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mAcrp30 recombinant protein :: Adiponectin Trimeric Form Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142124 mAcrp30 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $6,135 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Adiponectin Trimeric Form (mAcrp30), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Adiponectin Trimeric Form

 Product Synonym Names    Acrp30 Mouse, Trimeric; Adiponectin Mouse Recombinant, Trimeric form; Acrp30; AdipoQ; GBP-28; APM-1; ACDC; mAcrp30 Tri
 Product Gene Name   

mAcrp30 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q60994
 Host    HEK293 (Human embryonic kidney cell line)
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 Purity/Purification    Acrp30 Mouse purity is greater than 95% as determined by SDS-PAGE.
 Form/Format    Mouse Acrp30 filtered (0.4 um) and lyophilized from 0.5 mg/ml in 0.05M phosphate buffer, 0.05M NaCl, pH 7.2.
Filtered white lyophilized (freeze-dried) powder.
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 Patent Rights    The sale and/or commercial use of Recombinant Adiponectin is prohibited in the United States of America (U.S.A).
 Solubility    Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
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 Preparation and Storage    Store lyophilized Acrp30 Mouse at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted Acrp30 Mouse can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
 Other Notes    Small volumes of mAcrp30 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for mAcrp30 recombinant protein

   Description: Trimeric form of Acrp30 Mouse was expressed in HEK293 cells.The cysteine 39 was replaced with alanine (C39A) 9. mAd-C39A can only form trimer, but not hexamer or HMW form.

Introduction: Adiponectin is a hormone exclusively expressed from adipose tissue. Many studies demonstrate that adiponectin has direct anti-diabetic, anti-atherogenic and anti-inflammatory functions. APM-1 can increase insulin sensitivity of skeletal muscle, attenuate hepatic lipogenesis and luconeogenesis, regulate NO production in endothelial cells, inhibit proliferation of smooth muscle cells and prevent lipid accumulation of macrophage cells.In the circulation, adiponectin is present as three different oligomeric complexes, including the high molecular weight (HMW), the middle molecular weight (MMW, also called hexamer) and low molecular weigh (MMW, also called trimer) forms 8. Different oligomeric complex of adiponectin activates different signaling pathways and exerts distinct functions.
 Product Categories/Family for mAcrp30 recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Adiponectin
NCBI/Uniprot data below describe general gene information for mAcrp30. It may not necessarily be applicable to this product.
 NCBI GI #    87252711
 NCBI GeneID    11450
 NCBI Accession #    NP_033735.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_009605.4 [Other Products]
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 UniProt Primary Accession #    Q60994 [Other Products]
 UniProt Secondary Accession #    Q62400; Q6GTX4; Q9DC68 [Other Products]
 UniProt Related Accession #    Q60994 [Other Products]
 Molecular Weight    26,809 Da
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 NCBI Official Full Name    adiponectin
 NCBI Official Synonym Full Names    adiponectin, C1Q and collagen domain containing
 NCBI Official Symbol    Adipoq [Similar Products]
 NCBI Official Synonym Symbols   
Ad; APN; Acdc; apM1; 30kDa; GBP28; adipo; Acrp30
[Similar Products]
 NCBI Protein Information    adiponectin; 30 kDa adipocyte complement-related protein; adipocyte complement related protein; adipocyte complement-related 30 kDa protein; adipocyte, C1Q and collagen domain containing; adipocyte, C1q and collagen domain-containing protein; adipocyte-specific protein AdipoQ
 UniProt Protein Name    Adiponectin
 UniProt Synonym Protein Names   
30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein; ACRP30; Adipocyte, C1q and collagen domain-containing protein; Adipocyte-specific protein AdipoQ
 UniProt Gene Name    Adipoq [Similar Products]
 UniProt Synonym Gene Names    Acdc; Acrp30; Apm1; ACRP30 [Similar Products]
 UniProt Entry Name    ADIPO_MOUSE
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 UniProt Comments for mAcrp30    adiponectin: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly may rely aditionally on lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9A via the C1q domain (heterotrimeric complex). Synthesized exclusively by adipocytes and secreted into plasma.

Protein type: Secreted; Secreted, signal peptide; Endoplasmic reticulum; Hormone

Cellular Component: extracellular space; protein complex; cell surface; collagen; endoplasmic reticulum; extracellular region

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; hormone activity; sialic acid binding; receptor binding

Biological Process: negative regulation of phagocytosis; negative regulation of MAP kinase activity; negative regulation of smooth muscle cell proliferation; negative regulation of hormone secretion; positive regulation of cellular protein metabolic process; membrane hyperpolarization; negative regulation of smooth muscle cell migration; glucose homeostasis; negative regulation of granulocyte differentiation; positive regulation of interleukin-8 production; positive regulation of glucose import; negative regulation of gluconeogenesis; response to glucose stimulus; adiponectin-mediated signaling pathway; negative regulation of protein amino acid autophosphorylation; negative regulation of blood pressure; negative regulation of cell migration; protein homooligomerization; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of signal transduction; negative regulation of heterotypic cell-cell adhesion; glucose metabolic process; negative regulation of tumor necrosis factor production; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of fat cell differentiation; negative regulation of synaptic transmission; membrane depolarization; positive regulation of peptidyl-tyrosine phosphorylation; fatty acid beta-oxidation; positive regulation of fatty acid metabolic process; cellular response to insulin stimulus; negative regulation of macrophage differentiation; negative regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of protein kinase activity; negative regulation of inflammatory response; brown fat cell differentiation; fatty acid oxidation; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; positive regulation of myeloid cell apoptosis; positive regulation of blood pressure
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 Research Articles on mAcrp30    1. documented that either adiponectin or the synthetic peptide with adiponectin properties, ADP355, suppressed p-FAK in synthetic matrices with stiffness measurements of 9 and 15 kPa
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with mAcrp30 recombinant proteinDiseases associated with mAcrp30 recombinant protein
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Leptin And Adiponectin Pathway antibodies  Leptin And Adiponectin Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 PPAR (Peroxisome Proliferator-activated Receptor) Signaling Pathway antibodies  PPAR (Peroxisome Proliferator-activated Receptor) Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >641 publications with mAcrp30 and Insulin Resistance
 Obesity Antibodies  >596 publications with mAcrp30 and Obesity
 Cardiovascular Diseases Antibodies  >424 publications with mAcrp30 and Cardiovascular Diseases
 Diabetes Mellitus Antibodies  >383 publications with mAcrp30 and Diabetes Mellitus
 Inflammation Antibodies  >268 publications with mAcrp30 and Inflammation
 Diabetes Mellitus, Type 2 Antibodies  >266 publications with mAcrp30 and Diabetes Mellitus, Type 2
 Necrosis Antibodies  >196 publications with mAcrp30 and Necrosis
 Heart Diseases Antibodies  >187 publications with mAcrp30 and Heart Diseases
 Atherosclerosis Antibodies  >166 publications with mAcrp30 and Atherosclerosis
 Metabolic Syndrome X Antibodies  >153 publications with mAcrp30 and Metabolic Syndrome X
Organs/Tissues associated with mAcrp30 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1162 publications with mAcrp30 and Blood
 Connective Tissue Antibodies  >299 publications with mAcrp30 and Connective Tissue
 Heart Antibodies  >162 publications with mAcrp30 and Heart
 Muscle Antibodies  >143 publications with mAcrp30 and Muscle
 Kidney Antibodies  >66 publications with mAcrp30 and Kidney
 Pancreas Antibodies  >24 publications with mAcrp30 and Pancreas
 Joint Antibodies  >18 publications with mAcrp30 and Joint
 Embryonic Tissue Antibodies  >16 publications with mAcrp30 and Embryonic Tissue
 Intestine Antibodies  >12 publications with mAcrp30 and Intestine
 Skin Antibodies  >11 publications with mAcrp30 and Skin
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