY recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-432aa; Full Length
 Sequence    SDKLPYKVAD IGLAAWGRKA LDIAENEMPG LMRMRERYSA SKPLKGARIA GCLHMTVETA VLIETLVTLG AEVQWSSCNI FSTQDHAAAA IAKAGIPVYA WKGETDEEYL WCIEQTLYFK DGPLNMILDD GGDLTNLIHT KYPQLLPGIR GISEETTTGV HNLYKMMANG ILKVPAINVN DSVTKSKFDN LYGCRESLID GIKRATDVMI AGKVAVVAGY GDVGKGCAQA LRGFGARVII TEIDPINALQ AAMEGYEVTT MDEACQEGNI FVTTTGCIDI ILGRHFEQMK DDAIVCNIGH FDVEIDVKWL NENAVEKVNI KPQVDRYRLK NGRRIILLAE GRLVNLGCAM GHPSFVMSNS FTNQVMAQIE LWTHPDKYPV GVHFLPKKLD EAVAEAHLGK LNVKLTKLTE KQAQYLGMSC DGPFKPDHYR Y
 OMIM    180960
 3D Structure    ModBase 3D Structure for P23526
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of AHCY recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AHCY recombinant protein

   Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
 Product Categories/Family for AHCY recombinant protein    Metabolism
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 SDS-PAGE of AHCY recombinant protein    AHCY recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for AHCY. It may not necessarily be applicable to this product.
 NCBI GI #    9951915
 NCBI GeneID    191
 NCBI Accession #    NP_000678.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000687.2 [Other Products]
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 UniProt Primary Accession #    P23526 [Other Products]
 UniProt Secondary Accession #    Q96A36; A8K307; B3KUN3; E1P5P2; F5H737 [Other Products]
 UniProt Related Accession #    P23526 [Other Products]
 Molecular Weight    63.6kD
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 NCBI Official Full Name    adenosylhomocysteinase isoform 1
 NCBI Official Synonym Full Names    adenosylhomocysteinase
 NCBI Official Symbol    AHCY [Similar Products]
 NCBI Official Synonym Symbols   
SAHH; adoHcyase
[Similar Products]
 NCBI Protein Information    adenosylhomocysteinase
 UniProt Protein Name    Adenosylhomocysteinase
 UniProt Synonym Protein Names   
S-adenosyl-L-homocysteine hydrolase
 Protein Family    Adenosylhomocysteinase
 UniProt Gene Name    AHCY [Similar Products]
 UniProt Synonym Gene Names    SAHH; AdoHcyase [Similar Products]
 UniProt Entry Name    SAHH_HUMAN
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 NCBI Summary for AHCY    S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
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 UniProt Comments for AHCY    SAHH: Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Defects in AHCY are the cause of hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD). A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy. Belongs to the adenosylhomocysteinase family.

Protein type: Hydrolase; EC 3.3.1.1; Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - cysteine and methionine

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: cytoplasm; cytosol; melanosome; neuron projection; nucleus

Molecular Function: adenosylhomocysteinase activity; adenyl nucleotide binding; identical protein binding; NAD binding; protein binding

Biological Process: chronic inflammatory response to antigenic stimulus; circadian sleep/wake cycle; methylation; one-carbon compound metabolic process; response to hypoxia; response to nutrient; S-adenosylhomocysteine catabolic process; S-adenosylmethionine cycle; selenium metabolic process; sulfur amino acid metabolic process; xenobiotic metabolic process

Disease: Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency
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Product References and Citations for AHCY recombinant protein

   Sequence of full length cDNA for human S-adenosylhomocysteine hydrolase.Coulter-Karis D.E., Hershfield M.S.Ann. Hum. Genet. 53:169-175(1989)
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 Research Articles on AHCY    1. S-adenosylhomocysteine hydrolase is regulated by lysine acetylation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AHCY recombinant proteinPathways associated with AHCY recombinant protein
 Reference Product  PubMed Publications
 MAT1A recombinant protein  >6 publications with AHCY and MAT1A
 BHMT recombinant protein  >6 publications with AHCY and BHMT
 CBS recombinant protein  >5 publications with AHCY and CBS
 MTRR recombinant protein  >4 publications with AHCY and MTRR
 MAT2A recombinant protein  >4 publications with AHCY and MAT2A
 MTR recombinant protein  >4 publications with AHCY and MTR
 DNMT1 recombinant protein  >1 publications with AHCY and DNMT1
 CTH recombinant protein  >1 publications with AHCY and CTH
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Metabolism Of Ingested SeMet, Sec, MeSec Into H2Se Pathway antibodies  Metabolism Of Ingested SeMet, Sec, MeSec Into H2Se Pathway Diagram
 Methionine Degradation Pathway antibodies  Methionine Degradation Pathway Diagram
 Methionine Degradation Pathway antibodies  Methionine Degradation Pathway Diagram
Diseases associated with AHCY recombinant proteinOrgans/Tissues associated with AHCY recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >5 publications with AHCY and Liver Diseases
 Necrosis Antibodies  >4 publications with AHCY and Necrosis
 Disease Models, Animal Antibodies  >4 publications with AHCY and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >3 publications with AHCY and Cardiovascular Diseases
 Fatty Liver Antibodies  >3 publications with AHCY and Fatty Liver
 Nervous System Diseases Antibodies  >3 publications with AHCY and Nervous System Diseases
 Hepatitis Antibodies  >3 publications with AHCY and Hepatitis
 Inflammation Antibodies  >2 publications with AHCY and Inflammation
 Amino Acid Metabolism, Inborn Errors Antibodies  >2 publications with AHCY and Amino Acid Metabolism, Inborn Errors
 Carcinoma, Hepatocellular Antibodies  >1 publications with AHCY and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with AHCY and Blood
 Liver Antibodies  >14 publications with AHCY and Liver
 Brain Antibodies  >4 publications with AHCY and Brain
 Embryonic Tissue Antibodies  >3 publications with AHCY and Embryonic Tissue
 Muscle Antibodies  >3 publications with AHCY and Muscle
 Ovary Antibodies  >2 publications with AHCY and Ovary
 Kidney Antibodies  >2 publications with AHCY and Kidney
 Heart Antibodies  >2 publications with AHCY and Heart
 Mammary Gland Antibodies  >1 publications with AHCY and Mammary Gland
 Intestine Antibodies  >1 publications with AHCY and Intestine
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