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ALPP recombinant protein :: Alkaline phosphatase, placental type (ALPP) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS951926 ALPP recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alkaline phosphatase, placental type (ALPP), Recombinant Protein

 Also Known As   

Recombinant Human Alkaline phosphatase, placental type (ALPP)

 Product Synonym Names    Recombinant Alkaline phosphatase, placental type (ALPP); Alkaline phosphatase, placental type EC= 3.1.3.1; Alkaline phosphatase Regan isozyme Placental alkaline phosphatase 1; PLAP-1
 Product Gene Name   

ALPP recombinant protein

[Similar Products]
 Product Synonym Gene Name    ALPP; PLAP [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    23-506
 Sequence    IIPVEEENPD FWNREAAEAL GAAKKLQPAQ TAAKNLIIFL GDGMGVSTVT AARILKGQKK DKLGPEIPLA MDRFPYVALS KTYNVDKHVP DSGATATAYL CGVKGNFQTI GLSAAARFNQ CNTTRGNEVI SVMNRAKKAG KSVGVVTTTR VQHASPAGTY AHTVNRNWYS DADVPASARQ EGCQDIATQL ISNMDIDVIL GGGRKYMFRM GTPDPEYPDD YSQGGTRLDG KNLVQEWLAK RQGARYVWNR TELMQASLDP SVTHLMGLFE PGDMKYEIHR DSTLDPSLME MTEAALRLLS RNPRGFFLFV EGGRIDHGHH ESRAYRALTE TIMFDDAIER AGQLTSEEDT LSLVTADHSH VFSFGGYPLR GSSIFGLAPG KARDRKAYTV LLYGNGPGYV LKDGARPDVT ESESGSPEYR QQSAVPLDEE THAGEDVAVF ARGPQAHLVH GVQEQTFIAH VMAFAACLEP YTACDLAPPA GTTD
 Chromosome Location    Chromosome: 2; NC_000002.11 (233243348..233247599). Location: 2q37
 OMIM    171800
 3D Structure    ModBase 3D Structure for P05187
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ALPP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ALPP. It may not necessarily be applicable to this product.
 NCBI GI #    94721246
 NCBI GeneID    250
 NCBI Accession #    NP_001623.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001632.3 [Other Products]
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 UniProt Primary Accession #    P05187 [Other Products]
 UniProt Secondary Accession #    P05188; P06861; Q53S78; Q96DB7 [Other Products]
 UniProt Related Accession #    P05187 [Other Products]
 Molecular Weight    57,954 Da [Similar Products]
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 NCBI Official Full Name    alkaline phosphatase, placental type preproprotein
 NCBI Official Synonym Full Names    alkaline phosphatase, placental
 NCBI Official Symbol    ALPP [Similar Products]
 NCBI Official Synonym Symbols   
ALP; PALP; PLAP; PLAP-1
[Similar Products]
 NCBI Protein Information    alkaline phosphatase, placental type; Regan isozyme; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme
 UniProt Protein Name    Alkaline phosphatase, placental type
 UniProt Synonym Protein Names   
Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1
 Protein Family    Alkaline phosphatase
 UniProt Gene Name    ALPP [Similar Products]
 UniProt Synonym Gene Names    PLAP; PLAP-1 [Similar Products]
 UniProt Entry Name    PPB1_HUMAN
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 NCBI Summary for ALPP    There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ALPP    ALPP: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]

Protein type: Phosphatase (non-protein); EC 3.1.3.1; Motility/polarity/chemotaxis; Membrane protein, GPI anchor; Cofactor and Vitamin Metabolism - folate biosynthesis; Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: cell surface; plasma membrane; integral to membrane

Molecular Function: zinc ion binding; alkaline phosphatase activity; magnesium ion binding

Biological Process: dephosphorylation
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 Research Articles on ALPP    1. Calculation of the electrostatic potentials within the active site of human placental alkaline phosphatase also suggests that the local positive electrostatic environment may account for its capability to distinguish various substrates
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ALPP recombinant proteinDiseases associated with ALPP recombinant protein
 Products by Pathway  Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >140 publications with ALPP and Neoplasms
 Adenocarcinoma Antibodies  >26 publications with ALPP and Adenocarcinoma
 Pregnancy Complications Antibodies  >21 publications with ALPP and Pregnancy Complications
 Nervous System Diseases Antibodies  >16 publications with ALPP and Nervous System Diseases
 Lung Neoplasms Antibodies  >10 publications with ALPP and Lung Neoplasms
 Lung Diseases Antibodies  >10 publications with ALPP and Lung Diseases
 Disease Models, Animal Antibodies  >10 publications with ALPP and Disease Models, Animal
 Breast Neoplasms Antibodies  >6 publications with ALPP and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >5 publications with ALPP and Prostatic Neoplasms
 Liver Diseases Antibodies  >4 publications with ALPP and Liver Diseases
Organs/Tissues associated with ALPP recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >85 publications with ALPP and Placenta
 Intestine Antibodies  >10 publications with ALPP and Intestine
 Uterus Antibodies  >6 publications with ALPP and Uterus
 Heart Antibodies  >6 publications with ALPP and Heart
 Amniotic Fluid Antibodies  >1 publications with ALPP and Amniotic Fluid
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