NP_001278844.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,986 Da
NCBI Official Full Name
complement factor D isoform 2 preproprotein
NCBI Official Synonym Full Names
complement factor D (adipsin)
NCBI Official Synonym Symbols
NCBI Protein Information
complement factor D
UniProt Protein Name
Complement factor D
UniProt Synonym Protein Names
28 kDa adipocyte protein; Adipsin; C3 convertase activator; Properdin factor D
UniProt Synonym Gene Names
NCBI Summary for CFD
This gene encodes a serine protease that plays an important role in the alternative pathway of complement activation for pathogen recognition and elimination. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that in turn cleaves factor B in the complement pathway. This gene is expressed in adipocytes and the mature enzyme is secreted into the bloodstream. Mice lacking the encoded product cannot initiate alternative pathway of complement activation. [provided by RefSeq, Jul 2016]
UniProt Comments for CFD
CFD: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Defects in CFD are the cause of complement factor D deficiency (CFDD). CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. Belongs to the peptidase S1 family.
Protein type: EC 3.4.21.46; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10 C1|10 39.72 cM
Cellular Component: extracellular space
Molecular Function: endopeptidase activity
Biological Process: Notch signaling pathway
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Pathways associated with CFD recombinant protein
Diseases associated with CFD recombinant protein
Organs/Tissues associated with CFD recombinant protein
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