NP_000017.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,328 Da
NCBI Official Full Name
adenylosuccinate lyase isoform a
NCBI Official Synonym Full Names
adenylosuccinate lyase
NCBI Protein Information
adenylosuccinate lyase
UniProt Protein Name
Adenylosuccinate lyase
UniProt Synonym Protein Names
Adenylosuccinase
UniProt Synonym Gene Names
NCBI Summary for ADSL
The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
UniProt Comments for ADSL
Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
Research Articles on ADSL
Precautions
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Products associated with ADSL recombinant protein
Pathways associated with ADSL recombinant protein
Products by Pathway |
Pathway Diagram |
Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies |
Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram |
Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies |
Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram |
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies |
Alanine, Aspartate And Glutamate Metabolism Pathway Diagram |
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies |
Alanine, Aspartate And Glutamate Metabolism Pathway Diagram |
Inosine Monophosphate Biosynthesis, PRPP + Glutamine => IMP Pathway antibodies |
Inosine Monophosphate Biosynthesis, PRPP + Glutamine => IMP Pathway Diagram |
Inosine Monophosphate Biosynthesis, PRPP + Glutamine => IMP Pathway antibodies |
Inosine Monophosphate Biosynthesis, PRPP + Glutamine => IMP Pathway Diagram |
Metabolic Pathways antibodies |
Metabolic Pathways Diagram |
Metabolism Pathway antibodies |
Metabolism Pathway Diagram |
Metabolism Of Nucleotides Pathway antibodies |
Metabolism Of Nucleotides Pathway Diagram |
Nucleotide Metabolism Pathway antibodies |
Nucleotide Metabolism Pathway Diagram |
Diseases associated with ADSL recombinant protein
Organs/Tissues associated with ADSL recombinant protein
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