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Acrp30 recombinant protein :: Adiponectin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142309 Acrp30 recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $1,995 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Adiponectin (Acrp30), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Adiponectin, His tag

 Product Synonym Names    Acrp30 Human, His; Adiponectin Human Recombinant, His tag; Acrp30; AdipoQ; GBP-28; APM-1; ACDC; Acrp30 His
 Product Gene Name   

Acrp30 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHH HHHGSG HDQETTT QGPGVLLPLP KGACTGWMAG IPGHPGHNGA PGRDGRDGTP GEKGEKGDPG LIGPKGDIGE TGVPGAEGPR GFPGIQGRKG EPGEGAYVYR SAFSVGLETY VTIPNMPIRF TKIFYNQQNH YDGSTGKFHC NIPGLYYFAY HITVYMKDVK VSLFKKDKAM LFTYDQYQEN NVDQASGSVL LHLEVGDQVW LQVYGEGERN GLYADNDNDS TFTGFLLYHD TN
 OMIM    125853
 3D Structure    ModBase 3D Structure for Q15848
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 Host    E Coli
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 Purity/Purification    Acrp30 Human purity is greater than 95% as determined by SDS-PAGE.
 Form/Format    Acrp30 Human was filtered (0.4 um) and lyophilized from 0.5 mg/ml in 0.02M Tris buffer pH7.5, 0.15M NaCl.
Filtered White lyophilized (freeze-dried) powder.
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 Patent Rights    The sale and/or commercial use of Recombinant Adiponectin is prohibited in the United States of America (U.S.A).
 Solubility    It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture.
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 Preparation and Storage    Store lyophilized Acrp30 Human at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted Acrp30 Human can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
 Other Notes    Small volumes of Acrp30 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Acrp30 recombinant protein

   Description: The Acrp30 Human is created as a recombinant protein with N-terminal fusion of His Tag. The Adiponectin His-Tagged Fusion Protein, produced in E Coli, is 26.4 kDa protein containing 230 amino acid residues of the Acrp30 Human and 12 additional amino acid residues - HisTag (underlined).

Introduction: Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 amino acid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells (Adipokine). The protein belongs to the soluble defense collagen super family; it has a collagen-like domain structurally homologous with collagen VIII and X and complement factor C1q-like globular domain. APM-1 forms homotrimers, which are the building blocks for higher order complexes found circulating in serum.
 Product Categories/Family for Acrp30 recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Adiponectin
NCBI/Uniprot data below describe general gene information for Acrp30. It may not necessarily be applicable to this product.
 NCBI GI #    295317372
 NCBI GeneID    9370
 NCBI Accession #    NP_001171271.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001177800.1 [Other Products]
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 UniProt Primary Accession #    Q15848 [Other Products]
 UniProt Secondary Accession #    Q58EX9 [Other Products]
 UniProt Related Accession #    Q15848 [Other Products]
 Molecular Weight    26,414 Da
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 NCBI Official Full Name    adiponectin
 NCBI Official Synonym Full Names    adiponectin, C1Q and collagen domain containing
 NCBI Official Symbol    ADIPOQ [Similar Products]
 NCBI Official Synonym Symbols   
ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1
[Similar Products]
 NCBI Protein Information    adiponectin; 30 kDa adipocyte complement-related protein; adipocyte complement-related 30 kDa protein; adipose most abundant gene transcript 1 protein; adipose specific collagen-like factor; gelatin-binding protein 28
 UniProt Protein Name    Adiponectin
 UniProt Synonym Protein Names   
30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein; ACRP30; Adipocyte, C1q and collagen domain-containing protein; Adipose most abundant gene transcript 1 protein; apM-1; Gelatin-binding protein
 Protein Family    Adiponectin
 UniProt Gene Name    ADIPOQ [Similar Products]
 UniProt Synonym Gene Names    ACDC; ACRP30; APM1; GBP28; ACRP30; apM-1 [Similar Products]
 UniProt Entry Name    ADIPO_HUMAN
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 NCBI Summary for Acrp30    This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
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 UniProt Comments for Acrp30    adiponectin: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly may rely aditionally on lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9A via the C1q domain (heterotrimeric complex). Synthesized exclusively by adipocytes and secreted into plasma.

Protein type: Hormone; Secreted; Endoplasmic reticulum; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: extracellular space; collagen; cell surface; endoplasmic reticulum; extracellular region

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; hormone activity; cytokine activity; sialic acid binding; receptor binding

Biological Process: circadian rhythm; negative regulation of phagocytosis; negative regulation of MAP kinase activity; negative regulation of smooth muscle cell proliferation; negative regulation of hormone secretion; response to glucocorticoid stimulus; positive regulation of cellular protein metabolic process; membrane hyperpolarization; negative regulation of smooth muscle cell migration; glucose homeostasis; negative regulation of granulocyte differentiation; positive regulation of interleukin-8 production; positive regulation of glucose import; negative regulation of gluconeogenesis; response to glucose stimulus; adiponectin-mediated signaling pathway; negative regulation of protein amino acid autophosphorylation; negative regulation of blood pressure; negative regulation of cell migration; response to nutrient; protein homooligomerization; generation of precursor metabolites and energy; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of heterotypic cell-cell adhesion; positive regulation of signal transduction; glucose metabolic process; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of tumor necrosis factor production; negative regulation of fat cell differentiation; negative regulation of synaptic transmission; response to sucrose stimulus; membrane depolarization; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; positive regulation of fatty acid metabolic process; fatty acid beta-oxidation; negative regulation of macrophage differentiation; negative regulation of low-density lipoprotein receptor biosynthetic process; cellular response to insulin stimulus; negative regulation of inflammatory response; brown fat cell differentiation; response to hypoxia; fatty acid oxidation; positive regulation of protein amino acid phosphorylation; response to activity; negative regulation of transcription, DNA-dependent; positive regulation of myeloid cell apoptosis; positive regulation of blood pressure

Disease: Adiponectin, Serum Level Of, Quantitative Trait Locus 1
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 Research Articles on Acrp30    1. study found a significant association between ADIPOQ rs17366568 and obesity; ADIPOQ rs3774261 was not associated with obesity; neither ADIPOQ rs17366568 nor rs3774261 was associated with adiponectin levels
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Acrp30 recombinant proteinPathways associated with Acrp30 recombinant protein
 Reference Product  PubMed Publications
 PPARG recombinant protein  >130 publications with Acrp30 and PPARG
 ADIPOR1 recombinant protein  >117 publications with Acrp30 and ADIPOR1
 ADIPOR2 recombinant protein  >101 publications with Acrp30 and ADIPOR2
 LEP recombinant protein  >37 publications with Acrp30 and LEP
 FABP4 recombinant protein  >29 publications with Acrp30 and FABP4
 INS recombinant protein  >8 publications with Acrp30 and INS
 CEBPB recombinant protein  >3 publications with Acrp30 and CEBPB
 WNT10B recombinant protein  >1 publications with Acrp30 and WNT10B
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
Diseases associated with Acrp30 recombinant proteinOrgans/Tissues associated with Acrp30 recombinant protein
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >641 publications with Acrp30 and Insulin Resistance
 Obesity Antibodies  >596 publications with Acrp30 and Obesity
 Cardiovascular Diseases Antibodies  >424 publications with Acrp30 and Cardiovascular Diseases
 Diabetes Mellitus Antibodies  >383 publications with Acrp30 and Diabetes Mellitus
 Inflammation Antibodies  >268 publications with Acrp30 and Inflammation
 Diabetes Mellitus, Type 2 Antibodies  >266 publications with Acrp30 and Diabetes Mellitus, Type 2
 Necrosis Antibodies  >196 publications with Acrp30 and Necrosis
 Heart Diseases Antibodies  >187 publications with Acrp30 and Heart Diseases
 Atherosclerosis Antibodies  >166 publications with Acrp30 and Atherosclerosis
 Metabolic Syndrome X Antibodies  >153 publications with Acrp30 and Metabolic Syndrome X
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >461 publications with Acrp30 and Adipose Tissue
 Heart Antibodies  >162 publications with Acrp30 and Heart
 Kidney Antibodies  >66 publications with Acrp30 and Kidney
 Brain Antibodies  >63 publications with Acrp30 and Brain
 Intestine Antibodies  >12 publications with Acrp30 and Intestine
 Skin Antibodies  >11 publications with Acrp30 and Skin
 Nerve Antibodies  >10 publications with Acrp30 and Nerve
 Testis Antibodies  >3 publications with Acrp30 and Testis
 Mammary Gland Antibodies  >2 publications with Acrp30 and Mammary Gland
 Thymus Antibodies  >1 publications with Acrp30 and Thymus
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